Is there a link between TNF gene expression and cognitive deficits in depression?

Bobińska, Kinga; Gałecka, Elżbieta; Szemraj, Janusz; Gałecki, Piotr; Talarowska, Monika

doi:10.18388/abp.2016_1276

Cited by 35 publications

(35 citation statements)

References 58 publications

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“…The finding that there were lower levels of TNFR2 mRNA in the cortex of patients with major depression and bipolar disorder compared with those with schizophrenia and controls uniquely adds to a growing body of research implicating TNFR2 in mood disorders . These data from the CNS contrast to those showing higher levels of TNFR2 mRNA in white blood cells, and higher TNFR2 mRNA and soluble protein in blood from individuals with major depression . An association between elevated TNFR2 expression and cognitive deficits does not fit with the hypothesis of a protective role for TNFR2 in mood disorders.…”

Section: Tnfr2: Structure Function and Possible Role In The Pathophymentioning

confidence: 80%

“…18 These data from the CNS contrast to those showing higher levels of TNFR2 mRNA in white blood cells, 75 and higher TNFR2 mRNA and soluble protein in blood from individuals with major depression. 76 An association between elevated TNFR2 expression and cognitive deficits does not fit with the hypothesis of a protective role for TNFR2 in mood disorders. However, individuals with higher levels of TNFR2 expression and protein show similar elevations in TNFR1 mRNA and protein.…”

Section: Tnfr2 Abnormalities In Mood Disordersmentioning

confidence: 96%

“…An association between elevated TNFR2 expression and cognitive deficits does not fit with the hypothesis of a protective role for TNFR2 in mood disorders. However, individuals with higher levels of TNFR2 expression and protein show similar elevations in TNFR1 mRNA and protein . Therefore, changes in levels of TNFR1 could be associated with the poorer cognitive functioning in individuals with major depression.…”

Section: Tnfr2: Structure Function and Possible Role In The Pathophymentioning

confidence: 99%

“…Therefore, changes in levels of TNFR1 could be associated with the poorer cognitive functioning in individuals with major depression. It is, therefore, of interest that individuals with elevated levels of soluble TNFR2 protein and mRNA in blood showed cognitive deficits that included poorer working memory and executive function . Another study reported higher levels of soluble TNFR2 protein in patients with bipolar disorder that did not change with improvements in the severity of depressive symptoms .…”

Section: Tnfr2: Structure Function and Possible Role In The Pathophymentioning

confidence: 99%

“…However, individuals with higher levels of TNFR2 expression and protein show similar elevations in TNFR1 mRNA and protein. 75,76 Therefore, changes in levels of TNFR1 could be associated with the poorer cognitive functioning in individuals with major depression. It is, therefore, of interest that individuals with elevated levels of soluble TNFR2 protein and mRNA in blood showed cognitive deficits that included poorer working memory and executive function.…”

Section: Tnfr2 Abnormalities In Mood Disordersmentioning

confidence: 99%

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Tumor necrosis factor receptor 2: A potential target for antidepressant drug development

Seymour

Gibbons

Dean

2019

Clinical & Exp Neuroim

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A large body of work implicates cytokines and their related pathways in the pathophysiologies of mood disorders. Much of the data on the role of cytokines in major depression and bipolar disorder suggest that pathways regulated by tumor necrosis factor (TNF)‐α make a significant contribution to their pathophysiologies. In the present review, we contrast the well‐established role of TNF‐related pathways acting to mediate classic pro‐inflammatory cytokine activity with growing evidence that such pathways have more diverse functions in the human central nervous system. Here, it will be argued that changes in levels of the TNF receptor type 2 in mood disorders would be consistent with a neuroprotective role for the receptor against the pathophysiologies of mood disorders. This hypothesis is of significance when considering how interventions that act to modulate TNF‐regulated pathways can be used to treat the symptoms of mood disorders.

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Section: Tnfr2: Structure Function and Possible Role In The Pathophymentioning

confidence: 80%

Section: Tnfr2 Abnormalities In Mood Disordersmentioning

confidence: 96%

Section: Tnfr2: Structure Function and Possible Role In The Pathophymentioning

confidence: 99%

Section: Tnfr2: Structure Function and Possible Role In The Pathophymentioning

confidence: 99%

Section: Tnfr2 Abnormalities In Mood Disordersmentioning

confidence: 99%

See 3 more Smart Citations

Tumor necrosis factor receptor 2: A potential target for antidepressant drug development

Seymour

Gibbons

Dean

2019

Clinical & Exp Neuroim

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Dietary composition influences sperm quality and testis damage via endoplasmic reticulum stress in lambs

Imik,

Eren,

Can

et al. 2024

Veterinary Medicine & Sci

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BackgroundThe metabolic impacts of including soya meal, wheat gluten and corn gluten in the diet of male lambs could influence their reproductive performance.ObjectivesAn experiment was carried out to assess the effects of corn gluten, wheat gluten and soya meal on the reproductive system of male lambs.MethodsTwenty‐four male Morkaraman lambs, aged 9 months, were utilized in this study and were fed experimental diets for 56 days. The lambs were divided into a control group (soybean meal + safflower meal), a corn group (corn gluten) and a wheat group (wheat gluten).ResultsThe serum follicle‐stimulating hormone level of the control group was significantly higher and tumour necrosis factor‐alpha (TNF‐α) level was lower than the wheat and corn gluten groups (p < 0.05). The lowest malondialdehyde level in testicular tissue was observed in the control group, whereas the highest was in the wheat gluten group (p < 0.05). The glutathione level in the control group was significantly higher than in the other groups (p < 0.05). The corn gluten group showed the highest CHOP and IRE1 levels; the lowest Bcl‐2 levels and the highest IL‐1B and P2 × 7R levels were found in the wheat group; and the lowest TNF‐α levels were in the control group (p < 0.05). Additionally, the study revealed that diet had a significant impact on spermatological parameters of the testis such as diameter, volume and weight (p < 0.05).ConclusionsThese results concluded that the inclusion of different protein sources in the diet of reproductive male lambs affects the metabolism of testicular tissue.

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Patients with obstructive sleep apnea have suppressed levels of soluble cytokine receptors involved in neurodegenerative disease, but normal levels with airways therapy

et al. 2020

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Purpose Obstructive sleep apnea (OSA) results in systemic intermittent hypoxia. By one model, hypoxic stress signaling in OSA patients alters the levels of inflammatory soluble cytokines TNF and IL6, damages the blood brain barrier, and activates microglial targeting of neuronal cell death to increase the risk of neurodegenerative disorders and other diseases. However, it is not yet clear if OSA significantly alters the levels of the soluble isoforms of TNF receptors TNFR1 and TNFR2 and IL6 receptor (IL6R) and co-receptor gp130, which have the potential to modulate TNF and IL6 signaling. Methods Picogram per milliliter levels of the soluble isoforms of these four cytokine receptors were estimated in OSA patients, in OSA patients receiving airways therapy, and in healthy control subjects. Triplicate samples were examined using Bio-Plex fluorescent bead microfluidic technology. The statistical significance of cytokine data was estimated using the nonparametric Wilcoxon rank-sum test. The clustering of these high-dimensional data was visualized using t-distributed stochastic neighbor embedding (t-SNE). Results OSA patients had significant twofold to sevenfold reductions in the soluble serum isoforms of all four cytokine receptors, gp130, IL6R, TNFR1, and TNFR2, as compared with control individuals (p = 1.8 × 10−13 to 4 × 10−8). Relative to untreated OSA patients, airways therapy of OSA patients had significantly higher levels of gp130 (p = 2.8 × 10−13), IL6R (p = 1.1 × 10−9), TNFR1 (p = 2.5 × 10−10), and TNFR2 (p = 5.7 × 10−9), levels indistinguishable from controls (p = 0.29 to 0.95). The data for most airway-treated patients clustered with healthy controls, but the data for a few airway-treated patients clustered with apneic patients. Conclusions Patients with OSA have aberrantly low levels of four soluble cytokine receptors associated with neurodegenerative disease, gp130, IL6R, TNFR1, and TNFR2. Most OSA patients receiving airways therapy have receptor levels indistinguishable from healthy controls, suggesting a chronic intermittent hypoxia may be one of the factors contributing to low receptor levels in untreated OSA patients.

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Is there a link between TNF gene expression and cognitive deficits in depression?

Cited by 35 publications

References 58 publications

Tumor necrosis factor receptor 2: A potential target for antidepressant drug development

Tumor necrosis factor receptor 2: A potential target for antidepressant drug development

Dietary composition influences sperm quality and testis damage via endoplasmic reticulum stress in lambs

Patients with obstructive sleep apnea have suppressed levels of soluble cytokine receptors involved in neurodegenerative disease, but normal levels with airways therapy

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