Is there a link between Takotsubo syndrome and some cases of nonischemic cardiomyopathy? A proposal of an animal model

Madias, John E.

doi:10.1016/j.ijcard.2013.12.080

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…Additionally, there have been numerous reports linking this entity to certain medications and toxins such as albuterol, 69 high-dose intravenous cytarabin, 70 5-fluorouracil, 71 entacapone, 72 and allopurinol 73 as well as the inhalation of hypochlorite gel exhalations. 74 Furthermore, a case has been reported on a possible link to cocaine abuse.…”

Section: Sympathoexcitation-induced Takotsubo Cardiomyopathymentioning

confidence: 99%

Reversible Cardiomyopathies

Patel

Madanieh

Kosmas

et al. 2015

Clin Med Insights Cardiol

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Cardiomyopathies (CMs) have many etiological factors that can result in severe structural and functional dysregulation. Fortunately, there are several potentially reversible CMs that are known to improve when the root etiological factor is addressed. In this article, we discuss several of these reversible CMs, including tachycardia-induced, peripartum, inflammatory, hyperthyroidism, Takotsubo, and chronic illness–induced CMs. Our discussion also includes a review on their respective pathophysiology, as well as possible management solutions.

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Section: Sympathoexcitation-induced Takotsubo Cardiomyopathymentioning

confidence: 99%

Reversible Cardiomyopathies

Patel

Madanieh

Kosmas

et al. 2015

Clin Med Insights Cardiol

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“…Although wall motion abnormality is, in general, transient in Takotsubo cardiomyopathy [ 10 ], several previous studies suggested that Takotsubo cardiomyopathy might be emerging as a chronic form [ 11 ], causing congestive heart failure and acute coronary syndrome-like symptoms. It is increasingly recognized that Takotsubo cardiomyopathy may not always be benign [ 12 ], and may cause left ventricular fibrosis [ 13 ] leading to appearance as a non-ischemic cardiomyopathy [ 14 ]. In addition, presence of Takotsubo cardiomyopathy may not be able to be recognized or diagnosed when it is not associated with anginal chest pain [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Basal wall hypercontraction of Takotsubo cardiomyopathy in a patient who had been diagnosed with dilated cardiomyopathy: a case report

Ichihara

Fujita

Kanzaki

et al. 2017

BMC Cardiovasc Disord

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BackgroundTakotsubo cardiomyopathy is characterized by the basal hypercontractility and apical ballooning of the left ventriculum and T-wave inversion in the electrocardiogram. It has been suggested that Takotsubo cardiomyopathy might underlie the pathogenesis of persistent cardiac dysfunction; however, few reports are present demonstrating the advent of Takotsubo cardiomyopathy in patients with idiopathic cardiomyopathy.Case presentationA 64-year-old women was admitted due to dyspnea on effort and lower extremity edema. She had been diagnosed with idiopathic dilated cardiomyopathy 2.5 years before owing to the reduced left ventricular ejection fraction (24%), normal coronary artery, and interstitial fibrosis of the myocardial samples. On admission, her electrocardiogram showed giant negative T wave in II, III, aVF, and precordial leads. Echocardiography showed dyskinesis of the left ventricular apex and hypercontraction of the basal wall, which had not been observed in the previous examinations. Coronary angiography showed normal coronary arteries, and apical ballooning and basal hypercontractility was confirmed by left ventriculography. On day 15 of admission, contraction of apical wall was recovered, and basal hypercontraction was disappeared.ConclusionThe present case is the first report demonstrating appearance the transient basal wall hypercontraction along with the advent of Takotsubo cardiomyopathy in a patient diagnosed with dilated cardiomyopathy. Whether such findings are indicative of fair prognosis and have the utility of understanding the pathogenesis of dilated cardiomyopathy needs further investigation.

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“…1 Also, the above have been entertained in the context of speculations that TTS may occasionally be chronic, in the sense of recurrent attacks, some possibly mild and atypical, 2,3 and that some forms of unexplained cases of non-ischaemic cardiomyopathy may be due to recurrent TTS. 4 The above string of thoughts was rekindled by the report of Voskoboinik et al, 5 published online ahead of print on 1 March 2016 in the Journal's Accepted Articles website and in print in the current issue, about their consecutive series of patients with methamphetamineassociated cardiomyopathy (MAC) and what is the association or differences among MAC, TTS and chronic, possibly irreversible cardiomyopathy in current or prior habitually methamphetamine abusers. The authors' 20 patients (6 female), with a mean age 35 years, with MAC were very sick (14 required inotropes and 5 mechanical support), with a mean left ventricular ejection fraction (LVEF) of~20%, a global systolic dysfunction (N = 14) and reverse TTS pattern (N = 6) predominantly in women, with a short history of methamphetamine abuse.…”

Section: Methamphetamine-triggered Takotsubo Syndrome and Methamphetamentioning

confidence: 99%

“…A tricuspid regurgitant jet may be absent in 20-39% of patients undergoing echocardiography. 4 The method of Abbas, while showing some promise for identification of subjects with elevated PVR, has a modest correlation with PVR and requires the use of different regression equations, depending on the individual to which it is applied. 3 We emphasise that the study by Quinlivan et al relates to annual screening for pulmonary arterial hypertension (PAH) in asymptomatic individuals with systemic sclerosis (scleroderma).…”

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confidence: 99%