Is there a limit for the number of in vitro fertilization cycles for an individual patient?

Homburg, Roy; Meltcer, Simion; Rabinson, Jacob; Scharf, Shimon; Anteby, Eyal Y.; Orvieto, Raoul

doi:10.1016/j.fertnstert.2008.03.010

Cited by 19 publications

(15 citation statements)

References 4 publications

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“…In accordance with the aforementioned studies, we also observed a significant decrease in pregnancy rate beyond the third IVF cycle attempt, with no significant decrease between the fourth and the 20th attempt (6).…”

supporting

confidence: 92%

“…It is of note that most of the studies dealing with recurrent implantation failure included IVF cycles using only the GnRH agonist (4, 5, 7) or all the accepted or standard IVF protocols, which include the use of GnRH agonists and antagonists (6,8). Moreover, while studying the effect of the GnRH analogues used during COH in patients with recurrent implantation failure, Takahashi et al (9) found that patients undergoing COH using the GnRH antagonist had improved pregnancy outcome, compared with those using the GnRH agonist, most likely because of improvement of the quality of the blastocysts generated.…”

mentioning

confidence: 99%

“…On the other hand, studies in patients undergoing ''standard'' or ''accepted'' IVF protocols, which probably used the GnRH agonists and antagonists, found either a decline between cycles 1 and 2 but a plateau in cycles 3 to 5 (8) or a significant decrease in pregnancy rate beyond the third IVF cycle attempt with no significant decrease between the fourth and the 20th attempt (6).…”

mentioning

confidence: 99%

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Repeated in vitro fertilization cycle attempts in patients undergoing controlled ovarian hyperstimulation with use of gonadotropin-releasing hormone antagonists

Rabinson

Ashkenazi

Homburg

et al. 2009

Fertility and Sterility

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supporting

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Repeated in vitro fertilization cycle attempts in patients undergoing controlled ovarian hyperstimulation with use of gonadotropin-releasing hormone antagonists

Rabinson

Ashkenazi

Homburg

et al. 2009

Fertility and Sterility

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“…Recently, in an attempt to examine whether and when conception may be achieved in multiple repeated IVF cycles, we conducted a survey of the outcome of IVF in 2760 consecutive cycles in our unit. In accordance with the aforementioned studies, we also observed a significant decreased in pregnancy rate beyond the 3 rd IVF cycle attempt, with no significant decrease between the 4 th to the 20 th attempt [5]. …”

Section: Introductionsupporting

confidence: 89%

Should zygote intrafallopian transfer be offered to all patients with unexplained repeated in-vitro fertilization cycle failures?

et al. 2014

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BackgroundOne of the suggest strategy for patients with repeated implantation failure (RIF) is zygote intrafallopian transfer (ZIFT). However, no data exist regarding to the issue of when and under which circumstances should ZIFT be offered to patients with RIF? We therefore aimed to examine whether repeated implantation failure (RIF) patients characteristics or their previous controlled ovarian hyperstimulation (COH) variables may differentiate between those who will conceive following a ZIFT cycle and those who will not.MethodsForty seven consecutive women admitted to our IVF unit during a 7 year period, who underwent ZIFT for RIF, were included. Ovarian stimulation characteristics, number of oocytes retrieved and number and quality of zygotes/embryos transferred were assessed and compared between the ZIFT cycle and the previous IVF/ICSI cycle and between those who conceived following the ZIFT cycle and those who did not.ResultsTwelve clinical pregnancies (clinical pregnancy rate- 25.5%) were recorded following the ZIFT cycle. Those who benefit from ZIFT were young patients (≤31 yrs), who underwent ≤6 cycle attempts, yielding over eight 2PN embryos with low (≤0.4) ratio of number of top-quality embryos to total 2PN embryos. Moreover, in those destined for a ZIFT cycle, only those with >7 2PN embryo should undergo a transfer of at least five 2PN embryos.ConclusionsFurther large prospective studies are needed to identify the specific characteristics of RIF women who may benefit from ZIFT.

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“…We excluded cases exceeding four cIVF/ICSI cycles based on the tendency of the data to statistically significantly decrease the pregnancy rate after the third cycle attempt [12][13][14], and the cycles of GnRH agonist, buserelin acetate nasal spray used, including short or long protocols, as controlled ovarian hyper-stimulation. Sixty-one cases corresponding to 97 cycles had a major indication for ART with endometriosis.…”

Section: Patient Selectionmentioning

confidence: 99%

The impact of endometriosis, endometrioma and ovarian cystectomy on assisted reproductive technology

Kuroda

Kitade

Kikuchi

et al. 2009

Reprod Medicine & Biology

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Purpose To assess outcomes in assisted reproductive technology (ART) in infertile women with endometriosis with respect to their concomitant endometrioma status and surgical history in our department. Methods This is a retrospective case control study which analyzes informational data obtained at a university hospital. The study drew from a patient pool of 332 cases (877 cIVF/ICSI cycles) that took place in our department from 2006 to 2008. Sixty-one cases (97 cycles) had major indications for cIVF/ICSI with endometriosis. We classified groups from these 61 cases as follows: an unoperated endometrioma group (A) with 31 cycles, a postoperative endometrioma group (B) with 51 cycles, and a no endometrioma group (C) with 15 cycles. We analyzed and compared these three groups and also included a nonendometriosis tubal infertility group (D) with 27 cycles. Results In the control group (D), serum FSH levels and the cancellation rates were significantly lower than those of other groups, and the number of developing follicles was higher. E2 levels before oocyte aspiration in the postoperative endometrioma group (B) was lower. Implantation, pregnancy, delivery and miscarriage rates were not significantly different among the four groups. Conclusion The results suggest that endometriosis causes a decrease in endocrinologic ovarian function whether or not an endometrioma is also present. As for E2 level before oocyte aspiration, our results suggest that ovarian reserves might be reduced by endometrioma excision, but this is difficult to evaluate. In the endometriosis groups, cancellation rates were significantly higher, although when embryos were transferred the pregnancy rates were not significantly different when compared with the non-endometriosis group. As for infertile women with endometriomas, our results suggest that preexisting ovarian reserve is reduced by the presence of endometriosis, and ovarian reserve might also be reduced by excision of endometriomas.

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Is there a limit for the number of in vitro fertilization cycles for an individual patient?

Cited by 19 publications

References 4 publications

Repeated in vitro fertilization cycle attempts in patients undergoing controlled ovarian hyperstimulation with use of gonadotropin-releasing hormone antagonists

Repeated in vitro fertilization cycle attempts in patients undergoing controlled ovarian hyperstimulation with use of gonadotropin-releasing hormone antagonists

Should zygote intrafallopian transfer be offered to all patients with unexplained repeated in-vitro fertilization cycle failures?

The impact of endometriosis, endometrioma and ovarian cystectomy on assisted reproductive technology

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