Is there a late-latency mismatch negativity (MMN) component?

Korpilahti, Pirjo; Lang, Heikki; Aaltonen, Olli

doi:10.1016/0013-4694(95)90016-g

Cited by 52 publications

(52 citation statements)

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“…In the developmental literature there are more frequent references to this component, though the authors label it differently. Kraus et al (1993) called it NM4, others as late MMN (Korpilahti, Lang, & Aaltonen, 1995), and Ceponiene, Cheour, and Näätänen (1998) named this component as LDN (late difference negativity). The later authors proposed that this difference detection in children shown by the LDN could be related to a further processing of the detected change.…”

Section: Discussionmentioning

confidence: 99%

Effect of maturation on suprasegmental speech processing in full- and preterm infants: A mismatch negativity study

Ragó

Honbolygó

Róna

et al. 2014

Research in Developmental Disabilities

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Infants born prematurely are at higher risk for later linguistic deficits present in delayed or atypical processing of phonetic and prosodic information. In order to be able to specify the nature of this atypical development, it is important to investigate the role of early experience in language perception. According to the concept of Gonzalez-Gomez and Nazzi (2012) there is a special intrauterine sensitivity to the prosodic features of languages that should have a special role in language acquisition. Therefore, we may also assume that pre-and full-term infants having months difference in intrauterine experience show different maturation patterns of processing prosodic and phonetic information present at word level. The aim of our study was to investigate the effect of these differences on word stress pattern vs. phoneme information processing. Two age groups of infants (6 and 10 month-olds) were included in our study. 21 of 46 of the total of infants investigated were prematurely born with low birth weight. We used the mismatch negativity (MMN) event related brain potential (ERP) component, a widely used electrophysiological correlate of acoustic change detection, for testing the assumed developmental changes of phoneme and word stress discrimination. In a passive oddball paradigm we used a word as standard, a pseudoword as phoneme deviant, and an illegally uttered word as stress deviant. Our results showed no differences in MMN responses in the phoneme deviant condition between the groups, meaning a relatively intact maturation of phoneme processing of preterm infants as compared to their contemporaries. However, the mismatch responses measured in the stress condition revealed significant betweengroup differences. These results strengthen the view that the total length of intrauterine experience influences the time of emergence of prosodic processing.

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Section: Discussionmentioning

confidence: 99%

Effect of maturation on suprasegmental speech processing in full- and preterm infants: A mismatch negativity study

Ragó

Honbolygó

Róna

et al. 2014

Research in Developmental Disabilities

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“…Maturation of LDN LDN has mainly been reported in children [Korpilahti, 1996;Korpilahti et al, 1995;Ceponiene et al, 1998;Cheour et al, submitted], although some studies have also obtained an LDN-like component in adults [Aaltonen, 1997;Alho et al, 1992;Trejo et al, 1995]. In contrast to MMN that matures surprisingly early, LDN does not seem to be as stable a response.…”

Section: Maturation Of Mmnmentioning

confidence: 99%

“…This negativity was first reported in children by Korpilahti et al [1995], who called it the late MMN. This negativity followed MMN and peaked at about 400-430 ms in response to changes in speech stimuli and tones in 5-to 10-year-old children and in young adults.…”

Section: Late Discriminative Negativity (Ldn)mentioning

confidence: 99%

Mismatch Negativity and Late Discriminative Negativity in Investigating Speech Perception and Learning in Children and Infants

Cheour¹,

Korpilahti²,

Martynova³

et al. 2001

Audiol Neurotol

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127

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For decades, behavioral methods, such as the head-turning or sucking paradigms, have been the primary tools to investigate speech perception and learning of a language in infancy. Recently, however, new methods provided by event-related potentials have emerged. These are called mismatch negativity (MMN) and late discriminative negativity (LDN). MMN, the brain’s automatic change-detection response in audition, has been intensively used in adults in both basic and clinical studies for longer than 20 years. LDN, on the other hand, was only recently discovered. There seem to be many differences between these two responses. MMN is developmentally quite stable and can be obtained even from preterm infants. LDN, however, can be obtained most reliably from young children, and its amplitude decreases as a function of age. New data suggest that both of these responses have a special role in language processing, although both of them can also be elicited by nonspeech stimuli.

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“…8 This late MMN component was suggested as a correlate for reduced auditory memory span 25 and a more specific correlate for linguistic processing. 21 Speech processing depends on the rapid integration of a complex set of acoustic features such as amplitude, frequency, duration, and rapid changes of speech signals. A speech-processing deficit has been found in a large subgroup of dyslexic individuals.…”

Section: Introductionmentioning

confidence: 99%

“…17,18 This fronto-centrally predominant scalp distribution of the MMN is mainly explained by the sum of generator activity in supratemporal cortices of both hemispheres. 19,20 Experiments using complex stimuli such as speech sounds, as opposed to simpler sounds such as sinus tones, detect a later MMN component, with a latency from 300 to 600 ms [8][9][10][21][22][23][24][25] and a left lateralized topography of the speech MMN in young children, adolescents, and adults. 4,8,11,24 In children at risk for dyslexia, a bilateral topography of the late speech MMN was found suggesting lateralization differences of this component in dyslexic children 24 and a predictor for word reading in fifth grade children.…”

Section: Introductionmentioning

confidence: 99%

First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children

et al. 2009

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Dyslexia is one of the most common learning disorders affecting about 5% of all school-aged children. It has been shown that event-related potential measurements reveal differences between dyslexic children and age-matched controls. This holds particularly true for mismatch negativity (MMN), which reflects automatic speech deviance processing and is altered in dyslexic children. We performed a whole-genome association analysis in 200 dyslexic children, focusing on MMN measurements. We identified rs4234898, a marker located on chromosome 4q32.1, to be significantly associated with the late MMN component. This association could be replicated in an independent second sample of 186 dyslexic children, reaching genome-wide significance in the combined sample (P = 5.14eÀ08). We also found an association between the late MMN component and a two-marker haplotype of rs4234898 and rs11100040, one of its neighboring single nucleotide polymorphisms (SNPs). In the combined sample, this marker combination withstands correction for multiple testing (P = 6.71eÀ08). Both SNPs lie in a region devoid of any protein-coding genes; however, they both show significant association with mRNA-expression levels of SLC2A3 on chromosome 12, the predominant facilitative glucose transporter in neurons. Our results suggest a possible transregulation effect on SLC2A3, which might lead to glucose deficits in dyslexic children and could explain their attenuated MMN in passive listening tasks.

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Is there a late-latency mismatch negativity (MMN) component?

Cited by 52 publications

References 0 publications

Effect of maturation on suprasegmental speech processing in full- and preterm infants: A mismatch negativity study

Effect of maturation on suprasegmental speech processing in full- and preterm infants: A mismatch negativity study

Mismatch Negativity and Late Discriminative Negativity in Investigating Speech Perception and Learning in Children and Infants

First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children

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