Is there a “Genetic model” in the genesis of malignant pleural mesothelioma?

Mesothelioma in blood related subjects: Report of 11 clusters among 1954 Italy cases and review of the literature

“…shipyard work, asbestos-cement production/processing, and insulation. It is notable that six clusters were associated with exposure because of asbestos-cement factory pollution, including previous [Precerutti et al, 1990;Dawson et al, 1992;Schneider et al, 1995;Musti et al, 2002] and new clusters (Table I, Apulia Registry, cluster no. II [Bilancia et al, 2003]; Brescia, cluster no.…”

“…In men, the mean age at diagnosis (58.8 years) was consistent with occupational exposure and adult age at first exposure; in women, the Hammar et al, 1989;Bianchi et al, 1993;Bisconti et al, 2000;Serio et al, 2004;Bianchi et al, 2004. 11 12/12 Asbestos cement production or processing 3 4 4 5 Anderson et al, 1976;Vianna and Polan, 1978;Otte et al, 1990;Precerutti et al, 1990;Dawson et al, 1992;Schneider et al,1995;Musti et al, 2002. 9 16/4 Insulation work 7 ö 2 8 Smith et al,1968;Li et al,1978;Martensson et al, 1984;Lynch et al, 1985;Hammar et al, 1989;Orn et al, 1991;Dawson et al,1992 In additional four clusters, there was evidence of environmental exposure to erionite [Baris et al, 1979] or to asbestos at school [Picklesimer et al, 2005], or any evidence of exposure [Hirsch et al, 1982;Munoz et al, 1988].…”

“…9 16/4 Insulation work 7 ö 2 8 Smith et al,1968;Li et al,1978;Martensson et al, 1984;Lynch et al, 1985;Hammar et al, 1989;Orn et al, 1991;Dawson et al,1992 In additional four clusters, there was evidence of environmental exposure to erionite [Baris et al, 1979] or to asbestos at school [Picklesimer et al, 2005], or any evidence of exposure [Hirsch et al, 1982;Munoz et al, 1988]. Two further subjects belonging to the clusters reported by Milne, 1976 andby Precerutti et al, 1990 Asbestos exposure and familial data on subjects with mesothelioma were obtained from the Apulian Registry.…”

“…Eight clusters involved only women [Li et al, 1978;Vianna and Polan, 1978;Munoz et al, 1988;Dawson et al, 1992;Ascoli et al, 1998;Bisconti et al, 2000;Musti et al, 2002;Bianchi et al, 2004;Serio et al, 2004]. All clusters included first-degree relatives and three of them involved also second-degree relatives [Li et al, 1989;Precerutti et al, 1990;Ascoli et al, 1998]. Only one cluster with heavy exposure involved the triple relationship mother, father and son [Otte et al, 1990].…”

Asbestos Burden Predicts Survival in Pleural Mesothelioma

“…Further, widespread exposures to asbestos, particularly environmental exposures in some parts of the world, combined with the rare incidence of mesothelioma, suggest that there may be susceptible individuals. In fact, multiple reports indicate that genetics may modify susceptibility to MPM (Ascoli et al 1998; Dawson et al 1992; Dogan et al 2006; Hammar et al 1989; Li et al 1978; Lynch et al 1985; Martensson et al 1984; Otte et al 1990; Precerutti et al 1990; Risberg et al 1980). When closely examining our asbestos fiber burden data, we found that most of the cases within the low-asbestos-burden group (0–99 ABs/g lung) had AB counts within the general population mean of 0–20 ABs/g lung (Dodson and Atkinson 2006); thus these patients may have a greater inherent susceptibility.…”