Is There a Differential Impact of Fatigue and Physical Disability on Quality of Life in Multiple Sclerosis?

Merkelbach, S.; Sittinger, Helmut; Koenig, Jochem

doi:10.1097/00005053-200206000-00007

Cited by 94 publications

(74 citation statements)

References 25 publications

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“…Only the SDMT was retained in the models predicting psychosocial and overall HRQOL, with lower scores on the SDMT significantly predicting poor psychosocial HRQOL and poor overall HRQOL. Our data regarding the EDSS and its relationship with physical components of HRQOL are consistent with previous research, [10][11][12][13][14][15] while the meaning of cognition as a predictor warrants further exploration. The findings suggest the possibility of a greater role for cognitive impairment in HRQOL among MS patients, and require replication in larger patient samples with other HRQOL outcomes.…”

Section: Discussionsupporting

confidence: 90%

“…3,4 This problem is of great interest in the comprehensive care of MS patients, particularly as HRQOL and adjustment to illness may help predict disease progression 4 (eg, through influencing susceptibility to relapses, engagement in positive health behaviors, use of active coping strategies, and so on). Previous research in MS has shown associations between poor HRQOL and progressive disease course, [5][6][7][8][9] greater physical disability, [10][11][12][13][14][15] disease duration, 10 fatigue, 11,12,16,17 and depression. 3,6,[17][18][19][20][21] Of these, physical and cognitive capacity are measured by performance-based reliable measures, and it is not clear which ability domain is most critical for poor HRQOL in MS patients.…”

mentioning

confidence: 96%

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Cognition and Physical Disability in Predicting Health-Related Quality of Life in Multiple Sclerosis

Hoogs

Kaur

Smerbeck

et al. 2011

International Journal of MS Care

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Many studies have shown that multiple sclerosis (MS) has a significant impact on patient healthrelated quality of life (HRQOL), but the relative contributions of physical versus cognitive disability are not well established. Most studies have relied on HRQOL outcomes that depend largely on patient mood, life satisfaction, and personal happiness. The Sickness Impact Profile (SIP) is a measure of HRQOL known for its relatively strong emphasis on task completion and activities of daily living. As such, the SIP may be less influenced by depression. We sought to determine the relative influence of physical disability and cognition, above and beyond demographic and disease variables, in predicting HRQOL. Patients (n = 132) and healthy controls (n = 26) underwent complete neuropsychological evaluation using the Minimal Assessment of Cognitive Function in MS (MACFIMS) battery and a series of self-report measures assessing depression, fatigue, and HRQOL. The SIP was also administered. Correlation analysis and group comparisons revealed significant associations between cognition and HRQOL outcomes. Logistic regression models comparing the Expanded Disability Status Scale (EDSS) and cognitive tests in predicting poor physical HRQOL retained both EDSS and Symbol Digit Modalities Test (SDMT) performance, while models predicting poor psychosocial and poor overall HRQOL retained only the SDMT. These findings support cognition as a significant predictor of overall HRQOL, psychosocial HRQOL, and, interestingly, physical HRQOL. Int J MS Care. 2011;13:57-63.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 96%

Cognition and Physical Disability in Predicting Health-Related Quality of Life in Multiple Sclerosis

Hoogs

Kaur

Smerbeck

et al. 2011

International Journal of MS Care

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“…This scale was first designated in 1995 for patients suffering from MS. Validity and reliability of this scale have been verified at the correlation-coefficient of 0.86 in foreign and domestic studies (18)(19)(20).…”

Section: Methodsmentioning

confidence: 88%

Relationship between spiritual well-being and quality of life in multiple sclerosis patients

Nasiry

Bagheri-Nesami

Shafaroudi

2016

J Nurs Midwifery Sci

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Background and Purpose: Spiritual health is one of the most critical health dimensions with remarkable influence on the life of individuals. Religion and spirituality play a pivotal role incoping with stressful events in life. This study aimed to evaluate the relationship between spiritual health and quality of life in patients with multiple sclerosis (MS). Pearson's correlation-coefficient. Methods Results:In this study, the majority of MS patients (71.7%, n=160) had average spiritual health, and mean score of quality of life was 50.2±12. Moreover, significant correlationswere observed between the total score of quality of life with dimensions of existential health (P<0.0001, r=0.97), religious health (P<0.0001, r=0.95), and total score ofspiritual health (P<0.0001, r=0.97). Conclusion:According to the results of this study, spiritual health and religious beliefs could improve the quality of life in MS patients.Spiritual health is inherent to the quality of life of patients suffering from chronic diseases, such as MS. In Iran, ideational and religious doctrines remarkably influence people's lives. Therefore, provision of culture-based and meaning-orientated care and adopting a wholesome attitude towards different aspects of MS could help medical professionals to offer the required services for these patients.

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“…The validity of these results is further strengthened by the fact that the VFQ has been established as a sensitive and useful tool to assess visual function in patients with MS. 42,43 Separate studies have suggested that HRQOL in MS is significantly affected by impairment and disability measured by the EDSS, 3 cognitive impairment, 44 and fatigue. 7 Depression has also been shown to have a strong association with HRQOL in MS, independent of clinical course and disability. [45][46][47] The results of this study corroborated prior evidence, as disability (as measured by the GNDS) and depressive symptoms (as measured by the CESD) both had a strong and significant influence on HRQOL.…”

Section: Factors Affecting Hrqol In Msmentioning

confidence: 99%

“…Among these variables, only neurologic disability, fatigue, and depression have been shown to contribute independently to overall HRQOL. [6][7][8] An association between visual function and HRQOL has also been noted in the literature, 9,10 but visual impairment was not assessed using standardized measures of vision-related health status, such as the Visual Function Questionnaire (VFQ). Rather, these studies used the visual subscale of general or functional status measures to correlate with overall QOL scores.…”

mentioning

confidence: 97%

Impact of Visual Impairment on Health-Related Quality of Life in Multiple Sclerosis

Pawar¹,

Pawar²,

Miller³

et al. 2010

International Journal of MS Care

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The aim of this study was to evaluate the impact of visual impairment on health-related quality of life (HRQOL) in patients with multiple sclerosis (MS). Patients at an outpatient MS clinic were asked to complete a battery of patient-reported outcome questionnaires. Health-related quality of life was measured using the Hamburg Quality of Life Questionnaire for Multiple Sclerosis (HAQUAMS), while visual impairment was measured using the Visual Function Questionnaire (VFQ). Hierarchical regression was used to determine the relative contribution of visual impairment to HRQOL. Usable responses were obtained for 116 MS patients. Those with higher levels of visual impairment (lower scores on the VFQ) reported significantly lower HRQOL (β = –0.01, P = .0007). Visual impairment also explained an additional 4% variance in the HRQOL scores, independent of disability and depression (ΔR2 = 0.04, F7,108 = 36.58). Overall, disability was the strongest predictor of HRQOL, explaining over 60% of the variation in HRQOL scores. The model explained 70% of the total variance in HRQOL. Given the prevalence of visual impairment and its influence on overall HRQOL, MS patients should be routinely screened using standard ophthalmic examination procedures or self-administered questionnaires such as the VFQ.

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Is There a Differential Impact of Fatigue and Physical Disability on Quality of Life in Multiple Sclerosis?

Cited by 94 publications

References 25 publications

Cognition and Physical Disability in Predicting Health-Related Quality of Life in Multiple Sclerosis

Cognition and Physical Disability in Predicting Health-Related Quality of Life in Multiple Sclerosis

Relationship between spiritual well-being and quality of life in multiple sclerosis patients

Impact of Visual Impairment on Health-Related Quality of Life in Multiple Sclerosis

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