Is There a Difference in the Prevalence of Gastroesophageal Reflux Disease between Peritoneal Dialysis and Hemodialysis Patients?

Song, Hyun Jung; Kim, Sun Moon; Lee, Yu Mi; Hwang, Jaehoon; Moon, Kyung Min; Moon, Chang Gi; Koo, Hoon Sup; Song, Kyung Ho; Kim, Yong Seok; Lee, Tae Hee; Huh, Kyu Chan; Choi, Young Woo; Kang, Young Woo; Hwang, Won Min; Yun, Sung Ro

doi:10.4166/kjg.2013.62.4.206

Cited by 6 publications

(8 citation statements)

References 20 publications

(12 reference statements)

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“…GERD is a common upper gastrointestinal disorder in patients with CKD (77.5%) and kidney transplant (75%) patients than normal population (38.6%) with the same upper gastrointestinal symptoms, while HP infection was lower (40, 36.1 and 75%, respectively). Although there was no significant difference between the prevalences of GERD (33.3 and 39.5%), erosive reflux esophagitis (16.7 and 23.7%) and non-erosive reflux disease (16.7 and 13.2%) in PD and HD, respectively, their prevalences were higher than those of the general population [32][33][34]. CKD, PD, gastrointestinal amyloidosis, immunosuppression and absence of HP infection seem to be risk factors for the development of GERD in ESRD patients [32,35].…”

Section: Discussionmentioning

confidence: 76%

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

et al. 2020

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Background Dyspepsia is a common disorder in kidney transplant recipients, and the risk of post-transplant complications is increased in candidates with upper gastrointestinal disease. We evaluated gastrointestinal lesions of kidney transplant candidates on dialysis. Methods In this study, endoscopic and pathological findings in hemodialysis (HD) and peritoneal dialysis (PD) patients with gastrointestinal symptoms on the waiting list were compared. Results The most common non-ulcerous lesions in the endoscopic examination were gastritis (62.3%), erosive gastritis (38.7%), duodenal erosion or duodenitis (18.9%) and esophagitis (13.2%). The ulcerous lesion was present in only 3 patients. Gastroesophageal reflux disease, ulcerated lesion and non-ulcerated lesion rates were similar in both dialysis groups. Histopathological examination revealed Helicobacter pylori (HP) positivity in 28.3% of patients. HP positivity rate was significantly higher in PD patients than in HD patients (38.7% vs. 13.6%, p = 0.046). Chronic gastritis (75.5%) was the most common pathological finding. HP positivity rate was 37.5% in patients with chronic gastritis, but HP was negative in patients without chronic gastritis. In multivariate analysis, male gender, urea and albumin levels were associated with the presence of pathological chronic gastritis. The presence of gastritis, total cholesterol and ferritin levels were found significant for HP positivity. A total cholesterol > 243 mg/dL was significantly related to an increased risk of the presence of HP positivity. Conclusions Gastrointestinal lesions and HP infection are common in dialysis patients. Dialysis modality may affect the frequency of some lesions. It may be useful to have an endoscopic examination before entering the transplant waiting list for all candidates.

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Section: Discussionmentioning

confidence: 76%

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

et al. 2020

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“…The high prevalence of symptoms observed in our population is consistent with that found in other studies [ 1 , 3 , 12 , 13 ]. Most studies take into account patients of all ages, so that few consider being older as a risk factor in the presence and severity of GIS [ 7 , 27 ]. However, in this study, the increase in the age range did not influence either the higher prevalence or severity of symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, the prevalence of symptoms was independent of the type of dialysis. There are inconsistencies in the literature comparing the prevalence of GIS in patients with CKD by type of dialysis [ 1 , 3 , 6 , 7 , 8 , 11 ]. These contradictions may be due to the use of different questionnaires and to the type of symptoms that they take into account since, depending on the type of dialysis, they may affect different segments of the digestive tract.…”

Section: Discussionmentioning

confidence: 99%

“…Gastrointestinal symptoms (GIS) are common among patients with end-stage renal disease (ESRD), in particular in those undergoing renal replacement therapy and with a prevalence of 32–85% [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. In México it is estimated that 28% of ESRD patients on dialysis are older than 60 years old [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between Nutritional Status and Gastrointestinal Symptoms in Geriatric Patients with End-Stage Renal Disease on Dialysis

et al. 2018

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Gastrointestinal symptoms (GIS) are common in patients with end-stage renal disease (ESRD) and are associated with nutritional risks resulting from low food intake. Little is known about the relationship between GIS and malnutrition in geriatric patients with ESRD. The main objective of this study was to determine the relationship between nutritional status and severity of GIS in geriatric patients on dialysis therapy. Clinically-stable geriatric patients (older than 60 years old) who were dialysis outpatients were included in this cross-sectional study. The severity of GIS was assessed using the Gastrointestinal Symptoms Questionnaire (GSQ, short version), with patients classified into three groups: mild, moderate, and severe. Nutritional status was evaluated with the Malnutrition Inflammation Score (MIS), anthropometric assessment, biochemical parameters, and bioelectrical impedance. Descriptive statistics were used and differences between groups were analyzed with ANOVA and Kruskal Wallis, with a p < 0.05 considered to indicate significance. Fifty patients completed the study; the median age was 67 years old. Twenty-three patients were on hemodialysis (HD) and 27 were on peritoneal dialysis (PD). No significant differences were found according to dialysis modality, presence of diabetes, or gender. Ninety percent of patients had at least one GIS. Poorer nutritional status (evaluated by MIS) was related to a higher severity of GIS. There were no significant differences with other nutritional parameters. Our study showed a high prevalence of GIS in geriatric patients. There were no differences in observed GIS values that were attributed to dialysis modality, gender, or presence of type 2 diabetes mellitus (DM2). Severe GIS values were associated with poorer nutritional status determined by MIS, however, there was no association with anthropometry, biochemical values, or bioimpedance vector analysis.

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“…There have been studies that showed the prevalence of GERD in dialysis patients was higher than that in the controls, but there was no significant difference between PD and HD patients concerning GERD and the prevalence of erosive and non-erosive reflux esophagitis [23].…”

Section: Pathophysiological Mechanisms Of Gastric Disordersmentioning

confidence: 99%

Gastrointestinal Disorders in Peritoneal Dialysis Patients

et al. 2018

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Background: Gastrointestinal (GI) disorders in peritoneal dialysis (PD) patients are relatively understudied in the literature, even though they have a serious impact in the morbidity parameters and the quality of life for this group of patients. Various diagnostic tools have been used, including instrumental methods and questionnaires, invariably validated in comparative studies. Summary: The prevalence of GI disorders is very high in PD patients. Compared to the haemodialysis patients they present a higher prevalence of reflux, eating dysfunction, gastroesophageal reflux, intestinal obstruction or adhesions and abdominal hernia. They may be divided into Gastric disorders (Gastroesophageal reflux disease, pathological Gastric emptying, Dyspepsia, Helicobacter pylori infection, peptic ulcers) and Intestinal disorders (Peritonitis, Diverticulosis, Constipation). Key Messages: The current paper is a review of the literature involving GI disorders in PD patients. This special group of patients with a special role of the peritoneal cavity and the GI motility in the physiology of their dialysis merit a larger number of studies dealing with the interrelation of the GI tract and the PD physiological, functional and pathophysiological parameters.

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Is There a Difference in the Prevalence of Gastroesophageal Reflux Disease between Peritoneal Dialysis and Hemodialysis Patients?

Cited by 6 publications

References 20 publications

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Comparison of endoscopic and pathological findings of the upper gastrointestinal tract in transplant candidate patients undergoing hemodialysis or peritoneal dialysis treatment: a review of literature

Relationship between Nutritional Status and Gastrointestinal Symptoms in Geriatric Patients with End-Stage Renal Disease on Dialysis

Gastrointestinal Disorders in Peritoneal Dialysis Patients

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