Is There a Diet for Histamine Intolerance?

Kohn, Jill Balla

doi:10.1016/j.jand.2014.09.009

Cited by 14 publications

(8 citation statements)

References 5 publications

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“…Most of us only think of histamine when thinking of allergies. Indigenous fermented foods and beverages, as potential sources of probiotics, may be very therapeutic for some, while others may have an intolerance to histamine since there is no histamine free diet, and this amine, with many functions in the body, occurs naturally, and is a neurotransmitter in the central nervous system [117].…”

Section: Fermented Foods In Developing Settingsmentioning

confidence: 99%

One Health, Fermented Foods, and Gut Microbiota

Bell

Ferrão

Pimentel

et al. 2018

Foods

124

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Changes in present-day society such as diets with more sugar, salt, and saturated fat, bad habits and unhealthy lifestyles contribute to the likelihood of the involvement of the microbiota in inflammatory diseases, which contribute to global epidemics of obesity, depression, and mental health concerns. The microbiota is presently one of the hottest areas of scientific and medical research, and exerts a marked influence on the host during homeostasis and disease. Fermented foods and beverages are generally defined as products made by microbial organisms and enzymatic conversions of major and minor food components. Further to the commonly-recognized effects of nutrition on the digestive health (e.g., dysbiosis) and well-being, there is now strong evidence for the impact of fermented foods and beverages (e.g., yoghurt, pickles, bread, kefir, beers, wines, mead), produced or preserved by the action of microorganisms, on general health, namely their significance on the gut microbiota balance and brain functionality. Fermented products require microorganisms, i.e., Saccharomyces yeasts and lactic acid bacteria, yielding alcohol and lactic acid. Ingestion of vibrant probiotics, especially those contained in fermented foods, is found to cause significant positive improvements in balancing intestinal permeability and barrier function. Our guts control and deal with every aspect of our health. How we digest our food and even the food sensitivities we have is linked with our mood, behavior, energy, weight, food cravings, hormone balance, immunity, and overall wellness. We highlight some impacts in this domain and debate calls for the convergence of interdisciplinary research fields from the United Nations’ initiative. Worldwide human and animal medicine are practiced separately; veterinary science and animal health are generally neither considered nor inserted within national or international Health discussions. The absence of a clear definition and subsequent vision for the future of One Health may act as a barrier to transdisciplinary collaboration. The point of this mini review is to highlight the role of fermented foods and beverages on gut microbiota and debate if the need for confluence of transdisciplinary fields of One Health is feasible and achievable, since they are managed by separate sectors with limited communication.

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Section: Fermented Foods In Developing Settingsmentioning

confidence: 99%

One Health, Fermented Foods, and Gut Microbiota

Bell

Ferrão

Pimentel

et al. 2018

Foods

124

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“…In addition, it is important to restrict the consumption of substances that directly stimulate the endogenous release of histamine or inhibit DAO activity. 19 In general, a diet based on fresh food and the exclusion of processed, preserved or very elaborate foods is recommended. HIT is transitory in many patients, who may return to a normal diet within a few months.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is very likely that the prevalence is underestimated due to the wide variety of symptoms that are often misinterpreted by physicians and patients. 7 DAO is continuously being secreted into the intestinal lumen, so that under normal conditions histamine from food and generated by bacteria in the intestine is satisfactorily degraded by it. 8 Thus, HIT may be a condition secondary to a quantitative de cit of DAO or a functional de cit of DAO.…”

Section: Introductionmentioning

confidence: 99%

Histamine Intolerance: Clinical Characterization and Determination of Serum Diamine Oxidase (Dao) in a Series of Cases and Controls

Peralta¹,

Bastias²,

Beltran-Ortiz³

et al. 2020

Preprint

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Introduction. Histamine intolerance (HIT) is a pathology with an estimated prevalence of 1% in which there is an imbalance between the intake of histamine via the digestive tract and the body's ability to degrade it. This results in an excessive accumulation of histamine that determines the appearance of gastrointestinal, skin, respiratory and neurological symptoms. The enzyme responsible for degrading histamine in the extracellular space is diamine oxidase (DAO); therefore, HIT is caused due to a deficit in the concentration and/or in the activity of this enzyme. Because histamine is the main mediator of the classic symptoms of IgE-mediated allergic reactions, it is difficult to differentiate a true allergy from HIT since it has basically the same clinical manifestations. Objectives. The objective of this study was to perform a clinical characterization of patients with HIT and to determine the usefulness of quantifying serum DAO concentration in the diagnosis of HIT. Method: Twenty-two patients over the age of 18 with a history of histamine intolerance were recruited, in whom IgE-mediated food allergy was ruled out, and 22 healthy patients. Both groups were surveyed and serum DAO concentration was determined. Results: Middle-aged women predominated in the population with HIT. They described a wide variety of symptoms, with a dominance of abdominal pain, bloating, diarrhea, flushing, urticaria, itching, headache and dysmenorrhea. When comparing the average serum DAO concentration in the population with HIT (10.686 U/ml) with the average obtained in the control population (20.664 U/ml), there was a significant difference (p < 0.003). Conclusion. The determination of serum DAO concentration is a useful tool for the diagnosis of HIT.

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“…Alongside the dietary measures, DAO supplementation supporting the degradation of ingested histamine is recommended as subsidiary treatment for individuals with intestinal DAO deficiency [ 9 ]. In acute and clinically more severe cases, or in cases where the ingested histamine cannot be completely removed by following the low-histamine diet [ 38 ], H 1 (or possibly H 2 ) antihistamines can be used (preferably short-term use).…”

Section: Therapeutic Approaches With Hitmentioning

confidence: 99%

“…A diet that ensures the complete elimination of histamine is unattainable [ 38 ]. The content of biogenic amines and histamine in foods differs in dependence on their source, freshness, types, pH, salt content, content of proteins (and L-histidine), processing and storage [ 13 , 23 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Histamine Intolerance—The More We Know the Less We Know. A Review

et al. 2021

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The intake of food may be an initiator of adverse reactions. Food intolerance is an abnormal non-immunological response of the organism to the ingestion of food or its components in a dosage normally tolerated. Despite the fact that food intolerance is spread throughout the world, its diagnosing is still difficult. Histamine intolerance (HIT) is the term for that type of food intolerance which includes a set of undesirable reactions as a result of accumulated or ingested histamine. Manifestations may be caused by various pathophysiological mechanisms or a combination of them. The problem with a “diagnosis” of HIT is precisely the inconstancy and variety of the manifestations in the same individual following similar stimuli. The diagnosing of HIT therefore requires a complex time-demanding multidisciplinary approach, including the systematic elimination of disorders with a similar manifestation of symptoms. Among therapeutic approaches, the gold standard is a low-histamine diet. A good response to such a diet is considered to be confirmation of HIT. Alongside the dietary measures, DAO supplementation supporting the degradation of ingested histamine may be considered as subsidiary treatment for individuals with intestinal DAO deficiency. If antihistamines are indicated, the treatment should be conscious and time-limited, while 2nd or 3rd generation of H1 antihistamines should take precedence.

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Is There a Diet for Histamine Intolerance?

Cited by 14 publications

References 5 publications

One Health, Fermented Foods, and Gut Microbiota

One Health, Fermented Foods, and Gut Microbiota

Histamine Intolerance: Clinical Characterization and Determination of Serum Diamine Oxidase (Dao) in a Series of Cases and Controls

Histamine Intolerance—The More We Know the Less We Know. A Review

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