Is there a correlation between thyroiditis and thyroid cancer?

Río, Paolo Del; Montana, Chiara; Cozzani, Federico; Rossini, Matteo; Loderer, Tommaso; Dall’Aglio, Elisabetta; Cataldo, Simona; Marina, Michela; Ceresini, Graziano

doi:10.1007/s12020-019-01935-8

Cited by 16 publications

(10 citation statements)

References 26 publications

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“…Different studies have shown an association between thyroid cancer and the presence of CAT 34,35 or higher TSH levels 36 . Although these associations are not a constant finding, 37,38 some authors have suggested a role for periodic US to detect thyroid malignancy in these situations 34 . In our population, the presence of these potential risk factors was not associated with an increased risk of thyroid nodularity or cancer.…”

Section: Discussionmentioning

confidence: 47%

Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

et al. 2021

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It has been suggested, on a theoretical basis, that ultrasound screening of thyroid nodules in obese patients with additional risk factors (family history, chronic autoimmune thyroiditis or high thyrotropin) might be cost-effective for the early detection and treatment of thyroid cancer. The present study evaluates if this approach can be validated in a real clinical setting.Methods: Patients with obesity who attended hospital-based clinics were evaluated for risk factors of thyroid cancer and ultrasound screened for thyroid nodularity.Detected nodules were evaluated according to current guidelines.Results: A total of 429 patients were evaluated (70.2% women, mean age 49.1 ± 11.0, mean body mass index 42.6 ± 5.8 kg/m 2 ). Risk factors were present in 129 (30.1%) patients. Thyroid nodules with indication for fine-needle aspiration biopsy were detected in 69 (16.1%). We did not find differences in the risk of harbouring thyroid nodules according to the presence of risk factors (no risk factors 16.6%, risk factors 14.1%, P = .64). No single risk factor conferred an increased risk for thyroid nodules During the screening procedure, four cases of thyroid cancer were detected, none of them with the evaluated risk factors. Conclusion:The presence of known risk factors for thyroid cancer does not improve the performance of a US screening strategy aimed at the detection of thyroid nodules in obese patients. According to current guidelines, screening for thyroid nodules in obese patients is not recommended regardless of the presence of thyroid cancer risk factors. What's known• Obesity increases the risk of thyroid cancer • Hypothyroidism and chronic autoimmune thyroiditis are presumed to be risk factors for thyroid cancer • It is unknown whether a thyroid nodule/cancer screening strategy in obese patients could be

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Section: Discussionmentioning

confidence: 47%

Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

et al. 2021

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“…Some studies suggest that females are more likely to have low calcium [30]. Rajinikanth et al [31] found that the high proportion of parathyroid glands in the thyroid capsule in female patients may be the reason for the high incidence of low calcium. Besides, the gender difference may be related to the effect of sex steroids on the secretion of parathyroid hormone and the genetic variation of the cell signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

The Risk Assessment of Thyroid Disorders Based on Metabonomics

Bai¹,

Liu²,

Liu³

et al. 2021

Preprint

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BackgroundWhen thyroid disorders occurred, it can disturb the balance of trace elements in human body. Therefore, the detection of trace elements during an early screening of thyroid diseases, treatment, and prognosis judgment based on personal characteristics of drugs and treatment will provide a scientific basis for clinical decision-making and can effectively reduce patients' pain and social medical burden. Methods50 healthy volunteers and 200 patients with thyroid diseases (58 cases of thyroid nodule, 59 cases of goiter, 34 cases of postoperative thyroid cancer and 24 cases of thyroid cancer) were compared in our study. Total trace elements of iodine, selenium, manganese, chromium etc. (in total 28 elements) in human serum were detected by inductively coupled plasma mass spectrometry (ICP-MS). A risk assessment model for thyroid disease was established after analyzing trace elements content, thyroid function and ultrasonography results by gender and age with the characteristics of the Chinese population. ResultsThe results showed there were significant differences in eight trace elements (I, Ca, Fe, Ni, Cu, Zn, Se, Sb) between the thyroid disease group and the healthy control group (P < 0.05). There were significant differences in ten trace elements (I, Ca, Cr, Mn, Co, Ni, Cu, Zn, Se, Sb) between the female thyroid disease group and the control group (P< 0.05). And there were significant differences in the eight trace elements (I, Mn, Fe, Ni, Cu, Zn, Se, Sb) between the male thyroid disease group and the control group (P< 0.05). There were significant correlations between the contents of FT3, FT4, T3 and T4 corresponding to iodine (P< 0.05) in thyroid disease group. Also, correlations between Fe-Zn, Cr-Mn, Ca-Zn, Ca-Se, Ca-Fe and Zn-Se (P<0.05) were found in thyroid disease group too. ConclusionsThe high concentration of iodine and manganese are risk factors of thyroid disease. In addition to the low concentration of cobalt, nickel, copper, zinc, selenium, and antimony, calcium in the serum of female patients with thyroid disease and iron in the serum of male patients with thyroid disease play a very important role. Random forest model based on element risk assessment of thyroid disease is helpful for the diagnosis and treatment of thyroid disease.

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“…Also, they were more recently reassessed in several studies conducted in consecutive patients submitted to FNA, who are believed to be less subject to potential selection bias of surgical series [35]. However, according to FNA studies, the link between PTC and HT seems less evident [18,46] Rotondi et al [19] in a 10 year follow-up study of 510 patients with CAT, who presented a negligible risk of developing thyroid carcinoma nodules.…”

Section: Discussionmentioning

confidence: 99%

“…Some reports describe a higher prevalence of benign nodules in HTthan in the general population, which is usually attributed to stimulating factors such as TSH, IGF1, and local cytokines. However, there is still controversy whether CAT predisposes to malignancy [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Hashimoto Thyroiditis and Thyroid Ultrasound: A Prospective Study

Zunino¹,

Vázquez²,

Delfino³

et al. 2021

Preprint

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Purpose We performed a prospective study in patients with positive thyroid peroxidase antibodies (TPOAb), to describe their ultrasound (US) patterns and the prevalence of thyroid nodules. Methods In 195 consecutive patients, with positive TPOAb, thyroid US was performed by the same physician and equipment and categorized into four echographic patterns (EP). We determined the prevalence of thyroid nodules and their etiology confirmed by cytology or histology. Results The median TPOAb was 526 IUI/ml. EP1 or normal US was present in 9,7%; EP2 or early/indeterminate stage in 29,4%; EP3 or established thyroiditis in 45,4% and EP4 or advanced/late stage in 15,5% of the patients. TPOAb (median = 857 UI / ml) (p = 0.001), TSH and thyroid volume were higher in EP3. A higher degree of fibrosis was associated with TPOAb > 1000 IU/ml(p = 0,003). Thyroid nodules were reported on US at 47,2% of HT. Fine needle aspiration(FNA) was performed in 49/60 nodules. Cytology: BII: 41 patients (83,7%), B V: 1 patient (2%): suspicious for lymphoma; B VI: 3 patients(6,1%) : Papillary thyroid carcinoma. Benign cytology was present in 56% of EP3 (p = 0,048). Conclusions Higher TPOAb, TSH levels, and thyroid volume were associated with EP3. Fibrosis correlated with TPOAb > 1000 IU/ml. In our population, benign nodules were associated with established thyroiditis patterns. The increased inflammation and immunological activity of Hashimoto thyroiditis (HT) could be a favorable environment for growth factors for benign nodular development.

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Is there a correlation between thyroiditis and thyroid cancer?

Cited by 16 publications

References 26 publications

Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

Presence of risk factors for thyroid cancer does not improve the performance of ultrasound screening for thyroid nodules in patients with obesity

The Risk Assessment of Thyroid Disorders Based on Metabonomics

Hashimoto Thyroiditis and Thyroid Ultrasound: A Prospective Study

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