Is there a correlation between OSAS duration/severity and carotid intima-media thickness?

Ciccone, Marco Matteo; Scicchitano, Pietro; Mitacchione, Gianfranco; Zito, Annapaola; Gesualdo, Michele; Caputo, Paola; Damiani, Mario Francesco; Sassara, Marco; Favale, Stefano; Resta, Onofrio; Carratù, Pierluigi

doi:10.1016/j.rmed.2011.12.016

Cited by 53 publications

(48 citation statements)

References 31 publications

(37 reference statements)

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“…An important tool for evaluating early impairment of the vascular structures leading toward a systemic atherosclerotic process is the IMT evaluation. 29 In our study, C-IMT values are increased in the IH and the emphysema group, whereas those in the overlap group are the highest, which suggests clinically that patients with the combination of COPD and OSA may have a worse vascular prognosis than patients who have only one of these diseases. Within the vasculature, the release of pro-inflammatory cytokines, chemokines, and growth factors by inflammatory cells causes proliferation and migration of smooth muscle cells from the media to the intima, as well as recruitment of new immunoinflammatory cells from circulation.…”

Section: Discussionsupporting

confidence: 44%

Systematic and Endothelial Inflammation and Endothelial Progenitor Cell Levels in Emphysematous Rats Exposed to Intermittent Hypoxia

et al. 2015

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Section: Discussionsupporting

confidence: 44%

Systematic and Endothelial Inflammation and Endothelial Progenitor Cell Levels in Emphysematous Rats Exposed to Intermittent Hypoxia

et al. 2015

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“…PWV has been shown to be faster among SAS patients than among control subjects [3]. In addition, AHI is known to be related to calcification of the coronary artery [4], the duration of SAS is related to IMT [5], and the severity of SAS is associated with IMT [6]. In the present study, our findings did not show a relationship between PWV, IMT or ABI and the severity of SAS.…”

Section: Discussioncontrasting

confidence: 64%

“…Some researchers have also suggested that SAS is related to atherosclerosis [3,4,5,6], which is a risk factor for CVD and death [7]. However, few papers describe such associations in human subjects, and which of the parameters of atherosclerosis are most strongly associated with the severity of SAS remains unknown; thus, it is clinically important to clarify how SAS induces atherosclerosis of the carotid artery.…”

Section: Introductionmentioning

confidence: 99%

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Association between Plaque Score of the Carotid Artery and the Severity of Sleep Apnea Syndrome in Patients with Chronic Kidney Disease

et al. 2016

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Background: Recently, sleep apnea syndrome (SAS) has been associated with hypertension, cardiovascular disease and death. Patients with chronic kidney disease (CKD) have higher rates of SAS, atherosclerotic complications and death than do patients without CKD. Although the relationship between SAS and atherosclerosis is well known, few papers have described this relationship in humans, especially in CKD patients. Patients and Methods: This was a cross-sectional study of 110 clinically stable, non-dialysis patients with CKD who attended a CKD educational program from April 2014 to September 2015. The diagnosis of SAS and its severity were assessed using a type 3 portable monitor. Other atherosclerosis-related data were obtained from the patients' medical records in order to determine the factors associated with the severity of SAS. Results: 95 men and 15 women with a mean age of 71.4 ± 9.9 years were included in the study. The patients' mean body mass index was 24.0 ± 3.9, their mean blood pressure 134.3 ± 21.2/73.6 ± 13.4 mm Hg and their mean estimated glomerular filtration rate 19.8 ± 9.5 ml/min/1.7 m². Adjusted plaque score was a significant predictor of severe SAS (odds ratio = 1.13, p = 0.0182). Mixed plaque was significantly associated with severe SAS (correlation ratio = 0.48, p < 0.0001). Conclusions: Many patients with CKD also have SAS. Our findings demonstrate the relationship between plaque score and the severity of SAS.

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“…Increased CIMT is not synonymous with atherosclerosis, but the primary pathophysiological mechanisms are similar between the two conditions 13. Ciccone et al 17 reported a positive relationship between CIMT and the duration of OSA. Increased CIMT is related with high risk CVDs,18 cardiovascular incidents19 and more serious coronary atherosclerosis 20.…”

Section: Discussionmentioning

confidence: 99%

Influence of Obstructive Sleep Apnea on Ischemia-Modified Albumin Levels and Carotid Intima-Media Thickness

Karamanli¹,

Kiyici

Arik

et al. 2016

Journal of Investigative Medicine

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Obstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88± 0.26 mm vs 0.75±0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA.

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Is there a correlation between OSAS duration/severity and carotid intima-media thickness?

Abstract: Our study shows that the duration of OSAS and its severity are important factor related with higher values of IMT and hence with a higher risk of atherosclerosis.

Cited by 53 publications

References 31 publications

Systematic and Endothelial Inflammation and Endothelial Progenitor Cell Levels in Emphysematous Rats Exposed to Intermittent Hypoxia

Systematic and Endothelial Inflammation and Endothelial Progenitor Cell Levels in Emphysematous Rats Exposed to Intermittent Hypoxia

Association between Plaque Score of the Carotid Artery and the Severity of Sleep Apnea Syndrome in Patients with Chronic Kidney Disease

Influence of Obstructive Sleep Apnea on Ischemia-Modified Albumin Levels and Carotid Intima-Media Thickness

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