Is There a Causal Link Between Periodontitis and Cardiovascular Disease? A Concise Review of Recent Findings

Febbraio, Maria; Roy, Christopher Bryant; Levin, Liran

doi:10.1016/j.identj.2021.07.006

Cited by 19 publications

(12 citation statements)

References 81 publications

(160 reference statements)

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“…There are includes direct and indirect pathogenetic mechanisms [ 34 ]. A number of review articles discuss in detail the pathogenesis of ASCVD in patients with PD [ 28 , 32 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. The most important pathogenetic mechanisms linking PD to ASCVD are summarized in Figure 2 .…”

Section: Periodontal Disease and Atherosclerosis: Pathogenesismentioning

confidence: 99%

Unexpected Relationships: Periodontal Diseases: Atherosclerosis–Plaque Destabilization? From the Teeth to a Coronary Event

Czerniuk

Surma

Romańczyk

et al. 2022

Biology

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Atherosclerotic cardiovascular disease (ASCVD) and periodontal disease (PD) are global health problems. High frequency of ASCVD is associated with the spread of many risk factors, including poor diet, sedentary lifestyle, diabetes, hyperlipidemia, obesity, smoking, hypertension, chronic kidney disease, hypertension, hyperhomocysteinemia, hyperuricemia, excessive stress, virus infection, genetic predisposition, etc. The pathogenesis of ASCVD is complex, while inflammation plays an important role. PD is a chronic, multifactorial inflammatory disease caused by dysbiosis of the oral microbiota, causing the progressive destruction of the bone and periodontal tissues surrounding the teeth. The main etiological factor of PD is the bacteria, which are capable of activating the immune response of the host inducing an inflammatory response. PD is associated with a mixed microbiota, with the evident predominance of anaerobic bacteria and microaerophilic. The “red complex” is an aggregate of three oral bacteria: Tannerella forsythia Treponema denticola and Porphyromonas gingivalis responsible for severe clinical manifestation of PD. ASCVD and PD share a number of risk factors, and it is difficult to establish a causal relationship between these diseases. The influence of PD on ASCVD should be treated as a factor increasing the risk of atherosclerotic plaque destabilization and cardiovascular events. The results of observational studies indicate that PD significantly increases the risk of ASCVD. In interventional studies, PD treatment was found to have a beneficial effect in the prevention and control of ASCVD. This comprehensive review summarizes the current knowledge of the relationship between PD and ASCVD.

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Section: Periodontal Disease and Atherosclerosis: Pathogenesismentioning

confidence: 99%

Unexpected Relationships: Periodontal Diseases: Atherosclerosis–Plaque Destabilization? From the Teeth to a Coronary Event

Czerniuk

Surma

Romańczyk

et al. 2022

Biology

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“…The biological pathways by which periodontitis accelerates vascular diseases have not been fully elucidated so far. To date, there are three plausible hypotheses, including the bacteriological, inflammatory, and immunological theories (Hajishengallis, 2015;Febbraio et al, 2022).…”

Section: The Mechanism Of Periodontitis Affecting Vascular Endothelia...mentioning

confidence: 99%

The impact of periodontitis on vascular endothelial dysfunction

Ouyang

2022

Front. Cell. Infect. Microbiol.

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Periodontitis, an oral inflammatory disease, originates from periodontal microbiota dysbiosis which is associated with the dysregulation of host immunoinflammatory response. This chronic infection is not only harmful to oral health but is also a risk factor for the onset and progress of various vascular diseases, such as hypertension, atherosclerosis, and coronary arterial disease. Vascular endothelial dysfunction is the initial key pathological feature of vascular diseases. Clarifying the association between periodontitis and vascular endothelial dysfunction is undoubtedly a key breakthrough for understanding the potential relationship between periodontitis and vascular diseases. However, there is currently a lack of an updated review of their relationship. Therefore, we aim to focus on the implications of periodontitis in vascular endothelial dysfunction in this review.

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“…Its progression results in the reduction of blood flow and consecutive ischemia of organs and tissues and promotes clot formation [21]. The American Heart Association pointed out the relationships between periodontitis and CVD although causality remains unproven [22,23].…”

Section: Pathogenetic Mechanisms Linking Periodontitis and Cvdmentioning

confidence: 99%

Periodontitis and Heart Disease: Current Perspectives on the Associative Relationships and Preventive Impact

Roman¹,

Şoancă²,

Caloian³

et al. 2022

Dentistry

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Due to the important advancement and the accumulation of new evidence on the periodontitis-cardiovascular disease (CVD) relationship as well as the major medical, economic and social burden caused by both diseases this chapter aims to review existing epidemiological and pathogenetic links related to this topic. Also, this chapter aims to highlight the impact of the periodontitis-CVD relationships on clinical practice and on the preventive approaches targeting to decrease the impact of periodontitis on CVD. Periodontitis is an infectious disease eliciting local and general inflammation, which leads to periodontal destruction and systemic involvement. Several pathways could explain the link between periodontitis and CVD such as bacteraemia, chronic persistent systemic inflammation and oxidative stress. The first step in the treatment of periodontitis addresses the elimination of microbial components, which lead to a decrease in local and systemic inflammation. Periodontal therapy seems to positively impact CVD. Specialists should inform patients with CVD on the negative impact of periodontitis on their systemic status and refer patients to the periodontist for an extensive examination as routine management of CVD. Some possible risks of periodontal therapy should be considered in patients undergoing antithrombotic medication.

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Is There a Causal Link Between Periodontitis and Cardiovascular Disease? A Concise Review of Recent Findings

Cited by 19 publications

References 81 publications

Unexpected Relationships: Periodontal Diseases: Atherosclerosis–Plaque Destabilization? From the Teeth to a Coronary Event

Unexpected Relationships: Periodontal Diseases: Atherosclerosis–Plaque Destabilization? From the Teeth to a Coronary Event

The impact of periodontitis on vascular endothelial dysfunction

Periodontitis and Heart Disease: Current Perspectives on the Associative Relationships and Preventive Impact

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