volume 269, issue 1, P203-209 2004
DOI: 10.1016/j.ijpharm.2003.09.007
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Abstract: This work evaluated the use of a commercially available 200 ml vessel for dissolution of five drug products with various solubilities. Each of the five drug products (four with USP monographs and one proprietary tablet formulation) was run at four different conditions (USP 25 monograph, six dosage units in single 1l vessel, 200 ml at the USP Monograph speed, and 200 ml at calculated paddle speed which matches the hydrodynamics of the USP vessel). Six dosage units in a single vessel were used as a comparison to…

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