Is the use of a 200ml vessel suitable for dissolution of low dose drug products?

Crail, Debbie J; Tunis, Adam S.; Dansereau, Richard J.

doi:10.1016/j.ijpharm.2003.09.007

Cited by 16 publications

(7 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…100 µm for the USP paddle method with 50 rpm (ε ) 0.004 m 2 /s 3 ). 21 A schematic presentation of the microeddy effect is shown in Figure 3B. 22 When the particle size is small, the particles float in a synchronized manner with the fluid.…”

Section: Sherwood Number In Each Flow Systemmentioning

confidence: 99%

“…In the case of the USP paddle method with 50 rpm and 1 L fluid volume, ε is 0.004 m 2 /s 3 . 21 The fluid dynamic model based on the Ranz-Marshall equation has been validated for a wide range of fluid and particle conditions, e.g., agitation strength, fluid and particle densities, etc. 18,20 Several empirical approximate equations have also been proposed for the dissolution in the USP paddle method.…”

Section: Characterization Of Each Dissolution Test Setup Used In Phar...mentioning

confidence: 99%

See 1 more Smart Citation

Aqueous Boundary Layers Related to Oral Absorption of a Drug: From Dissolution of a Drug to Carrier Mediated Transport and Intestinal Wall Metabolism

Sugano

2010

Mol. Pharmaceutics

View full text Add to dashboard Cite

The aqueous boundary layer (ABL) affects various aspects of oral absorption of a drug, from dissolution of the drug to the apparent K(m) value of intestinal wall metabolism and carrier mediated transport. However, the importance of ABL has often been entirely ignored in oral absorption investigation. In this minireview, the effect of ABL on oral absorption of a drug is discussed in an easy-to-understand manner. This review starts with an introduction of the boundary layer theory with many illustrations (and links to public web movies visualizing the ABL), and then discusses some specific cases of interest in pharmaceutical science, such as dissolution of floating drug particles in the USP paddle apparatus. The effect of the boundary layer on the membrane permeation is also discussed from the viewpoint of structure permeability relationship, carrier mediated transport/metabolism and estimation of the fraction of a dose absorbed for poor solubility compounds.

show abstract

Section: Sherwood Number In Each Flow Systemmentioning

confidence: 99%

Section: Characterization Of Each Dissolution Test Setup Used In Phar...mentioning

confidence: 99%

Aqueous Boundary Layers Related to Oral Absorption of a Drug: From Dissolution of a Drug to Carrier Mediated Transport and Intestinal Wall Metabolism

Sugano

2010

Mol. Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Agitation strength in the mini-scale dissolution test (50 rpm, mini-paddle) corresponds to 10-15 rpm in the 900 mL-scale paddle method. 131) Miniaturization reduced the sample consumption. The mini-scale dissolution test requires only a few milligrams of materials.…”

Section: Solubility Measurement Using Dmso Stock Solution (Dmso Solutmentioning

confidence: 99%

Solubility and Dissolution Profile Assessment in Drug Discovery

Sugano

Okazaki

Sugimoto

et al. 2007

Drug Metabolism and Pharmacokinetics

179

142

View full text Add to dashboard Cite

The purposes of the review are to: a) Provide a comprehensible introduction of the-state-of-the-art sciences of solubility and dissolution, b) introduce typical technologies to assess solubility and dissolution, and c) propose the best practice strategy. The theories of solubility and dissolution required in drug discovery were reviewed especially from the view point of oral absorption. The physiological conditions in the gastrointestinal fluid in humans and animals were then briefly summarized. Technologies to assess solubility and dissolution in drug discovery were then introduced. Recently, these technologies have been improved by the laboratory automation and computational technologies. Finally, the strategies to apply these technologies for a drug discovery project were discussed.

show abstract

“…The majority of studies to date have been fuelled by the need of industry to identify dissolution testing apparatuses and conditions that give reliable and reproducible results on specific formulations. [51][52][53] Computational fluid dynamics (CFD) has been used to model and predict the operating flow field both in the human stomach 54 and in the paddle [55][56][57] and flow-through cell apparatuses. 58,59 CFD results have contributed to explaining relationships observed empirically between drug release profiles and operating parameters, such as tablet positioning, mixing rate and operating flow rate.…”

Section: Introductionmentioning

confidence: 99%