Is the Treatment with Biological or Non-biological DMARDS a Modifier of Periodontal Condition in Patients with Rheumatoid Arthritis?

Romero-Sánchez, Consuelo; Rodríguez, C; Santos-Moreno, P.; Mesa, Ana María; Lafaurie, Gloria Inés; Giraldo-Q, S; Ávila, Juliette De; Castillo, Diana Marcela; Durán, Maria Antònia; Chalem, Philippe; Gualtero, Juan Manuel Bello; Valle-Oñate, Rafael

doi:10.2174/1573397113666170407161520

Cited by 36 publications

(32 citation statements)

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“…In a previous study of this working group no significant influence of different immunosuppressive rheumatic medications on finding of periodontal pathogenic bacteria could be determined . In another study an association between medication and periodontal bacteria could be found, such that Td was particularly prevalent if TNF‐α antagonists was applied . The current study found differences in the prevalence of periodontal bacteria between subgroups but could not confirm these results.…”

Section: Discussioncontrasting

confidence: 80%

“…Consistent with this finding, different anti‐inflammatory and/or immunosuppressive drugs might influence both RA and periodontal inflammation. In this context, a recent cohort study reported that different pharmacological treatment regimens for RA could influence both diseases; clinical and microbiological symptoms observed in periodontal disease patients . Several studies have addressed the effect of different RA‐related medications on periodontal disease severity and periodontal inflammation .…”

Section: Introductionmentioning

confidence: 99%

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Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: Results from a cross‐sectional study

Ziebolz

Rupprecht

Schmickler

et al. 2018

Journal of Periodontology

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Section: Discussioncontrasting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: Results from a cross‐sectional study

Ziebolz

Rupprecht

Schmickler

et al. 2018

Journal of Periodontology

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“…In the non‐randomized clinical studies there is a general concordance that the anti‐TNF‐α therapy reduces alveolar bone loss and improves periodontal indices in patients who are not under periodontal treatment . However, two studies did not support these findings.…”

Section: Resultsmentioning

confidence: 99%

“…Quality of information in non‐randomized clinical studies was considered high level in seven articles and moderate in the remaining studies . Quality of information in the In vivo animal studies was considered moderate in five articles and high in seven studies .…”

Section: Resultsmentioning

confidence: 99%

Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review

Peddis

Musu

Ideo

et al. 2019

Australian Dental Journal

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Biologic medications (BMs) are increasingly used for the management of systemic chronic inflammatory diseases. These diseases are often associated with a higher prevalence of apical periodontitis (AP) and periodontitis (P). The purpose of this systematic review was to ascertain the interactions between AP and/or P and BMs. The review was registered in the PROSPERO database (CRD42017054756). Electronic searches were performed on Pubmed Medline, Scopus and The Web of Science from their inception through to 20 March 2018. The references of the articles selected were checked. The keywords were chosen based on a pilot search, which aimed to find the most frequently prescribed BMs. The included studies were appraised qualitatively using appropriate tools. Thirty-five articles met the inclusion criteria, comprising 16 non-randomized clinical studies, 12 in vivo animal studies and 7 case reports. Quality of information was assessed as high in 18 articles, moderate in 16 articles and low in 1 article. BMs in patients suffering from chronic inflammatory diseases seems to inhibit the progression of AP and P, and to enhance the healing response to periodontal and endodontic treatment. A healthier condition of the periodontal tissues seems to be associated with a better response of the patient to BMs therapy.Abbreviations and acronyms: AP = apical periodontitis; BM = biologic medications; P = periodontitis; RANKL = receptor activator of nuclear factor kappa-Β ligand (RANKL).

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“… 27 28 A recent study, for instance, has suggested that conventional DMARDs may have a modifying effect on the periodontal condition in patients with RA: patients receiving the combination of methotrexate plus leflunomide had worse CAL. 29 …”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between spondyloarthritis and periodontitis? A case–control study

et al. 2017

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ObjectiveTo compare the frequency and severity of periodontitis in patients with spondyloarthritis (SpA) with healthy control individuals, through the evaluation of clinical, serological and microbiological periodontal condition.MethodsPatients with a diagnosis of SpA (n=78) and biological disease-modifying antirheumatic drug (bDMARD) naive fulfilling the Assessment of SpondyloArthritis international Society (ASAS) classification criteria as well as 156 healthy controls matched for age/gender were included. Two trained and calibrated periodontologists performed the periodontal clinical assessment. The presence of periodontitis and its severity were determined according to the criteria established by the Centers for Disease Control and Prevention-American Academy of Periodontology. The clinical periodontal variables, IgG1/IgG2 antibodies against Porphyromonas gingivalis andperiodontopathic bacterial identification, were also established. Comparisons of periodontal characteristics between the patients with SpA and the control group were performed using univariable analyses. A logistic regression analyses was performed to calculate the OR (95% CI) for diagnosis of periodontitis in patients with SpA and matched controls.ResultsA diagnosis of periodontitis was established in 56% in patients with SpA versus 69% of healthy controls (P≤ 0.01). Severe periodontitis was found in 3% versus 12% in SpA versus healthy controls, respectively (P≤ 0.01). There was no significant increase of frequency of any periodontal variable, IgG1/IgG2 antibodies against P. gingivalis or the presence of periodontopathic bacteria between patients with SpA and control group. Periodontitis was not positively associated with a diagnosis of SpA (OR: 0.57, 95% CI 0.32 to 1.00, P=0.05) in the logistic regression analyses.ConclusionsWe found a lower rather than a higher frequency and severity of periodontitis in patients with SpA in comparison with healthy control individuals. Our findings suggest that there is no positive association between SpA and periodontitis in Colombian patients.

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Is the Treatment with Biological or Non-biological DMARDS a Modifier of Periodontal Condition in Patients with Rheumatoid Arthritis?

Abstract: Different pharmacological treatments for RA affect the clinical condition and subgingival microbiota.

Cited by 36 publications

References 0 publications

Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: Results from a cross‐sectional study

Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: Results from a cross‐sectional study

Interaction of biologic therapy with apical periodontitis and periodontitis: a systematic review

Is there a relationship between spondyloarthritis and periodontitis? A case–control study

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