Is the risk of idiopathic sudden sensorineural hearing loss higher in nasopharyngeal carcinoma than in hypopharyngeal cancer? A population-based study

Abstract

Background: The aim of this study was to compare the risk of developing sudden sensorineural hearing loss (SSHL) in patients with hypopharyngeal cancer with that in patients with nasopharyngeal carcinoma (NPC). Methods: A population-based, retrospective cohort study was performed using the Taiwan National Health Research Database databank. Patients selected for this study were diagnosed with hypopharyngeal cancer or NPC and treated with radiotherapy in the period from 2001 to 2004. Routine follow-up was conducted for 8 years (2004–2012), and the incidence of SSHL was calculated at the final follow-up. Results: There was no significant difference in the risk of developing SSHL between the hypopharyngeal cancer group and its control group ( p = 1.000). In hypopharyngeal cancer and NPC groups, the rates of SSHL were 0.12% and 1.00%, respectively ( p < 0.001). The cumulative hazard of SSHL during the follow-up period was significantly higher in the NPC group than in the control group ( p < 0.001). Conclusion: Radiotherapy in patients with hypopharyngeal cancer did not increase the risk of developing SSHL, but postirradiation NPC was significantly associated with an increased incidence of SSHL.

Digestion-Specific Acupuncture Effect on Feeding Intolerance in Critically Ill Post-Operative Oral and Hypopharyngeal Cancer Patients: A Single-Blind Randomized Control Trial

“…This can be rationalized according to the fact that the study population of oral cancer patients and hypopharyngeal cancer are predominately males [ 51 , 52 , 53 ]. Furthermore, the male prevalence in oral and hypopharyngeal cancers is even more profound in the Taiwanese population [ 54 , 55 ]. Thus, the interpretation of the results should reflect this detail accordingly, and the treatment efficacy should not immediately be generalized to influence all gender populations.…”

Post-Therapy Sense of Taste Disorders in Nasopharyngeal Carcinoma

“…Side effects that appear can occur immediately or slowly, can occur locally or generally, and can occur from mild to severe (Santoso et al, 2009). Radiation therapy in nasopharyngeal cancer can cause several side effects such as mucositis, salivary gland dysfunction, taste dysfunction and malnutrition, dental disorders, bone changes, cutaneous changes, nerve damage, intellectual decline, hearing loss, the occurrence of malignant cancer due to radiation and bleeding Brain (Chang et al, 2020). Based on this, the authors are interested in discussing taste disorders in posttherapy for nasopharyngeal carcinoma (Kemenkes, 2017).…”