Is the prevalence of peanut allergy increasing? A 5-year follow-up study in children in Montreal

Ben‐Shoshan, Moshe; Kagan, Rhoda; Alizadehfar, Reza; Joseph, Lawrence; Turnbull, Elizabeth; Pierre, Yvan St.; Clarke, Ann E.

doi:10.1016/j.jaci.2009.02.004

Cited by 99 publications

(78 citation statements)

References 37 publications

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“…Hence, it is possible that the factors identified in the regression analysis are not valid predictors of a confirmed food allergy (based on the corroboration of history with confirmatory tests). However, given that previous studies by our group reveal that probable peanut allergy estimates in Canadian and Quebec children (Canada: 1.68%; Quebec: 1.69%) are consistent with confirmed peanut allergy estimates in Montreal schoolchildren (1.63%) [7,36] , we believe that the associations identified for probable allergy are also valid for confirmed allergy. There may be a differential recall bias by individuals with food allergy, such that they are more prone to remembering eczema in early life.…”

Section: Discussionsupporting

confidence: 82%

“…In line with this hypothesis, recent studies suggest that controlling eczema might reduce the risk of food sensitization and, potentially, allergy [34,35] . Indeed, recent studies suggest that food allergy may not be increasing in developed countries [36,37] over the past decade, and it is possible that better treatment of eczema may explain this stabilization.…”

Section: Discussionmentioning

confidence: 99%

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Eczema in Early Childhood, Sociodemographic Factors and Lifestyle Habits Are Associated with Food Allergy: A Nested Case-Control Study

Ben‐Shoshan¹,

Soller

Harrington

et al. 2015

Int Arch Allergy Immunol

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tion between atopy, sociodemographic characteristics and lifestyle habits with probable food allergy. Results: Between September 2010 and September 2011, 480 cases and 4,950 controls completed the questionnaire. For all 9 allergens, factors associated with a higher risk of probable allergy were as follows: (1) personal history of eczema (in the first 2 years of life), asthma or hay fever (odds ratio, OR 2.3, 95% CI 1.6-3.5; OR 2.8, 95% CI 2.2-3.6, and OR 2.3, 95% CI 1.8-3.0, respectively), (2) maternal, paternal or sibling's food allergy (OR 3.7, 95% CI 2.5-5.6; OR 3.0, 95% CI 1.8-5.1, and OR 3.1, 95% CI 2.2-4.2), (3) high household income (top 20%; OR 1.5, 95% CI 1.2-2.0). Males and older individuals were less likely to have food allergy (OR 0.7, 95% CI 0.6-0.9, and OR 0.99, 95% CI 0.99-1.00). Eczema in the first 2 years of life was the strongest risk factor for egg, peanut, tree nut and fish allergy. Conclusions: This is the largest population-based nested casecontrol study exploring factors associated with food allergies. Our results reveal that, in addition to previously reported factors, eczema in the first 2 years of life is consistently associated with food allergies. © 2015 S. Karger AG, Basel Key WordsFood allergy · Eczema · Demographic factors · Lifestyle Abstract Background: Studies suggest an increase in food allergy prevalence over the last decade, but the contributing factors remain unknown. The aim of this study was to evaluate the association between the most common food allergies and atopic history, sociodemographic characteristics and lifestyle habits. Methods: We conducted a case-control study nested within the SPAACE study (Surveying Prevalence of Food Allergy in All Canadian Environments) -a cross-Canada, random telephone survey. Cases consisted of individuals with probable food allergy (self-report of convincing symptoms and/or physician diagnosis) to milk, egg, peanut, tree nut, shellfish, fish, wheat, soy, or sesame. Controls consisted of nonallergic individuals, matched for age. Cases and controls were queried on personal and family history of atopy, sociodemographic characteristics and lifestyle habits. Multivariate logistic regression was used to evaluate the associa-

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Eczema in Early Childhood, Sociodemographic Factors and Lifestyle Habits Are Associated with Food Allergy: A Nested Case-Control Study

Ben‐Shoshan¹,

Soller

Harrington

et al. 2015

Int Arch Allergy Immunol

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show abstract

“…40 Other studies of peanut allergy suggest modest increases in children, with perhaps a leveling off in the last decade. [41][42][43] Prevalence rates of admissions for food-induced anaphylaxis in Australia increased 350% between 1994 and 2005. Rates of increase were greater for children less than 4 years of age and for peanut and tree nut anaphylaxis, with more modest increases noted for older age groups and other allergies, such as cow's milk or egg allergy.…”

Section: Changes In Prevalence Over Timementioning

confidence: 99%

ICON: Food allergy

Burks

Tang

Sicherer

et al. 2012

Journal of Allergy and Clinical Immunology

577

522

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“…In 2002, about 0.8% of young children and 0.6% of adults were reported to be allergic to peanuts in the United States (Sampson, 2004), and this rate increased to 1.4% in 2008 (Sicherer & Sampson, 2010). In Canada, the percentage of children allergic to peanuts also increased from 1.3% in 2000-2002to 1.6% in 2005-2007(Ben-Shoshan et al, 2009). The causes for this increase remain unclear underscoring the need to develop new methods to inactivate allergens before they cause allergic reactions, especially since up to 75% of individuals with known peanut allergy experience reactions caused by accidental exposure (Kagan et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Allergenicity of roasted peanuts treated with a non-human digestive protease

Hernández

et al. 2015

Food Research International

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Is the prevalence of peanut allergy increasing? A 5-year follow-up study in children in Montreal

Cited by 99 publications

References 37 publications

Eczema in Early Childhood, Sociodemographic Factors and Lifestyle Habits Are Associated with Food Allergy: A Nested Case-Control Study

Eczema in Early Childhood, Sociodemographic Factors and Lifestyle Habits Are Associated with Food Allergy: A Nested Case-Control Study

ICON: Food allergy

Allergenicity of roasted peanuts treated with a non-human digestive protease

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