Is the prefrontal cortex organized by supramodal or modality-specific sensory demands during adolescence?

Sicard, Veronik; Stephenson, David D.; Dodd, Andrew B.; Reddy, Sharvani Pabbathi; Robertson-Benta, Cidney R; Ryman, Sephira G.; Hanlon, Faith M.; Shaff, Nicholas A.; Ling, Josef M.; Hergert, Danielle C; Vakamudi, Kishore; Hogeveen, Jeremy; Mayer, Andrew R.

doi:10.1016/j.dcn.2021.101006

Cited by 2 publications

(10 citation statements)

References 59 publications

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“…It could be theorized that because of (subclinical) difficulties in per- The right posterior lobe of the cerebellum was consistently activated by the task, irrespective of modality (Sicard et al, 2021), and the role of this area in cognition is widely known (Schmahmann, 2019). While less well known, the cerebellum can be affected by mTBI, even when the primary injury is as remote as the forebrain (Fukuda et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…The current prospective study used a multimodal attention paradigm (Sicard et al, 2021) $1 week post-injury), with normalization in the early chronic stage (EC; $4 months). Specifically, higher reaction times and/or lower accuracy were predicted for pmTBI during the attendance of visual stimuli for incongruent trials (i.e., with auditory distractors), together with increased activation of the CCN (both SN and EN).…”

Section: Introductionmentioning

confidence: 99%

“…The latter can occur either as a result of active planning of attentional allocation following a cue (i.e., proactive control) or when processing stimuli with competing attentional demands (i.e., reactive control) (Braver et al, 2009 ). Although there are areas of the CCN that are activated during both forms of cognitive control, reactive control is associated with more widespread engagement of this network (Ryman et al, 2019 ; Sicard et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Almost half a century ago, Francis Colavita demonstrated that visual information is dominant over auditory information in adults, as reflected by a bias toward visual stimuli during simultaneously presented auditory and visual stimuli (Colavita, 1974 ). A recent study has shown evidence for the Colavita effect in healthy control (HC) adolescents (Sicard et al, 2021 ) with activation of the CCN and posterior superior temporal sulcus (pSTS) for attention to visual but not auditory targets with cross‐modal distractors. During proactive control, increased CCN activity was also observed for visual versus auditory cues, while increased deactivation of the anterior DMN was found for the opposite contrast.…”

Section: Introductionmentioning

confidence: 99%

“…The current prospective study used a multimodal attention paradigm (Sicard et al, 2021 ) to study the triple‐network model in relation to cognitive control in a large ( N = 181) sample of patients with pmTBI and an age‐ and sex‐matched group of HC ( N = 162). It was hypothesized that patients with pmTBI would show enhanced reactive cognitive control as compared to HC in the sub‐acute stage (SA; ~1 week post‐injury), with normalization in the early chronic stage (EC; ~4 months).…”

Section: Introductionmentioning

confidence: 99%

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Neural correlates of cognitive control deficits in pediatric mild traumatic brain injury

van der Horn,

Dodd,

Wick

et al. 2023

Human Brain Mapping

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There is a growing body of research showing that cerebral pathophysiological processes triggered by pediatric mild traumatic brain injury (pmTBI) may extend beyond the usual clinical recovery timeline. It is paramount to further unravel these processes, because the possible long‐term cognitive effects resulting from ongoing secondary injury in the developing brain are not known. In the current fMRI study, neural processes related to cognitive control were studied in 181 patients with pmTBI at sub‐acute (SA; ~1 week) and early chronic (EC; ~4 months) stages post‐injury. Additionally, a group of 162 age‐ and sex‐matched healthy controls (HC) were recruited at equivalent time points. Proactive (post‐cue) and reactive (post‐probe) cognitive control were examined using a multimodal attention fMRI paradigm for either congruent or incongruent stimuli. To study brain network function, the triple‐network model was used, consisting of the executive and salience networks (collectively known as the cognitive control network), and the default mode network. Additionally, whole‐brain voxel‐wise analyses were performed. Decreased deactivation was found within the default mode network at the EC stage following pmTBI during both proactive and reactive control. Voxel‐wise analyses revealed sub‐acute hypoactivation of a frontal area of the cognitive control network (left pre‐supplementary motor area) during proactive control, with a reversed effect at the EC stage after pmTBI. Similar effects were observed in areas outside of the triple‐network during reactive control. Group differences in activation during proactive control were limited to the visual domain, whereas for reactive control findings were more pronounced during the attendance of auditory stimuli. No significant correlations were present between task‐related activations and (persistent) post‐concussive symptoms. In aggregate, current results show alterations in neural functioning during cognitive control in pmTBI up to 4 months post‐injury, regardless of clinical recovery. We propose that subacute decreases in activity reflect a general state of hypo‐excitability due to the injury, while early chronic hyperactivation represents a compensatory mechanism to prevent default mode interference and to retain cognitive control.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Neural correlates of cognitive control deficits in pediatric mild traumatic brain injury

van der Horn,

Dodd,

Wick

et al. 2023

Human Brain Mapping

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Multi-modal Representation of the Size of Space in the Human Brain

Lee,

Park

2024

Journal of Cognitive Neuroscience

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To estimate the size of an indoor space, we must analyze the visual boundaries that limit the spatial extent and acoustic cues from reflected interior surfaces. We used fMRI to examine how the brain processes the geometric size of indoor scenes when various types of sensory cues are presented individually or together. Specifically, we asked whether the size of space is represented in a modality-specific way or in an integrative way that combines multimodal cues. In a block-design study, images or sounds that depict small- and large-sized indoor spaces were presented. Visual stimuli were real-world pictures of empty spaces that were small or large. Auditory stimuli were sounds convolved with different reverberations. By using a multivoxel pattern classifier, we asked whether the two sizes of space can be classified in visual, auditory, and visual–auditory combined conditions. We identified both sensory-specific and multimodal representations of the size of space. To further investigate the nature of the multimodal region, we specifically examined whether it contained multimodal information in a coexistent or integrated form. We found that angular gyrus and the right medial frontal gyrus had modality-integrated representation, displaying sensitivity to the match in the spatial size information conveyed through image and sound. Background functional connectivity analysis further demonstrated that the connection between sensory-specific regions and modality-integrated regions increases in the multimodal condition compared with single modality conditions. Our results suggest that spatial size perception relies on both sensory-specific and multimodal representations, as well as their interplay during multimodal perception.

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Is the prefrontal cortex organized by supramodal or modality-specific sensory demands during adolescence?

Cited by 2 publications

References 59 publications

Neural correlates of cognitive control deficits in pediatric mild traumatic brain injury

Neural correlates of cognitive control deficits in pediatric mild traumatic brain injury

Multi-modal Representation of the Size of Space in the Human Brain

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