Is the nail psoriasis severity index reliable in the assessment of nail psoriasis by rheumatologists?

Lubrano, Ennio; Cantini, Fabrizio; Marchesoni, Antonio; Mathieu, Alessandro; Olivieri, Ignazio; Salvarani, Carlo; Scarpa, Raffaele; Spadaro, Antonio

doi:10.1002/acr.20691

Cited by 31 publications

(31 citation statements)

References 9 publications

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“…The growing body of evidence implicating the innate immune system in the pathogenesis of OA provides hope that insights into these mechanisms might inform our ability to phenotype patients who would stand to benefit the most from a particular therapy and treat these patient subsets more specifically than is currently possible. Although currently there are few effective pharmacologic treatment options for symptomatic OA, intra-articular glucocorticoids have shown some efficacy and are recommended by a number of international treatment guidelines (70, 71). Among their many effects, glucocorticoids lower expression of complement (72, 73), and induce macrophage polarization to an anti-inflammatory phenotype (74).…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

2015

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Although mankind has been suffering from osteoarthritis (OA) dating to the dawn of humankind, its pathogenesis remains poorly understood. OA is no longer considered a “wear and tear” condition but rather one driven by proteases where chronic low-grade inflammation may play a role in perpetuating proteolytic activity. While multiple factors are likely active in this process, recent evidence has implicated the importance of the innate immune system, the older or more primitive part of our body’s immune defense mechanisms. The role of some of the components of the innate immune system have been tested in OA models in vivo including the role of synovial macrophages and the complement system. This review is a selective overview of a large and evolving field. Insights into these mechanisms might inform our ability to phenotype patient subsets and give hope for the advent of novel OA therapies.

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Section: Therapeutic Implicationsmentioning

confidence: 99%

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

2015

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“…Recommendations for initial analgesic treatment include paracetamol and topical NSAIDs (for hand and knee) ahead of oral NSAIDs including COX-2 inhibitors [93–95]. The latter should be used at the lowest effective dose, and long-term use should be avoided.…”

Section: Pain Indications Frequently Encountered By the Family Pramentioning

confidence: 99%

Tramadol/Paracetamol Fixed-Dose Combination for Chronic Pain Management in Family Practice: A Clinical Review

Merchante¹,

Pergolizzi

Laar³

et al. 2013

ISRN Family Medicine

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The family practitioner plays an important role in the prevention, diagnosis, and early management of chronic pain. He/she is generally the first to be consulted, the one most familiar with the patients and their medical history, and is likely the first to be alerted in case of inadequate pain control or safety and tolerability issues. The family practitioner should therefore be at the center of the multidisciplinary team involved in a patient's pain management. The most frequent indications associated with chronic pain in family practice are of musculoskeletal origin, and the pain is often multimechanistic. Fixed-dose combination analgesics combine compounds with different mechanisms of action; their broader analgesic spectrum and potentially synergistic analgesic efficacy and improved benefit/risk ratio might thus be useful. A pain specialist meeting held in November 2010 agreed that the fixed-dose combination tramadol/paracetamol might be a useful pharmacological option for chronic pain management in family practice. The combination is effective in a variety of pain conditions with generally good tolerability. Particularly in elderly patients, it might be considered as an alternative to conventional analgesics such as NSAIDs, which should be used rarely with caution in this population.

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“…, 2 It is an intra-articular injection of sodium hyaluronate (HA, hyaluronic acid) in the diarthrodial joints aiming to improve pain and function 3 visco-induction 4 and to delay the disease progression 5 …”

Section: Introductionmentioning

confidence: 99%

Ensaio clínico prospectivo e randomizado: regime único e semanal de viscossuplementação

et al. 2013

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OBJECTIVE: To compare two different dosages of an intermediate molecular weight sodium hyaluronate (HA) (Osteonil®-TRB Pharma) assessing whether a single 6 ml application of this HA has the same effectiveness as the classical three-weekly 2 ml dose. METHODS: 108 patients with knee osteoarthritis were randomized into two groups of 54 patients each. The groups were designated "single" (S) and "weekly" (W). Patients in group S underwent a viscosupplementation procedure by application of only 6 ml of sodium hyaluronate and 1 ml triamcinolone hexacetonide. Patients in group W underwent the procedure of viscosupplementation through three applications with 2 ml sodium hyaluronate with a week interval between them, and the first application was also performed with the infiltration of 1 ml (20 mg) of Triamcinolone Hexacetonide. Both groups were assessed before, at one month and three months after application, by responding to the WOMAC, Lequesne, IKDC and VAS questionnaires. RESULTS: There was no statistical difference between the single application of 6 ml of sodium hyaluronate and classic application with three weekly injections. However, only the classical regime showed statistically significant improvement in baseline pain (WOMAC pain and VAS). CONCLUSION: Our results suggest that both application schemes improve application function, but the three-weekly regimen of 2 ml was more effective in reducing pain. Level of Evidence I, Prospective Randomized, Clinical Trial.

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Is the nail psoriasis severity index reliable in the assessment of nail psoriasis by rheumatologists?

Abstract: Objective. To determine the agreement and reliability of the Nail Psoriasis Severity Index (NAPSI) in the assessment of nail involvement in patients with psoriatic arthritis (PsA) when performed by rheumatologists with no experience in using this instrument.

Cited by 31 publications

References 9 publications

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

Tramadol/Paracetamol Fixed-Dose Combination for Chronic Pain Management in Family Practice: A Clinical Review

Ensaio clínico prospectivo e randomizado: regime único e semanal de viscossuplementação

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