Is the longitudinal deformation of the left ventricle affected by vitamin D deficiency in nondiabetics? A 2D speckle‐tracking echocardiographic study

Omidi, Fatemeh; Hosseinsabet, Ali

doi:10.1111/echo.14205

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…Our findings confirm the diagnostic role of 2D‐STE as regards the early detrimental effects of VD deficiency on LV systolic functions. However, our results were inconsistent with Omidi and Hosseinsabet 38 who studied the longitudinal deformation of LV in 98 non‐diabetic subjects (53 subjects without VD deficiency and 45 subjects with VD deficiency) using 2D‐STE, and reported non‐significant correlations between the global longitudinal subendocardial deformations of LV and the presence or absence of vitamin D deficiency.…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of the left ventricular systolic strain in hypocalcemic infants with two‐dimensional speckle tracking echocardiography

et al. 2022

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Introduction: Speckle tracking echocardiography (STE) is a new emerging method for evaluation of the cardiac systolic performance. We characterized left ventricular (LV) systolic functions of hypocalcemic infants, and assessed the effects of calcium and vitamin D supplementations on LV systolic functions using two‐dimensional STE. Patients and Methods: A prospective controlled study was conducted in Mansoura University Children's Hospital, Egypt from 2015 to 2018 including 88 hypocalcemic infants (patient group) and 30 healthy controls. We subdivided the patient group into vitamin D deficiency group (n = 32) and normal vitamin D group (n = 56). All infants were investigated for serum phosphorus, alkaline phosphatase and 25‐hydroxy vitamin D levels. Both patients and controls were initially evaluated for LV systolic functions using two‐dimensional STE. After correction of hypocalcemia and vitamin D deficiency, reevaluation of LV systolic functions was done for the patient group. Results: LV systolic strains were lower in the patient group than controls (p < .001). After recovery of hypocalcemia of the patients, we reported significant improvement of strains and significant reductions of the end‐diastolic and end‐systolic volumes of the left ventricle (p < .001). Global longitudinal and circumferential strains were lower in patients with vitamin D deficiency than patients with normal vitamin D levels (p < .001). The LV systolic strain improved after correction of vitamin D deficiency and hypocalcemia (p < .001). Conclusion: Two‐dimensional STE could detect and follow up early LV systolic dysfunction in infants with hypocalcemia and vitamin D deficiency.

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Section: Discussioncontrasting

confidence: 99%

Evaluation of the left ventricular systolic strain in hypocalcemic infants with two‐dimensional speckle tracking echocardiography

et al. 2022

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“…VitD therapy may have positive effects on myocardial deformation (17). But in Omidi F. et al study, the global longitudinal subendocardial deformations were not statistically significantly correlated with the presence or absence of VDD (18). In addition, it was stated in a letter to the editor that age and renal insufficiency may play a role in the background of myocardial deformation in VDD (19).…”

Section: Introductionmentioning

confidence: 92%

Vitamin D Deficiency in Premenopause: Endothelial and Diastolic Functions With Hyperparathyroidism

Akhan,

Dogdus

2024

Preprint

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Introduction: Vitamin D deficiency(VDD) is a common condition in all ages worldwide, especially in winter, and causes several adverse cardiovascular outcomes. Although there is conflicting information about the causes of adverse cardiac events in VDD, the accepted leading cause is a pathogenic relationship with hyperparathyroidism. Aim: We aim to demonstrate hyperparathyroidism’s effects, if present, on endothelial and diastolic functions using echocardiography, carotid, and brachial tissue Doppler imaging (tDi) in premenopausal women with VDD independent from confounding risk factors. Methods: Our study is a cross-sectional, observational study investigating premenopausal women aged 18-50 who applied to internal medicine department. The patients are divided into two groups according to parathyroid hormone(PTH) levels (Normal PTH 41 patients, abnormal PTH 27 patients). Study groups are analyzed for basal characteristics, standard echocardiographic evaluation, carotid, and brachial artery tDi features. Results: There were no significant differences in age, height, weight, body mass index(BMI), and blood pressures between the groups (all p values>0.05). The rate of severe VDD was 76%. In terms of diastolic parameters, prolongation of A wave durations and decreased E/A ratio were observed in the secondary hyperparathyroidism (p values 0.042 and 0.031, respectively). Also, carotid IMT is significantly higher in secondary hyperparathyroidism(p=0.034). Conclusion: Our study showed that high PTH levels have adverse effects on diastolic(A wave, E/A ratio) and endothelial functions(carotid IMT) in premenopausal women diagnosed with VDD, even in the absence of other confounding risk factors. We can state that our study’s findings will contribute to the literature and are predictive for future studies.

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Vitamin D deficiency as a seed in a fertile soil: A proposed hypothesis

Davarpasand

2019

Echocardiography

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In January of 2019, the Echocardiography-a journal of cardiovascular ultrasound and allied techniques published an article entitled as "Is the longitudinal deformation of the left ventricle affected by vitamin D deficiency in nondiabetics? A 2D speckletracking echocardiographic study". 1 In that research, authors evaluated left ventricular (LV) longitudinal deformation in nondiabetic patients with and without vitamin D deficiency by 2D speckle-tracking echocardiography and found that there was no statistically significant difference between two groups regrading to deformation parameters. Although some of the subjects in two groups suffered from hypertension, the authors alleviated the effect of hypertension on LV myocardial deformation by excluding subjects with increased LV mass. In another recent study, it has been shown that there is no statistically significant difference between left atrial myocardial deformation in aforementioned two groups. 2 However, in diabetic patients, the vitamin D deficiency can lead to decreased deformation of LV myocardium. 3 It can be hypothesized that in the background of a subtle myocardial dysfunction such as diabetes, vitamin D deficiency can lead to decreased myocardial deformation in subjects with normal LV ejection fraction. There are some evidences that support this hypothesis, such as improvement of myocardial deformation in geriatric subjects with vitamin D deficiency and in pediatric subjects with chronic kidney diseases. 4,5 The age and renal diseases can play as a background role that vitamin D deficiency leads to decreased myocardial deformation. It is clear that this hypothesis is different from another hypothesis that proposes epiphenomenon role for vitamin D deficiency. 1. Omidi F, Hosseinsabet A. Is the longitudinal deformation of the left ventricle affected by vitamin D deficiency in nondiabetics? A 2D speckle-tracking echocardiographic study. Echocardiography. 2019;36:67-73. 2. Akhavan-Khaleghi N, Hosseinsabet A, Mohseni-Badalabadi R. Effects of vitamin D deficiency on left atrial function as evaluated by 2D speckle-tracking echocardiography. J Clin Ultrasound. 2018;46:334-340. 3. Chen Y, Zhao CT, Zhen Z, et al. Association of myocardial dysfunction with vitamin D deficiency in patients with type 2 diabetes mellitus. J Diabetes Complications. 2014;28:286-290. 4. Briguglio M, Gianturco L, Stella D, et al. Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery. J Geriatr Cardiol. 2018;15:519-522. 5. Deveci M, Aytaç MB, Altun G, et al. Effect of high-dose oral cholecalciferol on cardiac mechanics in children with chronic kidney disease.

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Is the longitudinal deformation of the left ventricle affected by vitamin D deficiency in nondiabetics? A 2D speckle‐tracking echocardiographic study

Cited by 4 publications

References 32 publications

Evaluation of the left ventricular systolic strain in hypocalcemic infants with two‐dimensional speckle tracking echocardiography

Evaluation of the left ventricular systolic strain in hypocalcemic infants with two‐dimensional speckle tracking echocardiography

Vitamin D Deficiency in Premenopause: Endothelial and Diastolic Functions With Hyperparathyroidism

Vitamin D deficiency as a seed in a fertile soil: A proposed hypothesis

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