Is the Level of Serum Triglyceride a Significant Predictor of Coronary Death in “Normocholesterolemic” Subjects?

Cambien, François; Jacqueson, A.; Richard, J L; Warnet, J. M.; Ducimetière, Pierre; Claude, Jean‐Roger

doi:10.1093/oxfordjournals.aje.a114435

Cited by 157 publications

(55 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, although hypertriglyceridaemia is often associated with coronary heart disease, whether hypertriglyceridaemia has an independent causal relationship with coronary heart disease has been questioned [37,38]. In several prospective studies in men, both without [39,40] or with glucose intolerance [19], plasma triglyceride levels were found to be independently associated with heart disease, but HDL cholesterol levels were not assessed.…”

Section: Discussionmentioning

confidence: 99%

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

et al. 1990

View full text Add to dashboard Cite

Summary. In a community-based study of second-generation Japanese-American men known to have a high prevalence of both Type 2 (non-insulin-dependent) diabetes and impaired glucose tolerance, there was a highly significant association of coronary heart disease with glucose intolerance in a study sample of 219 men. Intra-abdominal cross sectional fat area determined by computed tomography was significantly elevated in men with coronary heart disease even after adjustment for glucose intolerance and body mass index (p = 0.026). Other differences that were significantly related to coronary heart disease after adjustment for glucose intolerance were lower high density lipoprotein cholesterol levels (p = 0.001), elevated total triglyceride and very low density lipoprotein triglyceride (p < 0.001), and elevated fasting insulin and C-peptide levels p = 0.001. When these variables were tested in a stepwise multiple logistic regression model, significant independent associations with coronary heart disease were found only for total triglyceride and fasting C-peptide after adjustment for glucose tolerance status. Variables identified to be associated with coronary heart disease were interpreted as representing or manifesting an insulin resistant state. Thus, insulin resistance may be the underlying risk factor aetiologically linking glucose intolerance with coronary heart disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

et al. 1990

View full text Add to dashboard Cite

show abstract

“…arlson and Bottiger, 1985 29 Cambien et al, 1986 30 Meade et al, 1986 31 Barrett-Conner and Khaw, 1987 19 Criqui et al (in press) 32 total cholesterol; LDL-C, low density lipoprotein cholesterol; HDL-C, high density CVD, cardiovascular disease; CHD, coronary heart disease; IHD, ischemic heart disease.…”

Section: Studies In Subjects With Normal Cholesterol Levelsmentioning

confidence: 99%

“…45 -23 In the Paris Prospective Study, 30 initial multivariate analyses showed a significant interaction term between TC and triglyceride in relation to CHD death using Cox survival analysis. More detailed examination of the data revealed that when the study sample was divided into two groups, triglyceride showed a significant association with CHD among those subjects with TC less than or equal to 220 mg/dl (relative risk=1.8, p<0.05) and nonsignificant association among subjects with TC greater than 220 mg/dl.…”

Section: Studies In Subjects With Normal Cholesterol Levelsmentioning

confidence: 99%

Plasma triglyceride and coronary heart disease.

Austin

1991

Arterioscler Thromb

599

View full text Add to dashboard Cite

Although the literature on epidemiological associations between plasma triglyceride and CHD is not completely consistent, trends do emerge from the studies described here. First, the majority of observational studies demonstrate a significant univariate relation, although the results of case-control and cross-sectional studies are more uniform than those from prospective study designs. In many but not all studies, triglyceride remains a significant predictor of CHD in multivariate statistical analyses after controlling for TC or LDL-C. Perhaps the least consistent result is that the triglyceride association does not persist in some analyses controlling for HDL-C, while in other studies, the association remains significant. Although most studies have been conducted in men, the studies providing data on women, normocholesterolemic subjects, and diabetic subjects have generally found triglyceride to be, at the very least, a univariate risk factor. The results of intervention trials differ considerably, but no such study to date has been specifically designed to evaluate triglyceride-lowering effects on primary prevention of CHD. Important statistical properties must be taken into consideration in evaluating triglyceride as a risk factor for CHD. The large variability of triglyceride measurements and the correlation of triglyceride values with other lipid measures appears to result in the underestimation of the association between triglyceride and disease in multivariate analyses. Finally, individual genetic susceptibility may play an important role in the relation between plasma triglyceride levels and CHD. For example, risk of CHD clearly varies among the well-established familial forms of hypertriglyceridemia. A predominance of small, dense, LDL particles (LDL subclass pattern B) also appears to be a genetic trait associated with both increased risk of MI and increases in plasma triglyceride levels.

show abstract

“…Although a high level of serum cholesterol has been identified as a risk factor for atherosclerosis and coronary heart disease (Kanel et al, 1971), the role of a high level of triglycerides has only recently established as an independent risk factor for such diseases (Cambien et al, 1986;Austin, 1989). The medicinal properties of plants have been investigated in the light of recent scientific developments throughout the world, due to their potent pharmacological activities, low toxicity and economic viability (Sharma et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

Hypotriglyceridemic effect of Morus alba L., Moraceae, leaves in hyperlipidemic rats

Zeni¹,

Dall'Molin²

2010

Rev. bras. farmacogn.

View full text Add to dashboard Cite

RESUMO: "Efeito hipotrigliceridêmico de folhas de Morus alba L., Moraceae, em ratos hiperlipidêmicos". As folhas de amoreira branca Morus alba L., Moraceae, são utilizadas no Brasil na medicina popular para tratar febre, como protetor do fígado, para baixar a pressão e o colesterol. O extrato aquoso de folhas de M. alba foi administrado via oral através de gavagem em ratos hiperlipidêmicos com uma dieta enriquecida com colesterol (1%) com uma dose de 150 mg/kg/dia por quatorze dias que reduziu significativamente em 55,01% o nível de triglicerídios plasmáticos. Desta forma, o tratamento diminuiu o nível de triglicerídios e uma enzima hepática testada, demonstrando que extratos de Morus alba que tem sido popularmente utilizados possuem um grande potencial para se tornar um fitomedicamento. Unitermos: Morus alba, ratos hiperlipidêmicos, triglicerídios.ABSTRACT: Mulberry Morus alba L., Moraceae, leaves are used in Brazil medicines against fever, to protect the liver, to lower the blood pressure and cholesterol. The aqueous extract of leaves of M. alba given by oral route to hyperlipidemic rats with diet enriched by cholesterol (1% by weight) with dose of 150 mg/kg/day for forteen days reduced significantly by 55,01% the plasma triglycerides level. Therefore, the treatment not only decreased the plasma level of triglycerides but also affected a hepatic enzyme tested supportting the fact that the extracts of Morus alba that have been used by folk medicine have a great potential to be further developed into a phytomedicine.

show abstract

Is the Level of Serum Triglyceride a Significant Predictor of Coronary Death in “Normocholesterolemic” Subjects?

Cited by 157 publications

References 0 publications

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

Association of plasma triglyceride and C-peptide with coronary heart disease in Japanese-American men with a high prevalence of glucose intolerance

Plasma triglyceride and coronary heart disease.

Hypotriglyceridemic effect of Morus alba L., Moraceae, leaves in hyperlipidemic rats

Contact Info

Product

Resources

About