Is the LENT Score Already Outdated?

Rozman, Aleš; Mok, Tony

doi:10.1159/000491678

Cited by 3 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute renal failure (ARF) resulting from pericardial effusions with and without tamponade has been described in case reports and retrospective analyses. [8][9][10][11][12][13]19 In each of these studies, ARF was completely reversed after pericardial drainage. Several mechanisms have been suggested to explain the pathophysiology of AKI in this setting.…”

Section: Discussionmentioning

confidence: 90%

“…Acute renal failure (ARF) resulting from pericardial effusions with and without tamponade has been described in case reports and retrospective analyses 8–13,19 . In each of these studies, ARF was completely reversed after pericardial drainage.…”

Section: Discussionmentioning

confidence: 99%

“…Previous case studies have reported reversal of renal failure caused by pericardial effusion after treatment with pericardiocentesis 8–13 . In this study, we assessed the relationship between pericardiocentesis and resolution of pre‐procedural low cardiac output and acute renal dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“…7 Previous case studies have reported reversal of renal failure caused by pericardial effusion after treatment with pericardiocentesis. [8][9][10][11][12][13] In this study, we assessed the relationship between pericardiocentesis and resolution of pre-procedural low cardiac output and acute renal dysfunction. To our knowledge, this is the largest study examining the effect of pericardiocentesis on cardiac hemodynamics and renal function.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Effects of pericardiocentesis on renal function and cardiac hemodynamics

Shmueli,

Shah,

Patel

et al. 2024

Echocardiography

View full text Add to dashboard Cite

BackgroundPrevious case studies have reported reversal of acute renal failure after pericardiocentesis in pericardial effusion. This study examines the effects of pericardiocentesis on preprocedural low cardiac output and acute renal dysfunction in patients with pericardial effusion.MethodsThis is a retrospective study of 95 patients undergoing pericardiocentesis between 2015 and 2020. Pre‐ and post‐procedure transthoracic echocardiograms (TTE) were reviewed for evidence of cardiac tamponade, resolution of pericardial effusion, and for estimation of right atrial (RA) pressure and cardiac output. Laboratory values were compared at presentation and post‐procedure. Patients on active renal replacement therapy were excluded.ResultsNinety‐five patients were included for analysis (mean age 62.2 ± 17.8 years, 58% male). There was a significant increase in glomerular filtration rate pre‐ and post‐procedure. Fifty‐six patients (58.9%) had an improvement in glomerular filtration rate after pericardiocentesis (termed “responders”), and these patients had a lower pre‐procedure glomerular filtration rate than “non‐responders.” There was a significant improvement in estimated cardiac output and right atrial pressure for patients in both groups. Patients who had an improvement in renal function had significantly lower pre‐procedural diastolic blood pressure and mean arterial pressure.ConclusionsPericardial drainage may improve effusion‐mediated acute renal dysfunction by reducing right atrial pressure and thus systemic venous congestion, and by increasing forward stroke volume and perfusion pressure.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Effects of pericardiocentesis on renal function and cardiac hemodynamics

Shmueli,

Shah,

Patel

et al. 2024

Echocardiography

View full text Add to dashboard Cite

show abstract

“…Our study also confirms its effectiveness that LENT score shows an excellent prognostic value for malignant patients with pleural effusion, so do the LENT score calculation items (LDH, ECOG PS, NLR and tumor type). However, the LENT score has not included many important developments in the prognosis of pleural effusion [ 18 ]. In our study, positive EGFR mutation patients shows a better survival both in OS and PFS.…”

Section: Discussionmentioning

confidence: 99%

Prognostic biomarkers of malignant patients with pleural effusion: a systematic review and meta-analysis

Peng

Yang

et al. 2022

Cancer Cell Int

View full text Add to dashboard Cite

Background Pleural effusion is a common clinical problem in patients with cancer. We aimed to summarize all the known prognostic indicators of malignant pleural effusion. Methods We did a systematic review and meta-analysis with a systematic literature search. All prospective or retrospective cohort studies that estimated the prognostic factors of malignant pleural effusion were enrolled. Mantel–Haenszel method was used to calculate the pooled hazard ratio (HR) and 95% confidence interval (CI). Results Eventually, we identified 82 studies with a total of 10,748 patients that met our inclusion criteria. The LENT score showed a good prognostic value (HR 1.97, 95% CI 1.67–2.31) so did the LENT score item. In addition, clinical parameters like stage (HR 1.68, 95% CI 1.25–2.25), distant metastasis (HR 1.62, 95% CI 1.38–1.89), EGFR mutation (HR 0.65, 95% CI 0.56–0.74), serum biological parameters like hemoglobin (HR 1.56, 95% CI 1.17–2.06), albumin (HR 1.71, 95% CI 1.25–2.34), C-reaction protein (HR 1.84, 95% CI 1.49–2.29), VEGF (HR 1.70, 95% CI 1.18–2.43) and pleural effusion biological parameters like PH (HR 1.95, 95% CI 1.46–2.60), glucose (HR 1.75, 95% CI 1.18–2.61), VEGF (HR 1.99, 95% CI 1.67–2.37), and survivin (HR 2.90, 95% CI 1.17–7.20) are also prognostic factors for malignant pleural effusion. Conclusions For malignant pleural effusion, LENT score and its items are valuable prognostic biomarkers, so do the clinical parameters like stage, distant metastasis, EGFR mutation, the serum biological parameters like hemoglobin, albumin, C-reaction protein, VEGF and the pleural effusion biological parameters like PH, glucose, VEGF and survivin.

show abstract