Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Dalgas, Ulrik; Langeskov‐Christensen, Martin; Skjerbæk, Anders Guldhammer; Jensen, Ellen; Baert, Ilse; Romberg, Anders; Santoyo-Medina, Carme; Gebara, Benoit; Noordhout, B. Maertens de; Knuts, Kathy; Béthoux, François; Řasová, Kamila; Severijns, Deborah; Bibby, Bo Martin; Kalron, Alon; Norman, B. B.; Geel, Fanny Van; Wens, Inez; Feys, Peter

doi:10.1016/j.jns.2018.02.026

Cited by 28 publications

(22 citation statements)

References 44 publications

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“…It is the main neurological cause of functional disability in young adults (i.e., between 20 and 49 years old) [1,2]. It results in multiple neurological deficienciessensorimotor, balance, cognitive deficits, and fatigue-with a major impact on walking in persons with MS (PwMS) [3]. Moreover, in more than two-thirds of PwMS, a walking disorder is the most reported limiting activity [4] and contributes negatively towards PwMS's participation in their daily activities [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Prolonged Walking in Persons with Multiple Sclerosis: Reliability of the Spatio-Temporal Walking Variables during the 6-Minute Walk Test

Hadouiri

Monnet

Gouelle³

et al. 2021

Sensors

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Background: Walking disorders represent the most disabling condition in persons with Multiple Sclerosis (PwMS). Several studies showed good reliability of the 6-min walk test (6MWT) (i.e., especially distance traveled), but little is known about the reliability of the Spatio-temporal (ST) variables in the 6MWT. Objective: To evaluate the test-retest reliability of ST variables and perceived exertion during the 6MWT in PwMS and comparable healthy persons. Methods: We explored three 1-min intervals (initial: 0′–1′, middle: 2′30″–3′30″, end: 5′–6′) of the 6MWT. Six ST variables and perceived exertion were measured (respectively, using the GAITRite system and the Borg Scale). These measurements were performed twice, 1 week apart. The test-retest effects were assessed using the intraclass correlation coefficient (ICC) or the weighted kappa. Results: Forty-five PwMS and 24 healthy persons were included. The test-retest reliability of ST variables values was good-to-excellent for PwMS (ICC range: 0.858–0.919) and moderate-to-excellent for healthy persons (ICC range: 0.569–0.946). The test-retest reliability values of perceived exertion were fair for PwMS (weighted kappa range: 0.279–0.376) and substantial for healthy persons (weighted kappa range: 0.734–0.788). Conclusion: The measurement of ST variables during these 6MWT intervals is reliable and applicable in clinical practice and research to adapt rehabilitation care in PwMS.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Prolonged Walking in Persons with Multiple Sclerosis: Reliability of the Spatio-Temporal Walking Variables during the 6-Minute Walk Test

Hadouiri

Monnet

Gouelle³

et al. 2021

Sensors

View full text Add to dashboard Cite

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“…2 The association between walking impairment on the one hand and perceived fatigue on the other stresses the importance of maintaining walking ability. 3,4 On the longer term, gait impairment can lead to a decreased physical fitness and increased risk for comorbidities such as depression and cardiovascular impairments in addition to the severity of MS. 5,6 A common parameter characterizing gait impairment in neurological disorders is a decreased self-selected (comfortable) walking speed. In pwMS, gait is affected by increased muscle tone, 7 impaired sensation and coordination, 8 and can further be negatively influenced by disease symptoms such as muscle weakness, 9 pain, and fatigue.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Walking Speed and the Energetic Cost of Walking in Persons With Multiple Sclerosis and Healthy Controls: A Systematic Review

Theunissen

Plasqui

Boonen

et al. 2021

Neurorehabil Neural Repair

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Background Persons with multiple sclerosis (pwMS) experience walking impairments, characterized by decreased walking speeds. In healthy subjects, the self-selected walking speed is the energetically most optimal. In pwMS, the energetically most optimal walking speed remains underexposed. Therefore, this review aimed to determine the relationship between walking speed and energetic cost of walking (Cw) in pwMS, compared with healthy subjects, thereby assessing the walking speed with the lowest energetic cost. As it is unclear whether the Cw in pwMS differs between overground and treadmill walking, as reported in healthy subjects, a second review aim was to compare both conditions. Method PubMed and Web of Science were systematically searched. Studies assessing pwMS, reporting walking speed (converted to meters per second), and reporting oxygen consumption were included. Study quality was assessed with a modified National Heart, Lung and Blood Institute checklist. The relationship between Cw and walking speed was calculated with a second-order polynomial function and compared between groups and conditions. Results Twenty-nine studies were included (n = 1535 pwMS) of which 8 included healthy subjects (n = 179 healthy subjects). PwMS showed a similar energetically most optimal walking speed of 1.44 m/s with a Cw of 0.16, compared with 0.14 mL O2/kg/m in healthy subjects. The most optimal walking speed in treadmill was 1.48 m/s, compared with 1.28 m/s in overground walking with a similar Cw. Conclusion Overall, the Cw is elevated in pwMS but with a similar energetically most optimal walking speed, compared with healthy subjects. Treadmill walking showed a similar most optimal Cw but a higher speed, compared with overground walking.

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“…3–5,31 Focusing on motor fatigue , Sehle and colleagues 37,38 show a significant correlation between subject-reported fatigue (while walking on a treadmill) and changes in gait. The complexity of investigating self-report measures and walking task performance is further discussed in Dalgas et al 39 while reporting significant correlations between walking ability and scores on the self-report MFIS.…”

Section: Renaming Ms Daily Onset Symptomologymentioning

confidence: 99%

What’s in a name? That which we call Multiple Sclerosis Fatigue

2020

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Very limited progress has been made to date in the treatment of debilitating Multiple Sclerosis (MS) daily onset symptoms. These daily symptoms include motor, sensory, and cognitive impairments as well as an overwhelming feeling of tiredness, often referred to as “MS fatigue.” Although widely cited as a main cause of inability to work and poor quality of life in patients with MS, daily onset MS-related tiredness continues to defy definition, and, consequently, measurement and treatment. Beginning with a historical overview of observations of daily onset MS-related tiredness, this Topical Review demonstrates how the misnomer “MS fatigue” has introduced ongoing misunderstanding for patients, investigators, clinicians, and therapists. Finally, combining current findings in clinical neuroscience with the striking set of long-standing commonalities present throughout the past 200 years of clinical observations, we underscore the immediate necessity for conceptual and applied change, to be initiated by the renaming of this distinct syndrome.

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Is the impact of fatigue related to walking capacity and perceived ability in persons with multiple sclerosis? A multicenter study

Cited by 28 publications

References 44 publications

Evaluation of Prolonged Walking in Persons with Multiple Sclerosis: Reliability of the Spatio-Temporal Walking Variables during the 6-Minute Walk Test

Evaluation of Prolonged Walking in Persons with Multiple Sclerosis: Reliability of the Spatio-Temporal Walking Variables during the 6-Minute Walk Test

The Relationship Between Walking Speed and the Energetic Cost of Walking in Persons With Multiple Sclerosis and Healthy Controls: A Systematic Review

What’s in a name? That which we call Multiple Sclerosis Fatigue

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