Is the HPV virus responsible for the development of breast cancer?

Kúdela, Erik; Ňachajová, Marcela; Danko, Ján

doi:10.1111/tbj.13399

Cited by 4 publications

(4 citation statements)

References 7 publications

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“…Viruses such as human papillomavirus (HPV), epstein-barr virus (EBV), mouse mammary tumor virus (MMTV), and bovine leukemia virus (BLV) show potential roles in breast cancer development, but the epidemiological and proposed oncogenic mechanisms have not yet provided strong conclusive evidence [ 4 , 5 ]. The main step in the development of malignant change is the integration of HPV infection into the genetic makeup of epithelial cells [ 6 ]. There is considerable debate and skepticism about the notion that HPV infection is the etiological factor contributing to the development of breast cancer [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…The main step in the development of malignant change is the integration of HPV infection into the genetic makeup of epithelial cells [6]. There is considerable debate and skepticism about the notion that HPV infection is the etiological factor contributing to the development of breast cancer [6]. The presence of HPV in malignant breast tumors has been reported, indicating a potential role of HPV in the early stage of breast cancer and breast carcinogenesis [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…It allows for the simultaneous amplification, detection, and separation of target nucleic acids from 19 high-risk HPV types(16,18, 26,31,33,35,39,45, 51, 52, 53, 56, 58, 59, 66, 68, 69, 73, 82) and 9 low-risk HPV types(6,11,40,42,43,44, 54, 61, 70) as well as an internal control (IC). The human housekeeping gene (human beta-globin) was used as an endogenous IC to ensure extraction of DNA, verification of PCR reaction, and clarification of cell adequacy from each specimen.…”

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confidence: 99%

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High rate of high-risk human papillomavirus among benign and breast cancer patients in Ethiopia

Belachew,

Desta,

Mulu

et al. 2024

PLoS ONE

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Introduction There have been numerous studies that showed the presence of human papillomavirus (HPV) in breast cancer; nonetheless, there is ongoing debate regarding their association. Given few studies in Ethiopia, we aimed to investigate the magnitude of HPV infection in Ethiopian breast cancer patients. Methods A total of 120 formalin-fixed paraffin-embedded (FFPE) tissue blocks were obtained, and basic demographic, clinical, and histological data were collected from medical records. DNA was extracted from archived FFPE breast tissue specimens using GeneRead DNA FFPE Kit. The AnyplexTM II HPV28 Detection Kit (Seegene, Korea) was used to detect HPV by following the manufacturer’s instructions. The SPSS Version 25 was used to enter and analyze data. Results Among the 120 study participants; HPV (both high-risk and low-risk) was detected in 20.6% of breast cancer and 29.6% of non-malignant breast tumors. The most common genotype was the high-risk HPV 16 genotype. The frequency of HPV was nearly 10-fold higher in estrogen receptor-positive than ER-negative breast cancer. The percentage of HPV in the luminal (luminal A and luminal B) breast cancer subtypes was also much higher than in the non-luminal subtypes (HER-2 enriched and triple-negative breast cancer). Conclusion This study did not find a significant difference in HPV expression between breast cancer and non-malignant breast tumors; however, the higher percentage of HPV in ER-positive compared to ER-negative breast cancer warrants further attention.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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High rate of high-risk human papillomavirus among benign and breast cancer patients in Ethiopia

Belachew,

Desta,

Mulu

et al. 2024

PLoS ONE

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“…[ 4 ] Moreover, the latest meta-analysis between this association showed an increased risk of breast cancer in HPV DNA-positive individuals. [ 5 ]…”

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confidence: 99%