Is the gut microbiota associated with suicidality? Non-significant finding among a large cohort of psychiatrically hospitalized individuals with serious mental illness

Thompson, Debbe; Fowler, J. Christopher; Bradshaw, Major; Frueh, B. Christopher; Weinstein, Benjamin; Petrosino, Joseph F.; Hadden, Julia K.; Madan, Alok

doi:10.1016/j.jadr.2021.100266

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Five out of six studies reported a significant association of suicidal behavior with the microbiome [109][110][111][112][113]. One well-powered study investigating fecal swabs collected from 100 psychiatric inpatients did not find any significant relationship between gut microbiota composition and suiciderelated behavior [114]. However, only 35 individuals out of the included 100 exhibited past suicidal behavior, which significantly dilutes the interpretation of the result.…”

Section: Microbiome and Suicidal Behaviormentioning

confidence: 96%

“…Five studies demonstrated an association between changes in the microbiome and suicidal behavior. Only Thompson and Fowler [114] reported no significant relationship between gut microbiota composition and "suicidality" in a cohort of mentally ill people. In this study, stool specimens of a large sample of 100 people with and without suicidal thoughts and behavior were analyzed, forming a homogeneous sample in terms of medication status.…”

Section: Microbiomementioning

confidence: 98%

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Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Zerekidze,

Li,

Refisch

et al. 2024

JCM

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Background: Suicide remains a persistent global health challenge, resisting widespread prevention efforts. According to previous findings, toxoplasmosis is particularly associated with altered decision making, which could lead to risk-taking behavior, thereby increasing the likelihood for suicidal behavior (SB). In addition, discussion about the role of microbiome in psychiatric disorders has emerged lately, which also makes it relevant to investigate its role in the context of SB. Therefore, two systematic reviews are integrated in this paper, and the existing knowledge is comprehensively summarized regarding the association between microbial pathogens and SB. Methods: We conducted a systematic search with keywords including SB and Toxoplasma gondii (Suicid* AND Toxoplasm*) and microbiome (Suicid* AND Microbiome AND Microbiota) throughout PubMed and Scopus to retrieve related studies up to 9 November 2023, identifying 24 eligible records. The subjects of the included studies had to have fulfilled the criteria of an SB disorder as defined by DSM-5, and death cases needed to have been defined as suicide. Results: Most studies reported significant association between toxoplasmosis and SB, suggesting a higher likelihood of SB in the infected population. Regarding the microbiome, only very few studies investigated an association between SB and alterations in the microbiome. Based on six included studies, there were some indications of a link between changes in the microbiome and SB. Conclusion: The cognitive aspects of decision making in T. gondii-infected individuals with SB should be further investigated to unravel the underlying mechanisms. Further sufficiently powered studies are needed to establish a link between SB and alterations in the microbiome.

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Section: Microbiome and Suicidal Behaviormentioning

confidence: 96%

Section: Microbiomementioning

confidence: 98%

Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Zerekidze,

Li,

Refisch

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

Impact of Microbial Pathogens on Suicidal Behavior: A Systematic Review

Zerekidze,

Li,

Refisch

et al. 2023

Preprint

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Suicide remains a persistent global health challenge, resisting widespread prevention efforts. According to previous findings, toxoplasmosis is particularly associated with altered deci-sion-making, which could lead to risk-taking behavior thereby increasing the likelihood for sui-cidal behavior (SB). In addition, discussion about the role of microbiome in psychiatric disorders has emerged lately, which also makes it relevant to investigate its role in the context of SB. Therefore, the current review aimed to comprehensively summarize existing knowledge regard-ing the association between microbial pathogens and SB. We conducted a systematic search with keywords including suicide and Toxoplasma gondii (Suicid* AND Toxoplasm*) and microbiome (Microbiome AND Suicid*) throughout PubMed to retrieve the related studies up to 09.11.2023. Most results reported significant association between toxoplasmosis and SB, suggesting a higher likelihood of SB in the infected population. Regarding the microbiome, only very few studies in-vestigated an association between SB and alterations in microbiota. Based on those few studies, changes in the microbiome were significantly associated with SB. The cognitive aspects of deci-sion-making in T. gondii infected individuals with SB should be further investigated to unravel underlying mechanisms. Further sufficiently powered studies are needed to establish a link be-tween SB and gut microbiota.

show abstract

Is the gut microbiota associated with suicidality? Non-significant finding among a large cohort of psychiatrically hospitalized individuals with serious mental illness

Cited by 2 publications

References 46 publications

Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Impact of Microbial Pathogens on Suicidal Behavior: A Systematic Review

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