Is the diagnosis and treatment of childhood acute bacterial meningitis in Turkey evidence-based?

IntroductionCentral nervous system (CNS) infections are life-threatening diseases caused by viral, bacterial, parasitic and fungal microorganisms. The aim of this study was to determine the accuracy of universal polymerase chain reaction (PCR) for the detection of bacterial meningitis among patients who were referred to Koodakan Hospital in Bandar Abbas because they were suspected of having the disease.MethodsThis study was conducted in 2013 on the patients who were admitted to Bandar Abbas’ Koodakan Hospital because they were suspected of having meningitis. A questionnaire, including demographic data, was completed for each patient. Universal PCR, Cerebrospinal fluid (CSF) analysis, and gram staining and cultures were done for all the patients. The data were analyzed using SPSS software.ResultsAmong the 100 patients studied 59 (59%) were male and 41 (41%) were female. No patient in our study had a positive smear and culture for meningitis. Among the patients with negative smears and cultures six (6%) had positive universal PCR, and 94 (94%) had negative universal PCR. Based on these results, PCR had 95% specificity and 100% negative predictive value for the prediction of meningitis. In 30 patients (30%), the biochemical analysis of CSF were in favor of meningitis. Among the 30 patients, six patients (20%) had positive universal PCR and 24 patients (80%) had negative universal PCR.ConclusionBased on our results, the universal PCR test is useful in the diagnosis of bacterial meningitis in children. We recommend using it in combination with other tests, such as CSF analysis, for diagnosis of bacterial meningitis.

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Accuracy of universal polymerase chain reaction (PCR) for detection of bacterial meningitis among suspected patients

Moayedi

Nejatizadeh

Mohammadian

et al. 2015

Electron physician

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Is the diagnosis and treatment of childhood acute bacterial meningitis in Turkey evidence-based?

Abstract: We reviewed the records of children of 1 month to 5 years of age who were admitted to 11 tertiary hospitals in İstanbul with a diagnosis of ABM during 2005. The study centers included 2 university hospitals (

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Accuracy of universal polymerase chain reaction (PCR) for detection of bacterial meningitis among suspected patients

Accuracy of universal polymerase chain reaction (PCR) for detection of bacterial meningitis among suspected patients

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