Is the choice of vaccine adjuvant critical for long-term memory development?

Lycke, Nils

doi:10.1586/erv.10.136

Cited by 9 publications

(7 citation statements)

References 58 publications

(58 reference statements)

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“…Influenza infection is known to induce a Th1 skewed response while influenza subunit vaccines are associated with a Th2 response [59]. Several other adjuvants have also been shown to induce Th2 responses when administered mucosally, including immunostimulating complexes (ISCOMs) [60], cholera toxin (CT) [61] and Escherichia coli heat labile enterotoxin (LT) [62, 63]. Protection against influenza A is suggested to benefit from a predominately Th1 or a balanced Th response [59].…”

Section: Discussionmentioning

confidence: 99%

Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually

Spinner¹,

Oberoi²,

Yorgensen³

et al. 2015

Vaccine

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Influenza is a vaccine-preventable contagious respiratory illness caused by influenza (flu) viruses which can lead to hospitalization and sometimes even death. Current flu vaccines delivered intramuscularly (IM) or intradermally (ID) are less effective at eliciting protective mucosal immune responses and vaccines delivered intranasally (IN) possess potential safety concerns. Sublingual (SL) vaccination is a promising alternative route for vaccine delivery which has been indicated as safe and effective at inducing protective immune responses in both systemic and mucosal compartments. We evaluated the efficacy of methylglycol chitosan (MGC) and a synthetic toll-like receptor 4 agonist (CRX-601), alone or in combination, for improving systemic and mucosal immune responses to a monovalent detergent-split flu virus vaccine delivered SL. SL vaccination of mice with split-flu vaccine formulated with either MGC or CRX-601 resulted in specific serum IgG and mucosal IgA titers that were significantly greater than titers from non-adjuvanted vaccination and equivalent to or greater than titers in mice vaccinated IM. Our results demonstrate that SL vaccination utilizing MGC or CRX-601 as adjuvants is a viable alternative route of vaccination for flu which can elicit systemic immune responses equivalent to or greater than IM vaccination with the added benefit of stimulating a robust specific mucosal immune response.

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Section: Discussionmentioning

confidence: 99%

Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually

Spinner¹,

Oberoi²,

Yorgensen³

et al. 2015

Vaccine

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show abstract

“…A palavra adjuvante deriva do latin "adjuvare" e significa "ajudar", sendo o termo adjuvante designado a qualquer composto capaz de aumentar a imonogenicidade intrínsica de um antígeno co-administrado ou modular a resposta imunológica naturalmente induzida contra o antígeno (KRIEG, 2007;LYCKE, 2010).…”

Section: )unclassified

Pesquisa de novos adjuvantes para vacinas terapêuticas.

Braga¹

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“…A palavra adjuvante vem do latim "adjuvare" cujo significado é ajudar. Adjuvantes são substâncias que, quando adicionadas a vacinas, aumentam a eficiência da resposta imune (Lycke, 2010).…”

Section: Adjuvantesunclassified

“…Os adjuvantes podem possibilitar o uso de menor quantidade de antígeno, propiciando o aumento de doses produzidas e a potencialização da resposta imune gerada pela vacina com a qual está sendo formulado. A potencialização pode estar relacionada com a liberação vagarosa do antígeno e o aumento da captação pelas APCs, propiciando o aumento de sua entrega aos linfócitos T para a ativação da resposta imune adaptativa (Lycke, 2010).…”

Section: Adjuvantesunclassified

Caracterização da resposta imunológica induzida por vacinas da Influenza produzidas no Instituto Butantan formuladas com adjuvantes.

Rico¹

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Is the choice of vaccine adjuvant critical for long-term memory development?

Cited by 9 publications

References 58 publications

Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually

Methylglycol chitosan and a synthetic TLR4 agonist enhance immune responses to influenza vaccine administered sublingually

Pesquisa de novos adjuvantes para vacinas terapêuticas.

Caracterização da resposta imunológica induzida por vacinas da Influenza produzidas no Instituto Butantan formuladas com adjuvantes.

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