Is the autophagy a friend or foe in the silver nanoparticles associated radiotherapy for glioma？

Wu, Hao; Lin, Jun; Liu, Peidang; Huang, Zhihai; Zhao, Peng; Jin, Haizhen; Wang, Cailian; Wen, Longping; Gu, Ning

doi:10.1016/j.biomaterials.2015.05.033

Cited by 66 publications

(72 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the ejected photoelectrons, the as-formed vacancies in atoms will be filled with electrons from higher orbits. [82][83][84] Pt nanoparticles [85,86] Ag nanoparticles; Fe 3 O 4/ Ag nanocomposite [87][88][89][90][91] Non high-Z elements Iron oxide nanoparticles [92][93][94] TiO 2 nanoparticles/nanotubes [95,96] Si nanoparticles [97,98] www.advmat.de www.advancedsciencenews.com (1.9 nm) -loaded polymeric micelles that exhibited longer blood circulation and 6-fold increase in tumor uptake, compared to that of ultrasmall Au nanoparticles (1.9 nm). Thus, in order to take advantage of such Auger effect, the exited atoms must be close enough to target molecules.…”

Section: Mechanisms Of Radio-sensitization With High-z Elementsmentioning

confidence: 99%

“…Silver nanoparticles (Z = 47) have been investigated as [83] Copyright 2016, Elsevier. [87,117,118,121,122] For instance, it was reported that chitosan-coated Ag triangular nanoparticles exhibited better radio-sensitizing activity on human nonsmall lung cancer cells than that of PEG coated Au nanoparticles. [87,117,118,121,122] For instance, it was reported that chitosan-coated Ag triangular nanoparticles exhibited better radio-sensitizing activity on human nonsmall lung cancer cells than that of PEG coated Au nanoparticles.…”

Section: Nanoparticles For Radio-sensitization With Other Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

View full text Add to dashboard Cite

Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

show abstract

Section: Mechanisms Of Radio-sensitization With High-z Elementsmentioning

confidence: 99%

Section: Nanoparticles For Radio-sensitization With Other Mechanismsmentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…51 Contrary to the role of autophagy triggered by most nanomaterials, our recently reported studies have revealed that autophagy initiated by AgNPs or/and radiation mediates cytoprotective effect, which is believed to serve as a pro-survival process of cells facing AgNPs and their associated radiation. 49,52 Given that both AuNPs and AgNPs belong to the noble metal nanoparticles, and the roles of their enhanced autophagy are the same, 49,53 this could indicate that autophagy activated by AuNPs plus radiation may be similar in function to that by AgNPs plus radiation. Since protective autophagy antagonizes apoptotic cell death induced by cancer chemotherapy and radiation therapy, 54,55 pharmacological inhibition of this type of autophagy should enhance the anticancer activity of AuNPs alone, AgNPs alone, or their combination with radiation, in particular that of AgNPs-based treatment.…”

Section: Promotion Of Autophagy By Aunps or Agnps In Combination Withmentioning

confidence: 99%

Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma

Liu¹,

Jin²,

Guo³

et al. 2016

IJN

Self Cite

113

View full text Add to dashboard Cite

Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma.

show abstract

“…32 NDs enter the selective autophagy pathway and are delivered to lysosomes but do not increase free radical generation, cell death, or senescence. Several studies have shown no obvious cytotoxicity for NDs in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…31 Furthermore, nanoparticles can induce cellular protective autophagy. 32 Hence, delineating the precise mechanisms of autophagy pathways is crucial to facilitate the biomedical applications of nanomaterials.…”

mentioning

confidence: 99%

Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway

et al. 2017

View full text Add to dashboard Cite

Selective macroautophagy/autophagy plays a pivotal role in the processing of foreign pathogens and cellular components to maintain homeostasis in human cells. To date, numerous studies have demonstrated the uptake of nanoparticles by cells, but their intracellular processing through selective autophagy remains unclear. Here we show that carbon-based nanodiamonds (NDs) coated with ubiquitin (Ub) bind to autophagy receptors (SQSTM1 [sequestosome 1], OPTN [optineurin], and CALCOCO2/NDP52 [calcium binding and coiled-coil domain 2]) and are then linked to MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) for entry into the selective autophagy pathway. NDs are ultimately delivered to lysosomes. Ectopically expressed SQSTM1-green fluorescence protein (GFP) could bind to the Ub-coated NDs. By contrast, the Ub-associated domain mutant of SQSTM1 (DUBA)-GFP did not bind to the Ub-coated NDs. Chloroquine, an autophagy inhibitor, prevented the ND-containing autophagosomes from fusing with lysosomes. Furthermore, autophagy receptors OPTN and CALCOCO2/NDP52, involved in the processing of bacteria, were found to be involved in the selective autophagy of NDs. However, ND particles located in the lysosomes of cells did not induce mitotic blockage, senescence, or cell death. Single ND clusters in the lysosomes of cells were observed in the xenografted human lung tumors of nude mice. This study demonstrated for the first time that Ub-coated nanoparticles bind to autophagy receptors for entry into the selective autophagy pathway, facilitating their delivery to lysosomes.

show abstract

Is the autophagy a friend or foe in the silver nanoparticles associated radiotherapy for glioma？

Cited by 66 publications

References 72 publications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma

Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway

Contact Info

Product

Resources

About