Is the Association between Dietary Trans Fatty Acids and Insulin Resistance Remarkable in Japan?

Tsutsui, Wao; Fujioka, Yoshio

doi:10.5551/jat.ed080

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…The term TFA is referred to unsaturated fatty acids which have at least one trans arrangement of carbon atoms alongside the unconjugated double bond (5). TFAs have various adverse health impacts even up to ten times those of saturated fatty acids (SFAs) including increased low density lipoproteins, decreased high density lipoproteins and hence dramatic increased risk of cardiovascular diseases (CVDs), insulin resistance, obesity, and type-2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Is Trans Fatty Acid Still an Issue for Policy Makers in Iran? A Technical Report

et al. 2018

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A B S T R A C TIn recent decades, the oil industry has changed its direction toward vegetable oil use instead of animal fats due to various reasons such as a small numbers of animal fat resources and high saturated fatty acids content in animal fats. Therefore, different modification processes have been used to alter the physicochemical properties of vegetable oils, which lack functionality and oxidative stability in their native form. Hydrogenation process is a common way to produce plastic fats with different functionality in order to formulate different bakery fats, spreads and margarines. Unfortunately, formation of trans fatty acids (TFAs), which have several negative impacts on human health, is the consequence of this process. Therefore, international and national organizations have established legislations and policies to reduce or preferably eliminate TFAs from hydrogenated vegetable oils.The objective of this study is firstly to review international and national legislations as well as the current status of TFAs in food products in Iran and worldwide, to discuss the gaps. Secondly, the strategies to address these gaps will be proposed. Through this article we will show that despite great efforts having been made in Iran, there is still room to make the documented policies and their conformities with each other to minimize the amount of TFAs in food products much more efficient.

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Section: Introductionmentioning

confidence: 99%

Is Trans Fatty Acid Still an Issue for Policy Makers in Iran? A Technical Report

et al. 2018

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“…Therefore, the mechanisms underlying the relationship between elevated circulating elaidic acid and the incidence of TLR cannot be attributed to the lipid profile alone. Excessive TFA intake is also assumed to induce abnormal glucose metabolism 11,23,24 and elevated inflammatory biomarkers. 25,26 But while mean HbA1c increased in patients with higher elaidic acid, no significant difference was noted in elaidic acid quartiles.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan

Oshita

Toh

Shinohara

et al. 2019

Circ J

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Background: Trans-fatty acid (TFA) intake increases the risk of coronary artery disease (CAD). Our previous cross-sectional survey showed that middle-aged patients with CAD in Japan have elevated serum TFA. In this study, we longitudinally investigated whether elevated TFA is a risk factor in the secondary prevention of CAD for the same-age patients. Methods and Results: A total of 112 patients (age, 21-66 years) who underwent percutaneous coronary intervention were followed up for up to 2 years. Serum elaidic acid was measured using gas chromatography/mass spectrometry as a marker of TFA intake and divided into quartiles. The primary endpoint was ischemia-driven target lesion revascularization (TLR). The hazard ratio (HR) for TLR increased significantly with higher serum elaidic acid (P<0.01). The significant positive trend remained unchanged after adjusting for conventional lipid profile and bare-metal stent usage. In contrast, although triglycerides and low-density lipoprotein cholesterol were positively correlated with elaidic acid, they were not associated with TLR. On multivariable Cox proportional hazard analysis, elevated elaidic acid was independently associated with TLR risk after adjusting for conventional coronary risks (HR,

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Is the Association between Dietary Trans Fatty Acids and Insulin Resistance Remarkable in Japan?

Cited by 2 publications

References 12 publications

Is Trans Fatty Acid Still an Issue for Policy Makers in Iran? A Technical Report

Is Trans Fatty Acid Still an Issue for Policy Makers in Iran? A Technical Report

Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan

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