“…While the AT 1 receptor is distributed ubiquitously in the vasculature, kidney, adrenal gland, heart, liver and brain [25], the AT 2 receptor is only expressed in the adrenal medulla, uterus, ovary, vascular endothelium and distinct brain areas of adults [26]. The AT 2 receptor is upregulated in pathophysiologic conditions such as cardiac failure, myocardial infarct, cerebral ischemia, and skin and nervous system lesions [27,28,29,30]. …”