Is the Androgen Deficiency of Aging Men (ADAM) questionnaire useful for the screening of partial androgenic deficiency of aging men?

Blümel, Juan E.; Chedraui, Peter; Gili, Sebastian A.; Navarro, A.; Valenzuela, Karen; Vallejo, Soledad

doi:10.1016/j.maturitas.2009.04.004

Cited by 32 publications

(28 citation statements)

References 27 publications

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“…25 For instance, in five different clinical settings, the sensitivity of the ADAM in detecting low T was good (81%-97%), but the specificity was poor (19.7%-32%). [26][27][28][29][30] Similar figures were reported for the AMS and MMAS. 27 Moreover, 6 months of oral T supplementation had no significant effect on scores of the ADAM and AMS questionnaires in a group of elderly men with low-normal T levels.…”

Section: Structured Inventories For Detecting Lohsupporting

confidence: 77%

How to recognize late-onset hypogonadism in men with sexual dysfunction

Corona¹,

Rastrelli²,

Vignozzi³

et al. 2012

Asian J Androl

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Late-onset hypogonadism (LOH) has been considered the most common form of male hypogonadism with a prevalence of approximately 1 in 100 men. Diagnosis of LOH should be made in symptomatic men with unequivocally low serum testosterone (T) levels. However, its clinical presentation is often insidious and difficult to recognize because it is characterized by nonspecific symptoms that make differential diagnosis with physiological ageing problematic. Sexual dysfunction is the most important determinant for medical consultation and the most specific symptom associated with low T. We therefore analysed a consecutive series of 1734 subjects who attended our unit for sexual dysfunction to investigate the associations between low T (different thresholds), sexual parameters, medical history data (delayed puberty, pituitary disease or cryptorchidism) and their physical exam results. Metabolic parameters, in particular waist circumference, display the greatest accuracy in detecting low T. We found that only the association of several symptoms and signs could significantly raise the clinical suspicion of low T. Structured inventories, which cluster together symptoms and signs of hypogonadism, can help clinicians suspect androgen deficiency. In particular, structured interviews, such as ANDROTEST, have been demonstrated to have a greater accuracy when compared to self reported questionnaires in detecting low T levels. Keywords: late-onset hypogonadism (LOH); male hypogonadism; testosterone; sexual dysfunction INTRODUCTIONThe testis (the male gonad) continuously produces sex steroids (mostly testosterone (T)) and sperm soon after the onset of puberty. Testis activity is regulated by intratesticular factors (including T) and by extratesticular trophic factors released from the pituitary (i.e., gonadotropin luteinizing hormone (LH) and follicle-stimulating hormone (FSH)), which are strictly regulated by the hypothalamic peptide gonadotropin-releasing hormone (GnRH). Male hypogonadism is a failure in testis activity that is classically considered to be a partial or total communication breakdown among the hypothalamus, the pituitary and the testis itself. Current definitions of hypogonadism rely on T deficiency more than abnormal sperm production, but from a conceptual point of view, both factors contribute to testicular function and dysfunction.

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Section: Structured Inventories For Detecting Lohsupporting

confidence: 77%

How to recognize late-onset hypogonadism in men with sexual dysfunction

Corona¹,

Rastrelli²,

Vignozzi³

et al. 2012

Asian J Androl

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“…However, in our study, no significant association between total AMS scores and testosterone or SHBG levels were observed. Our results together with previous findings [13,14] suggest that the AMS scale may have a high degree of sensitivity to detect the presence of symptoms/signs of LOH but may be relatively poor in regard to specificity. This is because the detected symptoms/signs can be caused by factors other than testosterone deficiency.…”

Section: Discussionsupporting

confidence: 62%

“…The AMS questionnaire assists in both the diagnosis of testosterone deficiency and monitoring of patients using testosterone replacement therapy. However, numerous reports have determined that AMS values are not specific to the detection of testosterone deficiency [12][13][14][15][16]. Thus, it is unclear what conditions are reflected by AMS values.…”

Section: Evaluations Of Various Markersmentioning

confidence: 99%

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men

et al. 2017

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DECREASED ANDROGEN LEVELS associated with aging cause various symptoms, termed late-onset hypogonadism (LOH) [1][2][3]. LOH is characterized by (i) somatovegetative symptoms and conditions, including weakness, fatigue, sleep disturbance, visceral obesity, sarcopenia and osteopenia (or osteoporosis), (ii) psychological symptoms, including disturbed sense of well-being, depressed mood, irritability and anxiety and (iii) sexual symptoms, including decreased libido and erectile dysfunction.Visceral obesity has been proposed to be caused by vice circulation. Specifically, decreased androgen lev-A higher score on the Aging Males' Symptoms scale is associated with insulin resistance in middle-aged men Abstract. An age-associated androgen decrease and its pathological conditions are defined as late-onset hypogonadism (LOH). Among the various symptoms associated with LOH, a visceral fat increase is strongly associated with relatively low levels of testosterone. However, few studies have investigated the relationship between the Aging Males' Symptoms (AMS) scores and metabolic abnormalities. Thus, we aimed to clarify this relationship by investigating the relationship between AMS scores and various markers in blood. During routine health examinations in 241 middle-aged males (52.7±7.5 years of age, mean±SD), 150 males (62.2%) displayed higher AMS values than normal. No statistical association was observed between total AMS scores and any testosterone value. All mental, physical and sexual AMS subscales were significantly positively correlated with insulin levels and HOMA-IR. Only sexual subscale scores were significantly inversely associated with free or bioavailable testosterone level. Males with insulin resistance (HOMA-IR≥2.5) demonstrated significantly higher AMS scores than those with normal insulin sensitivity (HOMA-IR<2.5). AMS values were positively correlated with fasting blood glucose, insulin and HOMA-IR values. Interestingly, univariate and multivariate analyses revealed that HOMA-IR≥2.5 was a significant predictor for detection of moderately severe AMS values (AMS≥37), whereas AMS≥37 was not a predictor of metabolic syndrome by International Diabetes Federation (IDF) criterion. In conclusion, almost 60% of healthy male subjects displayed abnormal AMS scores. AMS values were not associated with testosterone values but rather were related to insulin resistance, particularly in subjects with moderately severe AMS values. Insulin resistance-related general unwellness might be reflected by AMS values.Key words: Testosterone, Late-onset hypogonadism, Insulin resistance, Metabolic syndrome els result in visceral obesity, which then leads to the suppression of gonadotropin and subsequent testosterone deficiency [4]. We have reported that male ARKO mice develop visceral obesity because of decreased energy expenditure [5]. Metabolic syndrome (MetS) is characterized by multiple cardiovascular risk complications, including visceral obesity, hypertension, glucose tolerance and dyslipidemia. MetS incidence is rapidly incre...

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“…In a study by Araujo et al 4.2% of men younger than 50 YY were diagnosed with symptomatic androgen deficiency and 8.4% of men 50+ YY [26]. Men were considered symptomatic if they had one of the specific sexual symptoms (low libido, erectile dysfunction, or osteoporosis) or two or more of the nonspecific symptoms (sleep disturbance, depressed mood, lethargy, or low physical performance), in line with guidelines that are proposed by The Endocrine Society [27]. In our questionnaire, only one of these three symptoms was asked for; erectile dysfunction; however in a milder form expressed by the phrase "less strong erections" as used in the ADAMquestionnaire.…”

Section: Discussionmentioning

confidence: 93%

Symptoms of testosterone deficiency in early middle aged men

Holm¹,

Fredrikson²,

Hammar³

2012

The Aging Male

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Symptoms of testosterone deficiency and concentrations of testosterone (T) and bioavailable testosterone (BT) were studied in 35-and 45-year-old men. Methods: A questionnaire, was sent to all 35-and 45-year-old men in Linkoping, Sweden (n = 1998). The questionnaire has earlier been used for 55- to 75-year-old men and included demographic data, medical history, different symptoms possibly of T deficiency and the 10 questions from the "ADAM-questionnaire". Totally 200 men randomly selected among the men who answered the questionnaire were asked to give blood samples for analysis of T-and BT-concentrations. Results: A total of 38.7% of the questionnaires were returned and analysed, and 43.5% of the 200 randomly selected men gave blood samples. The older age group reported more symptoms that may be connected to low B and BT and had lower T-and BT-concentrations. Less strong erections and higher alcohol consumption were associated with lower concentrations of BT in 45-year-old men. Conclusions: The burden of symptoms possibly related to low T concentrations were higher in 45-year-old men, and BT and T were lower. However, due to the low answer frequency and number of blood samples analyzed no general conclusions can be drawn

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Is the Androgen Deficiency of Aging Men (ADAM) questionnaire useful for the screening of partial androgenic deficiency of aging men?

Cited by 32 publications

References 27 publications

How to recognize late-onset hypogonadism in men with sexual dysfunction

How to recognize late-onset hypogonadism in men with sexual dysfunction

A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men

Symptoms of testosterone deficiency in early middle aged men

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Is the Androgen Deficiency of Aging Men (ADAM) questionnaire useful for the screening of partial androgenic deficiency of aging men?

Cited by 32 publications

References 27 publications

How to recognize late-onset hypogonadism in men with sexual dysfunction

How to recognize late-onset hypogonadism in men with sexual dysfunction

A higher score on the Aging Males&rsquo; Symptoms scale is associated with insulin resistance in middle-aged men

Symptoms of testosterone deficiency in early middle aged men

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A higher score on the Aging Males’ Symptoms scale is associated with insulin resistance in middle-aged men