Is surgical resection useful in elderly newly diagnosed glioblastoma patients? Outcome evaluation and prognostic factors assessment

Pessina, Federico; Navarria, Pierina; Cozzi, Luca; Rudà, Roberta; Nibali, Marco Conti; Simonelli, Matteo; Costa, Francesco; Santoro, Armando; Clerici, Elena; Carta, G; Scorsetti, Marta; Bello, Lorenzo

doi:10.1007/s00701-018-3599-4

Cited by 21 publications

(23 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In controlling for surgical EOR and age, we saw that complete resection and near total resection both were associated with significantly longer survival time when compared to biopsy alone, while subtotal resection was not significantly protective. This finding is consistent with previous studies suggesting the survival benefit of complete resection 7,18 . Increasing age was associated with decreased survival, which has been repeatedly demonstrated in the literature 9,10 .…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients

Carr

Hochheimer

Rock

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Glioblastoma (GBM) is an aggressive central nervous system tumor with a poor prognosis. This study was conducted to determine any comorbid medical conditions that are associated with survival in GBM. Data were collected from medical records of all patients who presented to VCU Medical Center with GBM between January 2005 and February 2015. Patients who underwent surgery/biopsy were considered for inclusion. Cox proportional hazards regression modeling was performed to assess the relationship between survival and sex, race, and comorbid medical conditions. 163 patients met inclusion criteria. Comorbidities associated with survival on individual-characteristic analysis included: history of asthma (Hazard Ratio [HR]: 2.63; 95% Confidence Interval [CI]: 1.24–5.58; p = 0.01), hypercholesterolemia (HR: 1.95; 95% CI: 1.09–3.50; p = 0.02), and incontinence (HR: 2.29; 95% CI: 0.95–5.57; p = 0.07). History of asthma (HR: 2.22; 95% CI: 1.02–4.83; p = 0.04) and hypercholesterolemia (HR: 1.99; 95% CI: 1.11–3.56; p = 0.02) were associated with shorter survival on multivariable analysis. Surgical patients with GBM who had a prior history of asthma or hypercholesterolemia had significantly higher relative risk for mortality on individual-characteristic and multivariable analyses.

show abstract

Section: Discussionsupporting

confidence: 93%

“…To date, most studies on survival 4–11 have focused on the effects of treatment modalities 12–15 or specific patient populations such as pediatrics 16 and geriatrics 17,18 . Limited research has been conducted on demographic factors, clinical characteristics, or medical comorbidities as predictors for overall survival 10,19 .…”

Section: Introductionmentioning

confidence: 99%

Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients

Carr

Hochheimer

Rock

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…83 Patients who underwent complete resection, GTR, or STR had better outcomes in comparison with patients receiving STR or biopsy, suggesting a resection of at least 80% is required to obtain a survival benefit. 83 Furthermore, worsening or development of new postoperative neurologic deficits was found to strongly and negatively influence survival at 1 year. Similarly, a study by Babu and colleagues reviewed the effect of EOR on the prognosis of 120 patients aged !…”

Section: Extent Of Resection In the Older Populationmentioning

confidence: 95%

Importance and Evidence of Extent of Resection in Glioblastoma

Wykes

Zisakis

Irimia

et al. 2020

J Neurol Surg A Cent Eur Neurosurg

View full text Add to dashboard Cite

Maximal safe resection is an essential part of the multidisciplinary care of patients with glioblastoma. A growing body of data shows that gross total resection is an independent prognostic factor associated with improved clinical outcome. The relationship between extent of glioblastoma (GB) resection and clinical benefit depends critically on the balance between cytoreduction and avoiding neurologic morbidity. The definition of the extent of tumor resection, how this is best measured pre- and postoperatively, and its relation to volume of residual tumor is still discussed. We review the literature supporting extent of resection in GB, highlighting the importance of a standardized definition and measurement of extent of resection to allow greater collaboration in research projects and trials. Recent developments in neurosurgical techniques and technologies focused on maximizing extent of resection and safety are discussed.

show abstract

“…All these rates are much higher than the equivalent rates for adult patients. Newer data from a single-center analysis including 178 elderly patients with GBM found comparable survival rates in different stages of age and those being strongly related to preoperative KPS, eloquence of tumor origin, and extent of resection [33].…”

Section: Surgerymentioning

confidence: 97%

Guiding Treatment Choices for Elderly Patients with Glioblastoma by a Comprehensive Geriatric Assessment

et al. 2020

View full text Add to dashboard Cite

Purpose of Review The incidence of glioblastoma multiforme (GBM) increases with age; more than half of newly diagnosed patients are older than 65 years. Due to age-dependent decreasing organ functions, comorbidities, functional decline, and increasing risk of social isolation, not all patients are able to tolerate standard therapy of GBM with 6 weeks of radiochemotherapy. Recent Findings A set of alleviated therapies, e.g., chemotherapy or radiotherapy alone, hypofractionated radiotherapies with different total doses and variable fractionation regimens as well as hypofractionated radiotherapy with concomitant and adjuvant chemotherapy, have been evaluated during the last years. However, clinicians are still unsure which therapy would fit best to a given patient. Recently, the predictive value of comprehensive geriatric assessment regarding tolerance of chemotherapy and prediction of early mortality has been validated for older GBM patients in a retrospective trial. Summary Thus, it appears that neuro-oncology is now ready for the prospective implementation of geriatric assessment to guide treatment planning for elderly GBM patients.

show abstract

Is surgical resection useful in elderly newly diagnosed glioblastoma patients? Outcome evaluation and prognostic factors assessment

Abstract: Maximal surgical resection is safe and feasible in elderly patients with influence on survival. A preoperative evaluation has to be carried out.

Cited by 21 publications

References 27 publications

Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients

Comorbid Medical Conditions as Predictors of Overall Survival in Glioblastoma Patients

Importance and Evidence of Extent of Resection in Glioblastoma

Guiding Treatment Choices for Elderly Patients with Glioblastoma by a Comprehensive Geriatric Assessment

Contact Info

Product

Resources

About