Is surgery for multiple lung metastases reasonable? A total of 328 consecutive patients with multiple-laser metastasectomies with a new 1318-nm Nd:YAG laser

Rolle, Axel; Pereszlenyi, A; Koch, Rainer; Richard, Mathias L.; Baier, Barbara

doi:10.1016/j.jtcvs.2005.11.053

Cited by 124 publications

(96 citation statements)

References 15 publications

(23 reference statements)

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“…These observations indicate the existence of a rather tumour-like expression pattern in ''multiple Mets'' and are, therefore, in accordance with a worse outcome of disease of the corresponding patients, who have a decreased survival compared with patients with a limited number of Mets (up to six or nine, respectively). 7,14 Surprisingly, Gene Ontology analysis showed no over-representation of metastasis-associated processes like angiogenesis. Thus, differences in the number of Mets might result from varying growth potential rather than from different metastatic features.…”

Section: Molecular Patterns Are Associated With Varying Numbers Of Metsmentioning

confidence: 98%

“…7,8,14 In the present study, we investigated if this aggressive behaviour is reflected at the gene expression profile of these Mets. Therefore, we performed transcriptome-wide expression analyses on a homogenous cohort of pulmonary RCC Mets obtained by a new resection technique.…”

Section: Abstract: Kidney Cancer; Lung Metastases; Oligonucleotide Mmentioning

confidence: 99%

“…14 One-half of each tissue was snap-frozen in liquid nitrogen, while the other half was embedded in paraffin. Paraffinembedded tissues were histologically evaluated to ensure a complete resection in the healthy lung tissue.…”

Section: Tissue Specimensmentioning

confidence: 99%

“…7,14 As the 1,318-nm laser allowed the complete resection of all palpable lung Mets of the patients included in this study (except patient with Met 18, Table I), the number of Mets was defined as the number of all resected pulmonary Mets.…”

Section: Molecular Patterns Are Associated With Varying Numbers Of Metsmentioning

confidence: 99%

“…Therefore, we performed transcriptome-wide expression analyses on a homogenous cohort of pulmonary RCC Mets obtained by a new resection technique. 14 …”

mentioning

confidence: 99%

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Gene signatures of pulmonary metastases of renal cell carcinoma reflect the disease‐free interval and the number of metastases per patient

Wuttig

Baier²,

Fuessel

et al. 2009

Intl Journal of Cancer

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Our understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis are largely unknown. Herein, transcriptome-wide expression profiles of a unique cohort of 20 laser-resected pulmonary metastases (Mets) of 18 patients with clear-cell renal cell carcinoma (RCC) were analyzed to identify expression patterns associated with two important prognostic factors in RCC: the disease-free interval (DFI) after nephrectomy and the number of Mets per patient. Differentially expressed genes were identified by comparing early (DFI 9 months) and late (DFI 5 years) Mets, and Mets derived from patients with few ( 8) and multiple ( 16) Mets. Early and late Mets could be separated by the expression of genes involved in metastasis-associated processes, such as angiogenesis, cell migration and adhesion (e.g., PECAM1, KDR). Samples from patients with multiple Mets showed an elevated expression of genes associated with cell division and cell cycle (e.g., PBK, BIRC5, PTTG1) which indicates that a high number of Mets might result from an increased growth potential. Minimal sets of genes for the prediction of the DFI and the number of Mets per patient were identified. Microarray results were confirmed by quantitative PCR by including nine further pulmonary Mets of RCC. In summary, we showed that subgroups of Mets are distinguishable based on their expression profiles, which reflect the DFI and the number of Mets of a patient. To what extent the identified molecular factors contribute to the development of these characteristics of metastatic spread needs to be analyzed in further studies. ' UICC Key words: kidney cancer; lung metastases; oligonucleotide microarraysIn numerous tumour types, the development of metastases (Mets) causes the patients' death. The median survival of renal cell carcinoma (RCC) patients amounts to merely 6 to 12 months after Mets have been diagnosed. 1 RCC is the urological cancer with the highest percentage of tumour-related deaths 2 because metastasis occurs in about 60% of the patients. 3 The preferential localization of RCC Mets is the lung. 1 In contrast to the emerging development of molecular-based therapies for RCC in the last few years, 3 molecular prognostic markers are still missing. Despite the knowledge of several molecular factors involved in metastatic spread like angiogenesis, cell adhesion, invasion or migration, 4,5 little is known about specific characteristics of this complex process. These are, for example, primary-dependent site-specific metastasis, 6 varying dormancy periods of Mets originating from the same primary tumour entity causing disease-free intervals (DFI) ranging from several months to many years, or the differing number of Mets in patients with the same primary tumour. Knowing the molecular fundamentals of these phenomena would support the prognosis of patients' outcome and facilitate the decision for an appropriate therapy regime, particularly in RCC where the DFI and the number of Mets are important predictors of clinical...

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Section: Molecular Patterns Are Associated With Varying Numbers Of Metsmentioning

confidence: 98%

Section: Abstract: Kidney Cancer; Lung Metastases; Oligonucleotide Mmentioning

confidence: 99%

Section: Tissue Specimensmentioning

confidence: 99%

Section: Molecular Patterns Are Associated With Varying Numbers Of Metsmentioning

confidence: 99%

“…Therefore, we performed transcriptome-wide expression analyses on a homogenous cohort of pulmonary RCC Mets obtained by a new resection technique. 14 …”

mentioning

confidence: 99%

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