Is Surgery Beneficial for MEN1 Patients with Small (≤2 cm), Nonfunctioning Pancreaticoduodenal Endocrine Tumor? An Analysis of 65 Patients from the GTE

Triponez, Frédéric; Goudet, P.; Dosseh, David; Cougard, P; Bauters, C.; Murat, A.; Cadiot, Guillaume; Niccoli-Sire, Patricia; Calender, Alain; Proye, C

doi:10.1007/s00268-005-0354-9

Cited by 184 publications

(156 citation statements)

References 32 publications

(61 reference statements)

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“…For this reason, for patients with MEN1 affected by pancreatic NETs !2 cm, a careful watching policy is recommended. In these patients, it seems advisable to perform a yearly follow-up with a prompt indication for surgery when tumor diameter growth O5 mm/year (89). Surgical treatment of gastrinomas in MEN1 patients is still debated (90).…”

Section: Surgery Of Nets In Multiple Endocrine Neoplasia Type 1 Patientsmentioning

confidence: 99%

GEP–NETS UPDATE: A review on surgery of gastro-entero-pancreatic neuroendocrine tumors

Partelli

Maurizi

Tamburrino

et al. 2014

European Journal of Endocrinology

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The incidence of neuroendocrine tumors (NETs) has increased in the last decades. Surgical treatment encompasses a panel of approaches ranging from conservative procedures to extended surgical resection. Tumor size and localization usually represent the main drivers in the choice of the most appropriate surgical resection. In the presence of small (!2 cm) and asymptomatic nonfunctioning NETs, a conservative treatment is usually recommended. For localized NETs measuring above 2 cm, surgical resection represents the cornerstone in the management of these tumors. As they are relatively biologically indolent, an extended resection is often justified also in the presence of advanced NETs. Surgical options for NET liver metastases range from limited resection up to liver transplantation. Surgical choices for metastatic NETs need to consider the extent of disease, the grade of tumor, and the presence of extra-abdominal disease. Any surgical procedures should always be balanced with the benefit of survival or relieving symptoms and patients' comorbidities.

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Section: Surgery Of Nets In Multiple Endocrine Neoplasia Type 1 Patientsmentioning

confidence: 99%

GEP–NETS UPDATE: A review on surgery of gastro-entero-pancreatic neuroendocrine tumors

Partelli

Maurizi

Tamburrino

et al. 2014

European Journal of Endocrinology

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“…The peculiarity of the case besides surgical intervention was represented by pathological outcome, which identified the tumor as benign although it exceeded 2 cm. This comes in opposition with the WHO 2010 classification criteria that also claim that a neoplasm which has dimensions greater than 2 cm is considered to have a malignant development [11]. Systemic chemotherapy and radiation therapy have a limited effect on disease progression.…”

Section: Discussionmentioning

confidence: 65%

Surgical treatment of non–functioning pancreatic tumor

Puscașu¹,

Rădulescu²,

Anghel³

et al. 2015

Arch Clin Cases

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Pancreatic neuroendocrine tumors have a rare annual incidence in the general population and they are classified into functional and non-functional tumors. Non-functioning tumors represent the majority. We report an uncommon non-functional neoplasm that developed into the pancreatic isthmus. A 70-year-old woman presented at the hospital with abdominal pain, nausea and vomiting. The abdominal echography revealed a hypoechoic mass of 65/54 mm with dilatation of the upstream Wirsung duct. Non-contrast-enhanced computed tomographic demonstrated a well-enhanced mass of 4/5/6.5 cm on the head of the pancreas. An endocrine tumor of the pancreas was considered as a preoprerative diagnosis and pancreatectomy was performed with pancreatojejunum anastomosis-the Beger surgery. As a result, a non-functional endocrine tumor of the pancreas was confirmed anatomo-pathologically. The clinical manifestation of non-functioning endocrine pancreatic tumors is characterized by nonspecific symptoms. They represent a group of neoplasms which can delay the real diagnosis. Currently, CT scans are most used for detection. A rare case of non-functional neuroendocrine pancreatic neoplasm with extensive growth within the head and isthmus part of the pancreas was presented. An early detection of non-functioning endocrine neoplasm of the pancreas is very important and curative resection should be tried for a good prognosis.

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“…Several studies have suggested that larger tumors are more aggressive, and have recommended that surgery should be considered only for NFPTs larger than 2-3 cm, while smaller tumors should be carefully surveyed [10,23,24]. Recently, Triponez et al reported that surgery for NFPTs smaller than 2 cm is not beneficial for MEN1 patients, with regard to their life expectancy [25]. On the other hand, a poor correlation between tumor size and malignant behavior has also been documented [26].…”

Section: Discussionmentioning

confidence: 99%

Long-term Follow-up of Patients with Multiple Endocrine Neoplasia Type 1

et al. 2007

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Abstract. Whether early surgical treatment of non-functioning pancreas islet cell tumor (NFPT) provides a favorable quality of life and life expectancy in patients with multiple endocrine neoplasia type 1 (MEN1) remains controversial. We analyzed the long-term clinical courses and surgical outcomes of 14 Japanese patients with MEN1-associated NFPTs. NFPTs smaller than 20 mm in diameter did not show any apparent growth over a long monitoring period. Furthermore, these small NFPTs did not metastasize to regional lymph nodes or the liver. On the other hand, the development of additional NFPTs or metastasis was found in five of six patients with large (35 mm or larger) NFPTs. Among the seven patients who underwent a partial pancreatectomy, six patients developed impaired glucose tolerance or diabetes. The accumulation of more prospective data is needed to clarify the optimal surgical indications for patients with NFPTs, especially among the Japanese population, which has a relatively low insulin secretion potency compared with nonHispanic white and African-American populations.

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Is Surgery Beneficial for MEN1 Patients with Small (≤2 cm), Nonfunctioning Pancreaticoduodenal Endocrine Tumor? An Analysis of 65 Patients from the GTE

Abstract: This study suggests that surgery may not be beneficial for MEN1 patients with NFPET < or = 2 cm.

Cited by 184 publications

References 32 publications

GEP–NETS UPDATE: A review on surgery of gastro-entero-pancreatic neuroendocrine tumors

GEP–NETS UPDATE: A review on surgery of gastro-entero-pancreatic neuroendocrine tumors

Surgical treatment of non–functioning pancreatic tumor

Long-term Follow-up of Patients with Multiple Endocrine Neoplasia Type 1

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