Is Substance Abuse in Schizophrenia Related to Impulsivity, Sensation Seeking, or Anhedonia?

Dervaux, Alain; Baylé, Franck; Laqueille, Xavier; Bourdel, Marie‐Chantal; Borgne, Michèle-Hélène Le; Olié, Jean‐Pierre; Krebs, Marie‐Odile

doi:10.1176/appi.ajp.158.3.492

Cited by 124 publications

(64 citation statements)

References 11 publications

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“…These data are consistent with other studies assessing impulsivity and sensation seeking in chronic schizophrenia patients with substance abuse disorders, including alcohol, cannabis, opiate, and cocaine use [23][24][25][26][27]. Zhonitsky et al suggested that: (i) substance abuse/dependence patients with and without schizophrenia are characterized by abnormally high sensation seeking; and (ii) non-abusing schizophrenia patients are characterized by abnormally low sensation seeking [28].…”

Section: Discussionsupporting

confidence: 89%

“…Interestingly, the Zhonitsky study did not find significant differences in impulsivity between substance abuse/dependence patients with and without schizophrenia in discordance with sensation-seeking behavior. This is in discordance with our findings as well as the other studies above [23][24][25][26][27]. In line with several previous studies [23][24][25]28] and contrary to the belief that sensation seeking is a way of counteracting anhedonia in certain schizophrenia patients [29,30], we did not find a link between physical anhedonia scores and cannabis abuse in our population.…”

Section: Discussioncontrasting

confidence: 71%

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Impulsivity, Sensation Seeking and Anhedonia as Possible Explanations for Cannabis Abuse Comorbidity among First Psychotic Episode Inpatients

Katz¹,

Kunyvsky²,

Hornik-Lurie³

et al. 2017

J Addict Res Ther

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Objective: There have been relatively few reported carefully constructed studies to date concerning the link between psychoactive substance abuse among first-episode psychotic individuals and specific behavioral aspects that might clarify the comorbidity. Using standard toxicological testing, we compared consecutively admitted inpatients diagnosed with first psychotic episode with and without lifetime and/or active (last month) cannabis abuse or dependence and the levels of impulsivity, sensation seeking and anhedonia.Methods: Ninety-one consecutively admitted psychiatric patients diagnosed using the DSM-IV criteria with a first psychotic episode due to schizophrenia, schizophreniform disorder, bipolar disorder, brief psychotic episode, and psychosis NOS disorder were included in the study. Patients were aged 18 to 41 (mean 27.1+9.2); seventy-six of the patients (83.5%) were males. Standard urine tests for tetrahydrocannabinol (THC) were performed and self-report questionnaires were administered during the first 48 h after admission. The following rating scales were used: the PANSS (Positive and Negative Syndrome Scale), the Barratt Impulsivity Scale (a 34-item self-report), the Zuckerman Sensation-Seeking Scale (form V), and the Chapman Physical Anhedonia Scale (a 61-item self-report).Results: According to bivariate correlations, the PANSS Positive Scale was significantly correlated with the Barratt Rating Scale (0.260; p ≤ 0.05) and the PANSS Negative with Physical Anhedonia Scale (0.389, p ≤ 0.001). Rates for the Zuckerman Rating Scale (f=20.1, p ≤ 0.001) and the Barratt Rating Scale (f=5.15, p ≤ 0.05) were significantly higher in the group of cannabis abusers with no clear difference between abusers and nonusers in the PANSS and the Physical Anhedonia Scale. Conclusion:The results of the study showed high levels of impulsivity and sensation seeking in the group of inpatients suffering from first psychotic episode and cannabis abuse comorbidity compared to first-episode inpatients with no substance abuse.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 71%

Impulsivity, Sensation Seeking and Anhedonia as Possible Explanations for Cannabis Abuse Comorbidity among First Psychotic Episode Inpatients

Katz¹,

Kunyvsky²,

Hornik-Lurie³

et al. 2017

J Addict Res Ther

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“…In the other studies the mean age was higher [38,39] , except for the opiate addicts in the sample of Schmidt et al [16] in which a bimodal age distribution appeared, refl ecting the type of substance abused (opiates or alcohol), and the schizophrenic substance abusers in the study of Dervaux et al [46] . In all these studies the evaluation of anhedonia was performed during the early days of abstinence [16,39,46] ; only Marra et al [38] repeatedly assessed anhedonia at baseline and 2 and 6 months after withdrawal.…”

Section: Discussionmentioning

confidence: 85%

Anhedonia and Substance-Related Symptoms in Detoxified Substance-Dependent Subjects: A Correlation Study

Janiri¹,

Martinotti²,

Dario³

et al. 2005

Neuropsychobiology

132

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Anhedonia is a condition in which the capacity of experiencing pleasure is totally or partially lost, frequently occurring in mood disorders, as a negative symptom in schizophrenia, and in substance use disorders. In order to test a set of instruments for anhedonia in a population of detoxified opiate, alcohol and multiple substance-dependent subjects, 70 individuals were recruited from three different clinical settings. The following scales were applied: Snaith-Hamilton Pleasure Scale (SHAPS), Bech-Rafaelsen Melancholia Scale (BRMS), Scale for the Assessment of Negative Symptoms (SANS), specific withdrawal scales, and visual analogue scales (VAS) for hedonic capability and substance craving. The scales measuring anhedonia either directly (SHAPS, VAS for hedonic capability) or in some key items (SANS, BRMS) were significantly correlated with each other. The period of time since detoxification was inversely correlated with anhedonia and withdrawal symptomatology. Craving was positively correlated with anhedonia. Out of the total sample, only 18.5% could be defined as psychometrically anhedonic. The same correlations were found in this subsample. The composite instrument employed for assessing anhedonia and hedonic capability was found to be sensitive enough to detect such a dimension in the population considered, with the single scales significantly interrelated. In conclusion, we found interrelations between hedonic capability, craving and protracted withdrawal, particularly in opiate-dependent subjects. The strongest association occurred between hedonic capability and craving.

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“…Since INA phase magazine entry results in a mild form of punishment in terms of a temporal delay in the onset of the CS-UCS sequence, NVHL effects on increasing the proportions of INA phase approaches, while reducing proportions of CS phase approaches, may model aspects of clinical constructs of impulsivity. Numerous studies have linked behavioral trait markers of impulsivity with SUDS in primary SUD patient populations (Bickel et al 1999;McGrue et al 2001;Petry 2001), psychiatric populations with SUD comorbidity (Anthony and Helzer 1991;Dervaux et al 2001;Moeller et al 2001) and periadolescent age groups with developmental-age vulnerability to addictions (Chambers et al 2003;Ernst etal. 2003).…”

Section: Discussionmentioning

confidence: 99%

Natural reward-related learning in rats with neonatal ventral hippocampal lesions and prior cocaine exposure

et al. 2004

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Rational-Psychostimulant injections in rats have been shown to alter future performance in natural reward conditioning. These effects may represent a persistent impact of drugs on neurocircuits that interface cognitive and motivational processes, which may be further altered in neuropsychiatric conditions that entail increased addiction vulnerability.Objective-This study investigated whether a rat model of schizophrenia with cocaine addiction vulnerability shows altered natural reward conditioning with or without prior cocaine exposure.Methods-Adult rats with SHAM or neonatal ventral hippocampal lesions were given cocaine (15 mg/kg per day for 5 days) or saline injections, followed 7 days later by natural reward-conditioned learning. Over ten daily sessions, water-restricted rats were assessed for durations of head entries into a magazine during random water presentations, a conditioning stimulus phase predictive of the water reward, and an "inappropriate" phase when conditioning stimuli were absent and reward presentation would be delayed.Results-Over repeated sessions, lesioned and SHAM rats showed similar reductions in total magazine entry durations, with similar increases in the allocations of entry times during the water presentation. However, lesioned rats, especially those exposed to cocaine, demonstrated reduced allocations of magazine entry times during the conditioning stimulus phase, and increased allocations during the inappropriate phase.Conclusions-Intact natural reward motivation accompanied by deficient learning of complex contingencies to guide efficient reward approach may represent a form of impulsivity as an addiction vulnerability trait marker in an animal model of schizophrenia.

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Is Substance Abuse in Schizophrenia Related to Impulsivity, Sensation Seeking, or Anhedonia?

Abstract: As in the general population, high levels of impulsivity and sensation seeking are associated with substance abuse in patients with schizophrenia.

Cited by 124 publications

References 11 publications

Impulsivity, Sensation Seeking and Anhedonia as Possible Explanations for Cannabis Abuse Comorbidity among First Psychotic Episode Inpatients

Impulsivity, Sensation Seeking and Anhedonia as Possible Explanations for Cannabis Abuse Comorbidity among First Psychotic Episode Inpatients

Anhedonia and Substance-Related Symptoms in Detoxified Substance-Dependent Subjects: A Correlation Study

Natural reward-related learning in rats with neonatal ventral hippocampal lesions and prior cocaine exposure

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