Is SP-1 a marker for testicular cancer?

Ferritin - Another Tumor Marker for Testicular Malignancies

“…The serum values of transferrin C3 complements, hap toglobin, plasminogen and a2-macroglobin seem to be more affected by tumor metabolites or circulating im mune complexes than by tumor stage [4], Positive results in studies on the applicability of SP* and other placentaspecific tissue proteins have been reported [16], and have been confirmed by other authors [14,20], For follow-up controls of therapy, lactate dehydrogenase has also been tested and its application recommended [22], Further studies on the usefulness of carcinofetal isofer ritin, and particularly of SPb appear warranted. …”

Immunohistochemical and Radioimmunological Determination of β-HCG and Pregnancy-Specific β₁_-Protein in Seminomas

“…Rosen et al [25], however, did not find elevated SPi production on serological examination, nor did Javadpour et al [15] on immunohistochemical studies. In contrast to these re sults, Lange et al [20] found that serologically elevated SPi levels do not contradict the diagnosis of a pure se minoma, and are frequently followed by elevated HCG levels.…”

“…Several authors [1,17,20,25,26,29] have so far reported about elevated serum SPi levels in teratocarcinomas.…”

“…Syncytiotrophoblastic giant cells have been identified immunologically as production sites of this hormone [7,14], Lange el al. [20], and Rosen et al [25] recently pointed to the possible role of the pregnancy-specific Pi-protein (SP|) as a tumor marker.…”

Regulation network analysis of testicular seminoma at various stages of progression

“…The zinc finger region of SP1 transcription factors binds to GC or GT-box elements present in the promoters of a number of male germ cell target genes that are developmentally expressed during spermatogenesis (Thomas et al, 2007). Early on, SP1 was proven as a marker for testicular cancer by Lange et al (1980). JUN encodes a protein that is highly similar to the viral protein, which interacts directly with specific target DNA sequences to regulate gene expression.…”