Is South Asian ethnicity an independent cardiovascular risk factor?

Gupta, Milan; Brister, Stephanie J.; Verma, Subodh

doi:10.1016/s0828-282x(06)70895-9

Cited by 131 publications

(105 citation statements)

References 39 publications

(39 reference statements)

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“…Although Pakistan is experiencing a substantial increase in the burden of cardiovascular disease [2,3], risk factors for CHD in this population have been relatively little studied [3,5,6,20,21]. Before PROMIS, the previous largest study was INTERHEART-Pakistan, which comprised 650 MI cases and 650 controls [8].…”

Section: Discussionmentioning

confidence: 99%

“…There is limited evidence, however, about the determinants of CHD in South Asia, although such evidence should contribute importantly to scientific understanding and to the development of regionally appropriate strategies to prevent and control CHD. In particular, it has been proposed that populations in South Asia are predisposed to cardiometabolic conditions owing to a combination of hereditary and lifestyle factors that promote metabolic dysfunction [5,6], but direct evidence is sparse.…”

Section: Introductionmentioning

confidence: 99%

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The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

et al. 2009

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The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia than in any other region globally, but there is little direct evidence about its determinants. The Pakistan Risk of Myocardial Infarction Study (PROMIS) is an epidemiological resource to enable reliable study of genetic, lifestyle and other determinants of CHD in South Asia. By March 2009, PROMIS had recruited over 5,000 cases of first-ever confirmed acute myocardial infarction (MI) and over 5,000 matched controls aged 30-80 years. For each participant, information has been recorded on demographic factors, lifestyle, medical and family history, anthropometry, and a 12-lead

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

et al. 2009

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“…Although BMI as a marker of obesity was used in this study, it is established that BMI is not a good indicator of total adipose tissue concentration as well as fat distribution; the cut off for BMI [30 for obesity is controversial [28,29]. Also, Asian populations have been shown to have a greater predisposition for atherosclerosis and diabetes at a lower level of BMI [30,31]. Though some studies have used BMI [23 as cut off value, this is not yet accepted universally and a WHO expert consultation group has recommended that WHO cut offs for BMI ([30 kg/m 2 ) should be retained as such [32].…”

Section: Discussionmentioning

confidence: 99%

Study of Metabolic Syndrome and Its Risk Components in Patients Attending Tertiary Care Center of Uttarakhand

Goyal

Kumar²,

Singhai³

2013

Ind J Clin Biochem

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Metabolic syndrome is a complex of metabolic factors which includes central obesity, insulin-resistance, dyslipidemia and hypertension. Metabolic syndrome is associated with increased risk of cardiovascular disease. This study aimed to know the rate of metabolic syndrome in outpatients presenting to medicine department of our hospital and their profile. The metabolic syndrome was diagnosed using International Diabetes Federation criteria. The parameters analyzed included age, sex, blood pressure, BMI, fasting plasma glucose, HDL and triglycerides. The rate of metabolic syndrome was 21.1 % in our study. The younger population was most susceptible to metabolic derangements. Further, females were found to be affected more than males. The extremely significant parameters were deranged fasting plasma glucose, HDL, triglycerides while hypertension was found to be insignificant. Being overweight maybe a strong predictor for presence of metabolic syndrome in our region of study, and all overweight persons should be assessed and appropriately treated to prevent future cardiovascular events.

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“…This conclusion is not necessarily consistent with some studies that have reported increased arterial stiffness in the Asians compared with Caucasians. [22][23][24][25] These studies included only participants of South Asian origin, who are known to have higher rates of diabetes and premature coronary artery disease 26,27 than the South-East Asian participants in this study. Other studies are required to elucidate causes of these racial differences in BP.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure and body mass index: a comparison of the associations in the Caucasian and Asian populations

et al. 2012

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A strong association between blood pressure (BP) and body mass index (BMI) has been observed in developed and developing countries. Whether there are differences in these associations between Caucasians and Asians remains unknown. Our objective was to compare the associations of BP with fatness measures in the Caucasian and Asian samples. The study used data from two population-based cross-sectional studies conducted using similar methodology: a survey in Australia in 1998-1999 (n¼832 adults aged 25-64 years; 47% male) and a survey in Vietnam in 2005 (n¼1978 adults aged 25-64 years; 46% male). Participants completed questionnaires and attended clinics for physical measurements including BP and anthropometry. Linear regression was used for analysis. Independent of age, there were strong associations between BP indices and BMI in each sample, but the patterns of associations were different. Among Caucasians, pulse pressure (PP) increased with increasing BMI because the slope of systolic pressure with BMI exceeded the slope of diastolic pressure with BMI (Po0.001 for both sexes). In contrast, among Asians, PP decreased with increasing BMI. Associations between BMI and BP are different between Caucasian and Asian populations. Among Asians, the stronger association of increasing BMI and diastolic BP, but not PP, suggests a different pathophysiology related to hypertension.

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Is South Asian ethnicity an independent cardiovascular risk factor?

Cited by 131 publications

References 39 publications

The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

Study of Metabolic Syndrome and Its Risk Components in Patients Attending Tertiary Care Center of Uttarakhand

Blood pressure and body mass index: a comparison of the associations in the Caucasian and Asian populations

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