Is Small Artery Elasticity Decreased Prior to Intima-Media Thickening in Patients with Longstanding Rheumatoid Arthritis?

Hinkema, Helmy; Nienhuis, Hans L A; Groot, Lodewijk de; Smit, Andries J.; Roon, Arie M. van; Bijl, Marc; Posthumus, Marcel D.

doi:10.3899/jrheum.100989

Cited by 8 publications

(5 citation statements)

References 59 publications

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“…Since recognized stimuli for microvessel remodeling include hypertension and endothelial dysfunction , from our results showing that blood pressure did not differ between control rats and rats with AIA, it is tempting to conclude that endothelial dysfunction per se is not sufficient to induce microvascular remodeling during arthritis. Moreover, consistent with data obtained in RA patients , enhanced microvascular stiffness in AIA was unrelated to endothelial dysfunction but was linked to inflammation. Of note, we showed that functional microvascular abnormalities predate mechanical impairments in the course of arthritis.…”

Section: Discussionsupporting

confidence: 89%

Microvascular Abnormalities in Adjuvant‐Induced Arthritis: Relationship to Macrovascular Endothelial Function and Markers of Endothelial Activation

Totoson¹,

Maguin‐Gaté²,

Nappey³

et al. 2015

Arthritis & Rheumatology

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Objective. To determine the time course of microvascular abnormalities and the link with macrovascular endothelial function and circulating markers of endothelial activation in adjuvant-induced arthritis (AIA) in rats.Methods. Microvascular function/structure and mechanics were studied in third-order mesenteric arteries subjected to flow and/or pressure on day 4 (preclinical arthritis), day 11 (very early arthritis), day 33 (severe disease), and day 90 (when inflammation has resolved) after AIA induction. Macrovascular function was studied in aortic rings, and blood pressure, plasma levels of C-reactive protein (CRP), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) were measured at each time point.Results. Mesenteric flow-mediated vasodilation was significantly reduced from very early arthritis to chronic disease, whereas increased microvascular arterial stiffness was evident only on day 33. Macrovascular endothelial dysfunction was observed only on day 33. Thus, on day 90, whereas rats with AIA recovered normal macrovascular endothelial function, microvascular endothelial function remained impaired. No correlation was found between micro-and macrovascular endothelial function throughout the course of arthritis (r 5 0.180, P 5 0.229). Furthermore, no correlation was found between CRP levels, ICAM-1 levels, and endothelial function whatever the vascular bed. AIA was not associated with change in blood pressure or VCAM levels.Conclusion. Our findings indicate that microvascular endothelial dysfunction occurs earlier than macrovascular endothelial dysfunction and microvascular arterial stiffness during arthritis, suggesting that microvascular endothelial function would be a valuable tool for the early assessment of cardiovascular risk in RA. Neither the ICAM-1 level nor the CRP level is a good marker of micro-or macrovascular endothelial dysfunction.

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Section: Discussionsupporting

confidence: 89%

Microvascular Abnormalities in Adjuvant‐Induced Arthritis: Relationship to Macrovascular Endothelial Function and Markers of Endothelial Activation

Totoson¹,

Maguin‐Gaté²,

Nappey³

et al. 2015

Arthritis & Rheumatology

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“…From a clinical perspective, decreased endothelial function in RA led to an association between TNF, IL-1 and IL-6 with decreased FMD, similar to disease parameters, which were linked to a decrease in FMD [29]. In agreement with these findings, current evidence demonstrates an important reduction in vascular endothelium-dependent vasodilatation, which is correlated with parameters of clinical disease activity [30]. Caraba et al [31] reported similar findings, demonstrating that disease activity is positively correlated with insulin resistance and endothelial dysfunction [31].…”

Section: Rheumatoid Arthritissupporting

confidence: 82%

Traditional and Non-Traditional Risk Factors Involved with Endothelial Dysfunction and Arterial Stiffness in Autoimmune Rheumatic Diseases

Missé¹,

Borges²,

Shinjo³

2019

OJRA

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Autoimmune rheumatic diseases (ARDs) have been closely associated with accelerated plaque progression and the development of atherosclerosis, which lead to high morbidity and mortality rates for cardiovascular diseases. Endothelial dysfunction and arterial stiffness are greatly evidenced in several studies in the early phase of atherosclerosis. In ARDs, endothelial dysfunction and arterial stiffness are related to traditional and non-traditional risk factors. To date, no studies have clearly analyzed the main parameter involved in endothelial dysfunction and arterial stiffness. In this context, the present narrative review's purpose was to describe the main factor in endothelial dysfunction and arterial stiffness in different ARDs. Endothelial dysfunction and arterial stiffness are related to traditional risk factors (i.e., hypertension, diabetes, dyslipidemia, metabolic syndrome, sedentary behavior) and non-traditional risk factors (linked to the immune mechanisms involved in these diseases). Moreover, in the present study, these associations were systemically analyzed in ankylosing spondylitis, antiphospholipid syndrome, rheumatoid arthritis, psoriatic arthritis, systemic autoimmune myopathies, systemic lupus erythematosus and systemic sclerosis. The present review shows that the relationship of traditional risk factors and non-traditional risk factors related to ARDs works in the worsening of function and structural properties of arterial vessels, leading to high cardiovascular morbidity and mortality.

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“…Other recent studies of subclinical atherosclerosis in RA patients include measurements of flow mediated dilatation and small artery elasticity which continue to suggest evidence of premature atherosclerosis in patients with both early and longstanding RA (50;51). …”

Section: Measures Of Subclinical Atherosclerosis: Do They Help Us?mentioning

confidence: 99%

Cardiovascular Disease and Rheumatoid Arthritis: An Update

Charles‐Schoeman

2012

Curr Rheumatol Rep

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Patients with rheumatoid arthritis (RA) suffer significantly increased cardiovascular (CV) morbidity and mortality when compared to the general population. Both traditional CV risk factors and high levels of systemic inflammation have been linked to the increased CV risk in RA patients, but significant uncertainty remains regarding the mechanisms through which these factors contribute to CVD. In addition, ongoing questions remain regarding how best to identify RA patients at high risk for CVD, and what primary and secondary prevention strategies are effective at influencing CV outcome. The current review summarizes recent research in this field.

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Is Small Artery Elasticity Decreased Prior to Intima-Media Thickening in Patients with Longstanding Rheumatoid Arthritis?

Cited by 8 publications

References 59 publications

Microvascular Abnormalities in Adjuvant‐Induced Arthritis: Relationship to Macrovascular Endothelial Function and Markers of Endothelial Activation

Microvascular Abnormalities in Adjuvant‐Induced Arthritis: Relationship to Macrovascular Endothelial Function and Markers of Endothelial Activation

Traditional and Non-Traditional Risk Factors Involved with Endothelial Dysfunction and Arterial Stiffness in Autoimmune Rheumatic Diseases

Cardiovascular Disease and Rheumatoid Arthritis: An Update

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