Is sinus bradycardia a factor facilitating overt heart failure?

Alboni, Paoló

doi:10.1053/euhj.1998.1347

Cited by 28 publications

(21 citation statements)

References 29 publications

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“…Bradycardia, especially in older people, may facilitate heart failure through inadequate cardiac output or by inducing increased ventricular diastolic pressures. 15 Our findings support other prospective studies with community-based samples showing that binge drinking and a high heart rate are strong predictors of cardiovascular death in men. 4 , 10 …”

Section: Discussionsupporting

confidence: 90%

Modifying Effects of Resting Heart Rate on the Association of Binge Drinking With All-cause and Cardiovascular Mortality in Older Korean Men: the Kangwha Cohort Study

Ryu

Bayasgalan

Nam

et al. 2014

Journal of Epidemiology

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BackgroundAlthough binge drinking and high resting heart rate independently affect cardiovascular and all-cause mortality risk, the combined effect of these two risk factors and their interaction has rarely been studied. This study examined the association between binge drinking and cardiovascular and all-cause mortality and evaluated the potential modifying effect on this association of resting heart rate in Korean men.MethodsMen aged 55 years or older in 1985 (n = 2600) were followed for cardiovascular and all-cause mortality for 20.8 years, until 2005. We estimated hazard ratios (HRs) for cardiovascular and all-cause mortality by binge drinking and resting heart rate using the Cox proportional hazard model.ResultsHeavy binge drinkers (≥12 drinks on one occasion) with elevated resting heart rate (≥80 bpm) had a HR of 2.25 (95% confidence interval [CI], 1.47–3.45) for death from cardiovascular disease and 1.37 (95% CI, 0.87–2.14) for all-cause mortality compared to the reference group (non-drinking and resting heart rate 61–79 bpm). The HRs of dying from cardiovascular disease increased linearly from 1.36 to 1.52, 1.71, and 2.25 among individuals with resting heart rate greater than or equal to 80 bpm within the four alcohol consumption categories (non-drinking, non-binge, moderate binge, and heavy binge), respectively.ConclusionsOur findings suggest that, among older Korean men, heavy binge drinkers with an elevated resting heart rate are at high risk for cardiovascular and all-cause mortality.

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Section: Discussionsupporting

confidence: 90%

Modifying Effects of Resting Heart Rate on the Association of Binge Drinking With All-cause and Cardiovascular Mortality in Older Korean Men: the Kangwha Cohort Study

Ryu

Bayasgalan

Nam

et al. 2014

Journal of Epidemiology

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“…Below we will give a short account of some of these important mechanisms that influence the function of the channel on its way from the gene in the nucleus to the surface-expressed protein, and their significance for cardiac repolarization. FIGURE 6 gives a summarized picture of the outlined regulatory mechanisms.…”

Section: Tuning the Instrumentsmentioning

confidence: 99%

Cardiac Potassium Channel Subtypes: New Roles in Repolarization and Arrhythmia

Schmitt

Grunnet

Olesen

2014

Physiological Reviews

196

197

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About 10 distinct potassium channels in the heart are involved in shaping the action potential. Some of the K+ channels are primarily responsible for early repolarization, whereas others drive late repolarization and still others are open throughout the cardiac cycle. Three main K+ channels drive the late repolarization of the ventricle with some redundancy, and in atria this repolarization reserve is supplemented by the fairly atrial-specific KV1.5, Kir3, KCa, and K2P channels. The role of the latter two subtypes in atria is currently being clarified, and several findings indicate that they could constitute targets for new pharmacological treatment of atrial fibrillation. The interplay between the different K+ channel subtypes in both atria and ventricle is dynamic, and a significant up- and downregulation occurs in disease states such as atrial fibrillation or heart failure. The underlying posttranscriptional and posttranslational remodeling of the individual K+ channels changes their activity and significance relative to each other, and they must be viewed together to understand their role in keeping a stable heart rhythm, also under menacing conditions like attacks of reentry arrhythmia.

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“…The association of sinus bradycardia and heart failure is a complex and multifactorial problem. Sinus bradycardia was reported to worsen the outcome of patients with heart failure; however, a causative relationship was never demonstrated 2 . To the best of our knowledge, this is the first report demonstrating the causative relation between sinus bradycardia and a dilating “cardiomyopathy” causing heart failure.…”

Section: Casementioning

confidence: 79%

Bradycardiomyopathy: The Case for a Causative Relationship Between Severe Sinus Bradycardia and Heart Failure

Çalışkan

Balk

Jordaens

et al. 2010

Cardiovasc electrophysiol

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A 28-year-old man presented with progressive fatigue. Physical examination and ECG revealed severe sinus bradycardia. Echocardiography showed features of noncompaction cardiomyopathy and moderate aortic valve regurgitation. We hypothesized that the chronic volume overload exaggerated by prolonged diastole due to the bradycardia resulted in heart failure and noncompaction cardiomyopathy look-alike features. After implantation of an AAI pacemaker, his symptoms and signs of cardiomyopathy were fully recovered.

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Is sinus bradycardia a factor facilitating overt heart failure?

Cited by 28 publications

References 29 publications

Modifying Effects of Resting Heart Rate on the Association of Binge Drinking With All-cause and Cardiovascular Mortality in Older Korean Men: the Kangwha Cohort Study

Modifying Effects of Resting Heart Rate on the Association of Binge Drinking With All-cause and Cardiovascular Mortality in Older Korean Men: the Kangwha Cohort Study

Cardiac Potassium Channel Subtypes: New Roles in Repolarization and Arrhythmia

Bradycardiomyopathy: The Case for a Causative Relationship Between Severe Sinus Bradycardia and Heart Failure

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