Objective: Determine the relationship between sexual dysfunction and depression, quality of life and glycemic control. Methodology: Correlational descriptive study with the participation of 205 adults with Diabetes Mellitus Type 2. Results: 66.3% (n = 136) were females. The average age was 57 years (SD = 11.8), average number of years with Diabetes Mellitus Type 2 was 8.22 (SD = 3.9), 55.6% had good glycemic control. Regarding sexual dysfunction, 78.3% of the men and 66.9% of the women showed sexual dysfunction. 70.7% showed depression, 22% mentioned not having a good quality of life. A relationship between feminine sexual dysfunction and quality of life was identified (rs = -.241,