Is severe macrosomia manifested at 11–14 weeks of gestation?

Hackmon, Rinat; Scale, K. B. Le; Horani, Javine; Ferber, Asaf; Divon, Michael Y.

doi:10.1002/uog.5310

Cited by 27 publications

(25 citation statements)

References 34 publications

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“…This is in keeping with previous studies showing a higher risk of intrauterine growth restriction in fetuses smaller than expected in the first trimester 15,16,20 . However, to our knowledge, only one small retrospective case–control study, with 30 cases of macrosomia and 60 controls, has shown a larger than expected CRL in the first trimester; moreover, expected CRL was related to last menstrual period in most cases 28 . Our findings add to the growing body of evidence suggesting that birth size may be influenced by disturbances that occur in the first weeks of gestation.…”

Section: Discussionsupporting

confidence: 91%

Is first-trimester crown-rump length associated with birthweight?

Salomon

Hourrier

Fanchin

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

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Objective To evaluate the relationship between first-trimester crown-rump length (CRL) and birthweight (BW) Z scores.Design Retrospective cohort study.Setting Two tertiary centres in France.Population Three hundred and seventeen pregnancies conceived through assisted reproductive techniques between April 2001 and December 2008.Methods We used CRL and worked forward to BW. Only pregnancies examined during the first trimester by an Fetal Medicine Foundation-certified operator were included. CRL was expressed as Z scores, and BW was transformed into Z scores by taking gestational age and gender into account. The influence of abnormal first-trimester CRL Z scores on BW was examined.Main outcome measures Weight and gestational age at birth.Results Birth weight was significantly greater in babies with larger CRL: BW Z scores (±SD) were )0.36 (±1.05), )0.27 (±0.97), )0.10 (±1.04) and 0.13 (±0.96) in the first, second, third and fourth quartiles of CRL Z scores, respectively (P = 0.01). In contrast, there was no difference in gestational length according to the quartiles of the CRL Z scores. The CRL Z score was a significant predictor of the BW Z score (b = 0.17, P = 0.001). After adjustment for maternal body mass index, a one-point increase in the first-trimester CRL Z score (i.e. 3.6 mm) was associated with a 39% decrease, 64% increase, 114% increase and 62% increase in the risk of having a BW below the 10th centile [odds ratio (OR), 0.61; 95% confidence intervals (95% CI), 0.39; 0.95; P = 0.03], above the 90th centile (OR, 1.64; 95% CI, 1.03; 2.60; P = 0.02), above the 95th centile (OR, 2.14; 95% CI, 1.25; 3.68; P = 0.006) and above 4000 g (OR, 1.62; 95% CI, 1.04; 2.51; P = 0.04), respectively.Conclusions Variations in BW may be partly explained by differences in growth trajectories that may express as early as the first trimester.

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Section: Discussionsupporting

confidence: 91%

Is first-trimester crown-rump length associated with birthweight?

Salomon

Hourrier

Fanchin

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

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“…Several studies suggested a correlation between measurements of CRL and birth weights in both singleton and twin pregnancies, assuming that abnormal fetal growth of some fetuses can be detected early in the fi rst trimester [4,9,13] . Other studies raised the possibility of an association between NT and birth weight, based on the hypothesis that hyperglycemia may cause both measurements to be increased with the proposed mechanisms of enhancement of microvascular permeability that increases NT and elevation of fetal insulin levels that increases birth weight [3,14,15,22] .…”

Section: Introductionmentioning

confidence: 98%

Can discordance in CRL at the first trimester predict birth weight discordance in twin pregnancies?

Weissmann-Brenner¹,

Weisz²,

Achiron

et al. 2012

Journal of Perinatal Medicine

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“…Hackmon et al [13] performed a case-control study of macrosomic infants and found that their CRL measurements were more often larger than expected based on prior pregnancy dating than the normal birth weight group. Poon et al [14] approached first trimester prediction of macrosomia by comparison of maternal risk factors, nuchal translucency measurement, and the serum analytes PAPP-A and hCG between pregnancies with macrosomic infants versus those with normal weight.…”

Section: Screening For Adverse Pregnancy Outcomesmentioning

confidence: 96%

Sonographic Evaluation and the Pregnancy Complicated by Diabetes

McNamara

Odibo

2010

Curr Diab Rep

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Sonography is a fundamental tool in the management of pregnancies affected by maternal diabetes. Purposeful use of ultrasound in each trimester provides an invaluable amount of information about the developing fetus including gestational age and growth patterns, anatomical structure and function, assessment of fetal well-being, and prediction of adverse outcome. There are great ongoing research efforts in this field of prenatal diagnosis and management, yet even more are needed.

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Is severe macrosomia manifested at 11–14 weeks of gestation?

Cited by 27 publications

References 34 publications

Is first-trimester crown-rump length associated with birthweight?

Is first-trimester crown-rump length associated with birthweight?

Can discordance in CRL at the first trimester predict birth weight discordance in twin pregnancies?

Sonographic Evaluation and the Pregnancy Complicated by Diabetes

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