Is serum γ-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?

Lim, Ji Seun; Yang, Jung–Min; Chun, Bo Young; Kam, Shin; Jacobs, David R.; Lee, Dong Hoon

doi:10.1016/j.freeradbiomed.2004.06.032

Cited by 190 publications

(139 citation statements)

References 31 publications

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“…Actually, we observe a negative trend across quartiles of plasma b-carotene for most biological variables clustering in the insulin resistance syndrome, as well as for traditional and new risk factors for type II diabetes and CVD, including CRP and GGT (Best et al, 2005;Wannamethee et al, 2005). This is in agreement with recent investigations describing a negative association between serum b-carotene and GGT in young individuals, adults and alcohol drinkers with normal liver function Lim et al, 2004;Sugiura et al, 2005), and between serum b-carotene and CRP in healthy subjects (Kritchevsky et al, 2000). However, b-carotene intake in the present study shows only a marginally significant relationship with plasma b-carotene, which appears to be intimately associated with many dietary factors.…”

Section: Discussionsupporting

confidence: 92%

The total antioxidant capacity of the diet is an independent predictor of plasma β-carotene

et al. 2006

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Objective: To investigate the contribution of the total antioxidant capacity (TAC) of the diet to plasma concentrations of b-carotene. Design: Cross-sectional study. Setting: Department of Public Health and Department of Internal Medicine and Biomedical Sciences, University of Parma. Subjects: A total of 247 apparently healthy adult men (n ¼ 140) and women (n ¼ 107). Methods: A medical history, a physical exam including height, weight, waist circumference and blood pressure measurements, a fasting blood draw, an oral glucose tolerance test and a 3-day food record. Results: We observe a negative trend across quartiles of plasma b-carotene for most biological variables clustering in the insulin resistance syndrome, as well as for traditional and new risk factors for type II diabetes and cardiovascular disease (CVD), including C-reactive protein and g-glutamyltranspeptidase (Po0.05). Regarding dietary characteristics, energy-adjusted intake of fat, fiber, fruits, vegetables, b-carotene, vitamin C, vitamin E and dietary TAC significantly increased with increasing plasma b-carotene (Po0.05), whereas alcohol intake decreased (P ¼ 0.013). Adjusted geometric means (95% confidence interval) of plasma b-carotene significantly increased across quartiles of dietary TAC, even when single dietary antioxidants were considered in the model (QI ¼ 0.087 mg/dl (0.073-0.102); QII ¼ 0.087 mg/dl (0.075-0.103); QIII ¼ 0.114 mg/dl (0.098-0.132) and QIV ¼ 0.110 mg/dl (0.093-0.130); P for linear trend ¼ 0.026). When the population was divided on the basis of alcohol consumption, this trend was also observed in subjects drinking o20 g alcohol/day (P ¼ 0.034), but not in those with higher alcohol intake (P ¼ 0.448). Conclusions: Dietary TAC is an independent predictor of plasma b-carotene, especially in moderate alcohol drinkers. This may explain, at least in part, the inverse relationship observed between plasma b-carotene and risk of chronic diseases associated to high levels of oxidative stress (i.e., diabetes and CVD), as well as the failure of b-carotene supplements alone in reducing such risk. Contributors: SV participated in the study design and the collection of clinical data, performed the statistical analysis and was the primary writer of the paper, but received input from all the other authors. DDR contributed to the preparation of the paper, to laboratory analysis and to the study design. NP provided expert advice and was involved in paper editing and data interpretation. DA and LF participated in subjects' recruitment and management, in the collection and interpretation of clinical data and in the discussion of the paper. PMP and SS were involved in laboratory analysis and quality control. PR carried out the analysis of plasma b-carotene and provided expert advice on data interpretation. DDR, NP, SS and FB were responsible for the collection, completeness and interpretation of dietary data. IZ was responsible for ethical approval and subjects' recruitment. IZ and FB were responsible for the study concept and design and for sec...

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Section: Discussionsupporting

confidence: 92%

The total antioxidant capacity of the diet is an independent predictor of plasma β-carotene

et al. 2006

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“…Correlation Test on every each catagorial variable -GT with hs-CRP, Ox-LDL and GPx shows that there are escalation of -GT value, hs-CRP and Ox-LDL. This result in line with research done by Lim, et al that said there are relation between the escalation of the value of -GT serum with oxidative stress (16) (12).…”

Section: Differences Analysissupporting

confidence: 91%

“…I t also correlates positively with few cardiovascular risk factors, such as C-reactive protein (CRP) (15), fibrinogen, F2-isoprostane, and inversely related with the antioxidant quality (15,16), and consequently it would need further study to see whether -GT can be considered as a CHD risk factor, and to see the relation with the inflammation indicator, oxidative s tress and antioxidant by looking at the hs-CRP study as inflammation indicator, GPx as antioxidant indicator and Ox-LDL as indicator for oxidized LDL (16). and who showed at least one coronary stenosis of >50% of the luminar diameter were included in this study.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between gamma-Glutamyltransferase (gamma-GT) with High Sensitive C-Reactive Protein (hs-CRP), Oxidized (Ox-LDL) and Glutathione Peroxidase (GPx) on Coronary Heart Disease (CHD) Patient

Arifin¹,

Donosepoetro

Kasiman

2009

Indones Biomed J

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“…[4][5][6][7][8][9][10] GGT levels also correlate positively with novel cardiovascular risk factors, such as CRP, 38 fibrinogen, F2-isoprostanes, 39 and inversely with antioxidant levels. 40 Thus, high GGT levels are suggested as an early marker of oxidative stress and inflammation, explaining various associations in the pathway of GGT-disease-mortality. However, considering GGT as a multifunctional protein, 37 mechanisms that explain the contribution and underlying factors of GGT to CVD and mortality have not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

et al. 2009

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The aim of the present study was to investigate the association of serum gamma-glutamyltransferase (GGT) levels with all-cause mortality and to assess the impact of ultrasonographic findings of hepatic hyperechogenicity in that association. We used data from 4,160 subjects (2,044 men and 2,116 women) recruited for the population-based Study of Health in Pomerania (SHIP) without baseline hepatitis B and C infections or liver cirrhosis. GGT was divided into age-and sex-dependent quintiles to calculate overall and sex-specific crude incidence mortality rates. Hepatic steatosis was defined by elevated GGT levels (>80%) and the presence of hyperechogenic liver ultrasound. We used multiple-adjusted Cox proportional hazards regression models, first, to assess the direct effect of GGT on all-cause mortality, second, to stratify according to the ultrasonographic finding, and third, to investigate potential mediating effects of cardiometabolic risk factors. During 29,810 person-years (7.3 years, median) of follow-up, 307 individuals (7.5%) died, resulting in a death rate of 0.86 deaths per 1000 person-years. Elevated GGT levels were associated with increased risk of mortality in men (hazard ratio [HR] 1.49; 95% confidence interval [CI], 1.08-2.05), but not in women (HR 1.30; 95% CI, 0.80-2.12). This association was even stronger in men with hepatic steatosis (HR 1.98; 95% CI, 1.21-3.27). Cause-specific mortality analysis by cardiovascular disease deaths confirmed the sex-specific association. Adjustment for cardiometabolic risk factors did not affect the estimates. Conclusion: In the case of increased GGT levels, liver ultrasound should be performed, not only for diagnosis, but also for further risk stratification.

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Is serum γ-glutamyltransferase inversely associated with serum antioxidants as a marker of oxidative stress?

Cited by 190 publications

References 31 publications

The total antioxidant capacity of the diet is an independent predictor of plasma β-carotene

The total antioxidant capacity of the diet is an independent predictor of plasma β-carotene

Relationship Between gamma-Glutamyltransferase (gamma-GT) with High Sensitive C-Reactive Protein (hs-CRP), Oxidized (Ox-LDL) and Glutathione Peroxidase (GPx) on Coronary Heart Disease (CHD) Patient

Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels

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