Is serum uric acid a risk factor for coronary heart disease?

Wannamethee, S. Goya

doi:10.1038/sj.jhh.1000775

Cited by 10 publications

(4 citation statements)

References 32 publications

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“…Elevated UA commonly accompanies hypertension, hyperlipidemia, obesity, renal disease, insulin resistance, and the metabolic syndrome (Hayden & Tyagi, 2004; Weir et al, 2003). Elevated UA is associated with or increases the risk of cardiovascular disease (Sundstrom et al, 2005), and it increases the likelihood of cardiovascular events in persons with diabetes (Lehto, Niskanen, Ronnemaa, & Laakso, 1998), although its role as a causal factor is controversial (Wannamethee, 1999). Because diabetes and hypertension can lead to cognitive impairment via cerebrovascular disease (Launer, 2005; Skoog & Gustafson, 2003), elevated UA might affect cognitive functioning through cerebrovascular changes.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid and cognitive function in community-dwelling older adults.

Schretlen¹,

Inscore²,

Jinnah³

et al. 2007

Neuropsychology

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Among possible markers of age-related cognitive decline, uric acid (UA) is controversial because it has antioxidant properties but is increased in diseases that often lead to cognitive impairment. In this study of 96 elderly adults, participants with mildly elevated (but normal) serum UA were 2.7 to 5.9 times more likely to score in the lowest quartile of the sample on measures of processing speed, verbal memory, and working memory. Even after controlling for age, sex, race, education, diabetes, hypertension, smoking, and alcohol abuse, the multivariate-adjusted odds of poor verbal memory and working memory remained significant (ps < .05). Despite its antioxidant properties, these findings suggest that even mild elevations of UA might increase the risk of cognitive decline among older adults.

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Section: Discussionmentioning

confidence: 99%

Serum uric acid and cognitive function in community-dwelling older adults.

Schretlen¹,

Inscore²,

Jinnah³

et al. 2007

Neuropsychology

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“…Uric acid in interstitial fluid may protect native LDL against oxidation by transition metal ions, but it may tend to increase the oxidation of mildly oxidized LDL. The epidemiology of plasma uric acid concentrations and coronary heart disease is controversial, because plasma uric acid concentrations are related to many of the established risk factors for this disease (41). The question needs to be addressed of whether uric acid would offer antioxidant protection and protect against atherosclerosis, or would it tend to act as a prooxidant and encourage the progression of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid

Patterson

Horsley

Leake

2003

Journal of Lipid Research

131

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“…Uric acid is a metabolic by-product of purine metabolism. Both the presence and concentration of uric acid are known to contribute to the development of hypertension, and uric acid is considered a separate risk factor for hypertension [10][11][12]. Inflammation, endothelial dysfunction, the proliferation of vascular smooth muscle cells in renal microcirculation, and activation of the reninangiotensin-aldosterone system (RAAS) are some of the pathogenic activities linked to uric acid levels between 10 and 12 that cause hypertension [6].…”

Section: Introductionmentioning

confidence: 99%

A Study of Lipid Profile and the Correlation of Serum Uric Acid Levels in Patients With Hypertension

Ahlawat,

Shivnitwar,

Borle

et al. 2024

Cureus

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Aim We examine the lipid profile and correlation of serum uric acid (SUA) levels in cases of hypertension and normotensives. Methods The current observational study spanned between April 2022 and April 2024. Throughout the research, 200 patients were examined; 100 of these patients were classified as Stage 1 or Stage 2 hypertensive (as per the seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure), while the other 100 served as controls, meaning they did not have hypertension or any other medical condition that could lead to elevated SUA levels. Results It was revealed that the proportion of hypertension was higher in males compared to females. Of the total male patients, most (41.1%) patients had grade 1 hypertension and grade 2 hypertension, while among females, 20% had grade 1 hypertension. It was seen that as age increases, systolic blood pressure (SBP) and diastolic blood pressure (DBP) also rise among the two study groups, although the correlation was not statistically significant between blood pressure level and age of study subjects. The hypertensive patients have increased SBP and DBP levels when compared to the control group, which is significant. The lipid profile shows that the hypertensive subjects had significantly higher mean low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), and triglyceride levels than controls. SUA levels were observed to be elevated in the hypertensive subjects implying a positive correlation between the level of uric acid and blood pressures. Conclusion We found evidence that hyperuricemia and hypertension go hand in hand. A statistically noteworthy positive connection was found between the systolic blood pressures and lipid profiles of the patients. Hypertensive patients were found to have hyperlipidemia, whereas normotensive controls had normal lipid profiles. Moreover, it was seen that there was a positive correlation between SBP and chronological age in hypertensive cases, although this was statistically not significant.

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Is serum uric acid a risk factor for coronary heart disease?

Abstract: The role of uric acid as an independent risk factor in the development of coronary heart disease (CHD) has been questioned as serum urate is related to many of the established etiological risk factors for cardiovascular

Cited by 10 publications

References 32 publications

Serum uric acid and cognitive function in community-dwelling older adults.

Serum uric acid and cognitive function in community-dwelling older adults.

Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid

A Study of Lipid Profile and the Correlation of Serum Uric Acid Levels in Patients With Hypertension

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