Is serotonergic function associated with the antidepressant effects of modified-electroconvulsive therapy?

Goto, Shinjiro; Terao, Takeshi; Hoaki, Nobuhiko; Wang, Yumei; Tsuchiyama, Kounosuke; Araki, Yasuo; Kohno, Kentaro

doi:10.1016/j.jad.2011.11.020

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Psychological therapy is also an effective treatment for clinical depression and may prevent a person with mild depression from becoming more severely depressed, but the effect is subject to many factors. In addition to antidepressants and psychological therapy, electroconvulsive therapy (ECT) and vagus nerve stimulation (VNS) are also new solutions for depression, although more efficient, they also have significant adverse effects including retrograde amnesia [ 4 ]. All of these depression treatments are thought to be effective; however, these treatments take time, and recovery usually has its ups and downs.…”

Section: Depressionmentioning

confidence: 99%

Role and Possible Mechanisms of Sirt1 in Depression

Zhang

et al. 2018

Oxidative Medicine and Cellular Longevity

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Depression is a common, devastating illness. Due to complicated causes and limited treatments, depression is still a major problem that plagues the world. Silent information regulator 1 (Sirt1) is a deacetylase at the consumption of NAD+ and is involved in gene silencing, cell cycle, fat and glucose metabolism, cellular oxidative stress, and senescence. Sirt1 has now become a critical therapeutic target for a number of diseases. Recently, a genetic study has received considerable attention for depression and found that Sirt1 is a potential gene target. In this short review article, we attempt to present an up-to-date knowledge of depression and Sirt1 of the sirtuin family, describe the different effects of Sirt1 on depression, and further discuss possible mechanisms of Sirt1 including glial activation, neurogenesis, circadian control, and potential signaling molecules. Thus, it will open a new avenue for clinical treatment of depression.

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Section: Depressionmentioning

confidence: 99%

Role and Possible Mechanisms of Sirt1 in Depression

Zhang

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Physical therapy includes electroconvulsive therapy (ECT), vagal nerve stimulation (VNS), and transcranial magnetic stimulation (TMS). Although the safety and efficacy of physical therapy have been verified by some studies [ 33 – 35 ], the effectiveness varies from person to person [ 36 ]. Therefore, for some special types of depression, such as chronic, refractory, severe, and adolescent, the combined treatment model has become a new trend of depression treatment [ 31 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Acupuncture on Chronic Pain with Depression: A Systematic Review

Yan

Zhu

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Numerous studies suggested that chronic pain and depression were closely related and widespread in the population. When patients have symptoms of chronic pain and depression, the corresponding treatment will become difficult. Acupuncture, a unique therapeutic method of traditional Chinese medicine, has been reported to potentially serve as an alternative treatment for patients with comorbid chronic pain and depression by many research studies. Methods. A comprehensive search was conducted through the online database, including the Cochrane Library, PubMed, EMBASE, SinoMed, CNKI, and Wanfang database. Trials were RCTs published in the English or Chinese language, recruiting participants with chronic pain and depression comorbidity. The primary outcomes were the Visual Analogue Scale (VAS) and Hamilton Depression Scale (HAMD). Statistical analyses were conducted using Review Manager 5.3. Each trail was quality appraised with the five-point Jadad Score. Results. 7 eligible RCTs involving 535 patients were included. Better therapeutic effect and safety could be observed in the experimental group compared with the control group. There was a significant decrease in the VAS (mean difference (MD) = −0.68 (−1.24, −0.12), P=0.02) and HAMD (MD = −2.18 (−3.09, −1.26), P<0.00001) scores and the incidence of adverse events between two groups. Conclusion. In the treatment of chronic pain with depression, acupuncture could not only get better clinical efficacy, but also have higher security compared with medicine therapy, which can be used in patients with poorer response to the conventional medication or suffering from serious side effects.

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“…OCD is markedly different from depression in that it is insensitive to norepinephrine reuptake inhibitors ( 35 ). There may be no link between serotonergic function and ECT’s antidepressant properties ( 36 ), but it is important to ECT’s anti-obsessive-compulsive effects. The ECT, although effective in depression, seems to affect the hypothalamus, insula ( 37 ), and hippocampus ( 38 , 39 ), but in OCD, it affects the cortico-striato-thalamo-cortical circuits ( 40 – 45 ).…”

Section: Discussionmentioning

confidence: 99%

Electroconvulsive therapy for obsessive-compulsive disorder: A retrospective study

Long

Deng

et al. 2022

Front. Psychiatry

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BackgroundChronic mental diseases such as obsessive-compulsive disorder (OCD) are associated with a high disability rate. Some patients still do not improve their symptoms even with adequate cognitive-behavioral therapy and drug treatment. In the treatment of OCD, electroconvulsive therapy (ECT) is not considered a neuromodulation modality with sufficient evidence.ObjectiveThis retrospective study aimed to determine the efficacy and associated risk factors of ECT in OCD patients.Materials and methodsThe study included 21 OCD patients who underwent ECT at a high-volume center in China between January 2009 and December 2020. The demographics and clinical characteristics of the patients were assessed using descriptive statistics. Based on Clinical Global Impressions–Improvement scale, patients were categorized into response and non-response groups. Clinical and demographic characteristics of two groups of patients were compared.ResultsAn analysis of 21 patients was conducted. In total, 12 patients (57.1%) responded to ECT, 11 patients (52.4%) reported side effects, and an average of 7 ECT sessions were administered. In terms of demographic, there was no statistically significant difference between the two groups. It is noteworthy that the non-response group reported more depression and schizophrenia related disorders comorbidities than the response group (χ2 = 6.252, P = 0.041).ConclusionThe effectiveness of ECT in treating OCD is limited, especially in patients with refractory symptoms. Comorbidity with other mental disorders may affect the efficacy of ECT.

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Is serotonergic function associated with the antidepressant effects of modified-electroconvulsive therapy?

Cited by 9 publications

References 15 publications

Role and Possible Mechanisms of Sirt1 in Depression

Role and Possible Mechanisms of Sirt1 in Depression

Effect of Acupuncture on Chronic Pain with Depression: A Systematic Review

Electroconvulsive therapy for obsessive-compulsive disorder: A retrospective study

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