Is Serological Testing a Reliable Tool in Laboratory Diagnosis of Syphilis? Meta-Analysis of Eight External Quality Control Surveys Performed by the German Infection Serology Proficiency Testing Program

Müller, Iris; Brade, Volker; Hagedorn, Hans‐Jochen; Straube, E; Schörner, Christoph; Frosch, Matthias; Hlobil, Harald; Stanek, Gerold; Hunfeld, Klaus-Peter

doi:10.1128/jcm.44.4.1335-1341.2006

Cited by 53 publications

(38 citation statements)

References 11 publications

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“…In fact, the interpretation of the agglutination assay result strongly depends on the quality of the testing and the experience of the laboratory personnel. For this reason, it is often difficult to compare results from different laboratories (8).…”

Section: Discussionmentioning

confidence: 99%

Italian National Survey of Blood Donors: External Quality Assessment (EQA) of Syphilis Testing

et al. 2010

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The detection of syphilis among blood donors may reveal high-risk sexual behavior, which can go unreported at the time of donor selection and compromise the safety of the donated blood. In Italy, blood is collected, tested, and distributed by transfusion services (TSs), which also perform outpatient transfusions. We also found that the interpretation of the results of manual techniques, such as the RPR test, the VDRL test, the Treponema pallidum hemagglutination (TPHA) assay, and the T. pallidum particle agglutination (TPPA) assay, can vary greatly among different TSs and operators. Total Ig enzyme immunoassays (EIAs) are the most sensitive. However, the determination of syphilis on the basis of the results of a single test is not sufficient for an accurate screening; and all blood units should thus be assessed by two distinct treponemal tests, that is, a total Ig EIA and the TPHA or the TPPA assay.

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Section: Discussionmentioning

confidence: 99%

Italian National Survey of Blood Donors: External Quality Assessment (EQA) of Syphilis Testing

et al. 2010

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“…Studies from STD clinics and Antenatal groups have shown seroprevalence ranging from 5.4% to 8.2% and 0.84% to 0.98% respectively (Maity et al, 2011;Archana et al, 2014). Antibody detection by non treponemal/ cardiolipin and treponemal tests are the mainstay for diagnosing syphilis and for monitoring the success of subsequent antibiotic treatment (Centers for Disease Control and Prevention, 2010;Müller et al, 2014). So the main aim of the present study was to understand the occurrence of syphilis among various patient groups attending a tertiary care hospital.…”

Section: International Journal Of Current Microbiology and Applied Scmentioning

confidence: 99%

Seroprevalence of Syphilis in Patient Attending Tertiary Care Hospital, Valsad, India

Patel¹,

Patel²,

Nerurkar³

2017

Int.J.Curr.Microbiol.App.Sci

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“…The use of multiple antitreponema detection assays may be prudent for prenatal screening. 22 False-negative HIV and HTLV-1 testing have not been reported post-HSCT. 23 Infective serology screens are mandatory in both donor and recipient before HSCT, and the records should be consulted.…”

Section: Serological Testsmentioning

confidence: 99%

Challenges and pitfalls in prenatal screening in pregnancies involving allogeneic stem cell transplantation recipients

Leung

2007

Bone Marrow Transplant

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Increasing numbers of successful pregnancies are reported in recipients of allogeneic hemopoietic stem cell transplantation (HSCT). These may occur naturally, or more commonly, through assisted reproduction. The pregnancy outcomes are usually normal. There are currently no guidelines on the prenatal management of pregnancies involving HSCT recipients. HSCT recipients are unique in that their red cells, lymphocytes and even the DNA in the circulation are donor derived. As a result, typical prenatal screening tests in parents, including mean cell volume (MCV), hemoglobin pattern, blood group, infective serology and DNA screening, are all affected. The MCV cannot be used as guide for iron and folate supplements, or for thalassemia and sickle cell anemia screening. Such screening must be based on pre-HSCT indices and pre-HSCT DNA samples. The risks for hemolytic disease of newborn and hepatitis B virus transmission have to be re-evaluated, based on both preand post-HSCT patient as well as donor blood group and serology results. Good communication between obstetricians and the HSCT physician is paramount to promote successful pregnancies in this distinct patient population.

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Is Serological Testing a Reliable Tool in Laboratory Diagnosis of Syphilis? Meta-Analysis of Eight External Quality Control Surveys Performed by the German Infection Serology Proficiency Testing Program

Cited by 53 publications

References 11 publications

Italian National Survey of Blood Donors: External Quality Assessment (EQA) of Syphilis Testing

Italian National Survey of Blood Donors: External Quality Assessment (EQA) of Syphilis Testing

Seroprevalence of Syphilis in Patient Attending Tertiary Care Hospital, Valsad, India

Challenges and pitfalls in prenatal screening in pregnancies involving allogeneic stem cell transplantation recipients

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