Is semen quality related to the year of birth among Danish infertility clients?

Zheng, Yi

doi:10.1093/ije/26.6.1289

Cited by 31 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Andrology lab 2065 33.6 (5.8); 19-67 Age correlation with volume (r =̶ 0.04) Y (NS) [29] 1999 [33] 2000 Korea Andrology lab 22,249 [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] No decrease in semen volume 4 [34] 2000 Japan Andrology lab 711 >20…”

Section: Methods Of Literature Reviewmentioning

confidence: 99%

Reviewing reports of semen volume and male aging of last 33 years: From 1980 through 2013

Sengupta

2015

Asian Pacific Journal of Reproduction

View full text Add to dashboard Cite

A B S T R A C TSince several decades numerous experimental and epidemiological experiments tend to establish that in humans the semen volume declines with progression of age. This literature review is intended to report the association between male age and semen volume. Review of English language-published research over the last 33 years, from January 1, 1980, up to December 31, 2013, has been conveniently constructed using MEDLINE database. Studies with inadequate numbers of subjects and case reports were excluded. Among the methodologically stronger studies, declines in semen volume of 3%-22% were likely when comparing 30-year-old men to 50-year-old men. The report suggests that increased male age is associated with a decline in semen volume, i.e. there has been a genuine diminution in semen volume over the past 33 years. As male fertility is to some extent correlated with semen volume the results may reflect an overall reduction in male fertility.

show abstract

Section: Methods Of Literature Reviewmentioning

confidence: 99%

Reviewing reports of semen volume and male aging of last 33 years: From 1980 through 2013

Sengupta

2015

Asian Pacific Journal of Reproduction

View full text Add to dashboard Cite

show abstract

“…In humans, several retrospective studies have been performed or reviewed to determine whether sperm quality has changed over the past few decades (Carlsen et al, 1992;Auger et al, 1995;Zheng et al, 1997;Zorn et al, 1999;Jouannet et al, 2001). These studies indicate that there have been temporal and regional changes in sperm concentration.…”

Section: Introductionmentioning

confidence: 99%

Key Parameters of Sperm Motion in Relation to Male Fertility

et al. 2004

View full text Add to dashboard Cite

-This study was undertaken to detect key parameters of rat sperm motion in relation to male fertility by comparing the differences in sperm motion induced by treatment with α-chlorohydrin (ACH), known to produce spermatotoxicity, and nitrobenzene (NTB), known to produce testicular toxicity. Male rats received ACH (5 or 20 mg/kg/day) or NTB (60 mg/kg/day) for either 3 days or 18 days. Epididymal sperm was assessed for motility using a Hamilton-Thorne Sperm Analyzer (HTM-IVOS). Numerical data for statistical analysis and graphical renditions of sperm motion using parameters in radar charts and reconstructed sperm tracks were analyzed to evaluate sperm motion. Males were allowed to copulate with untreated females and cesarean sections were conducted in order to examine the effects of drug administration on male fertility. Linearity of sperm track (linearity (LIN) and/or straightness (STR)) decreased and/or beat cross frequency (BCF) increased only in ACH groups (5 or 20 mg/kg/day), although the percentage of motile sperm, sperm velocities (average path velocity (VAP), curvilinear (VCL), and straight line velocity (VSL)) and amplitude of lateral head displacement (ALH) decreased on Day 18 in both ACH and NTB (60 mg/kg/day) groups. Furthermore, from the individual reconstructed sperm tracks, it was clear that ACH-treated spermatozoa were characterized by abnormal motion ("jerking") with low vigor (low velocities) and little or no forward progression. Finally, only ACH treatment led to a reduction in pregnancy rate or infertility. Therefore, our results suggest that linearity (especially VSL, STR and LIN) in sperm motion is a key parameter for assessing a chemical's potential to induce male infertility.

show abstract

“…There is now a general consensus that human sperm quality has declined over time in different areas of the world (Auger et al 1995; Jørgensen et al 2001; Swan et al 2003), especially in younger men (López-Teijòn et al 2008; Zheng et al 1997), with indications of concurrent male sub- or infertility (Bonde et al 1998; Paasch et al 2008; Zheng et al 1997). …”

mentioning

confidence: 99%

Perinatal Exposure to Low Doses of Dioxin Can Permanently Impair Human Semen Quality

Mocarelli¹,

Gerthoux

Needham³

et al. 2011

Environ Health Perspect

167

117

View full text Add to dashboard Cite

BackgroundIn recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality.ObjectiveWe examined effects of perinatal dioxin exposure on sperm quality and reproductive hormones.MethodsWe investigated sperm quality and hormone concentrations in 39 sons (mean age, 22.5 years) born between 1977 and 1984 to mothers exposed to dioxin after the accident in Seveso, Italy (1976), and 58 comparisons (mean age, 24.6 years) born to mothers exposed only to background dioxin. Maternal dioxin levels at conception were extrapolated from the concentrations measured in 1976 serum samples.ResultsThe 21 breast-fed sons whose exposed mothers had a median serum dioxin concentration as low as 19 ppt at conception had lower sperm concentration (36.3 vs. 86.3 million/mL; p = 0.002), total count (116.9 vs. 231.1; p = 0.02), progressive motility (35.8 vs. 44.2%; p = 0.03), and total motile count (38.7 vs. 98 million; p = 0.01) than did the 36 breast-fed comparisons. The 18 formula-fed exposed and the 22 formula-fed and 36 breast-fed comparisons (maternal dioxin background 10 ppt at conception) had no sperm-related differences. Follicle-stimulating hormone was higher in the breast-fed exposed group than in the breast-fed comparisons (4.1 vs. 2.63 IU/L; p = 0.03) or the formula-fed exposed (4.1 vs. 2.6 IU/L; p = 0.04), and inhibin B was lower (breast-fed exposed group, 70.2; breast-fed comparisons, 101.8 pg/mL, p = 0.01; formula-fed exposed, 99.9 pg/mL, p = 0.02).ConclusionsIn utero and lactational exposure of children to relatively low dioxin doses can permanently reduce sperm quality.

show abstract

Is semen quality related to the year of birth among Danish infertility clients?

Abstract: We found a birth cohort effect on sperm count and morphology among Danish infertile men born after 1950 but not in men born in the first part of the century. The findings are compatible with an environmental impact during prenatal life but the evidence is far from unequivocal.

Cited by 31 publications

References 29 publications

Reviewing reports of semen volume and male aging of last 33 years: From 1980 through 2013

Reviewing reports of semen volume and male aging of last 33 years: From 1980 through 2013

Key Parameters of Sperm Motion in Relation to Male Fertility

Perinatal Exposure to Low Doses of Dioxin Can Permanently Impair Human Semen Quality

Contact Info

Product

Resources

About