Is seasonality of suicides stronger in victims with hospital-treated atopic disorders?

Timonen, Markku; Viilo, Kaisa; Hakko, Helinä; Särkioja, Terttu; Meyer-Rochow, Victor Benno; Väisänen, Erkki; Räsänen, Pirkko

doi:10.1016/j.psychres.2004.02.005

Cited by 42 publications

(40 citation statements)

References 33 publications

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“…It has been reported that allergies which involve the production of IL-4 and IL-13 are associated with increased suicide rates in women (19,23). The present findings for IL-4 in women suicide victims are consistent with these epidemiological studies.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, in a recent epidemiological survey, we reported the association of suicide completion with increased aeroallergens during high atmospheric concentration of pollen (19). In addition, other epidemiological studies have reported the association of allergies with depression (20)(21)(22), and possibly suicide (23). Therefore, the second objective was to compare the expression of the major cytokines involved in allergies, including IL-4, IL-5, and IL-13.…”

Section: Introductionmentioning

confidence: 99%

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Elevated cytokine expression in the orbitofrontal cortex of victims of suicide

Tonelli

Stiller

Rujescu

et al. 2007

Acta Psychiatr Scand

221

145

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Objective-Based on the reported association between cytokines with depression and suicide, and evidence of increased markers of inflammation in the brain of suicide victims, the present study examined the expression of cytokines in the orbitofrontal cortex of suicide victims.Method-In a postmortem sample obtained from the Brodman area 11 of suicides (n = 34) and controls (n = 17), real-time RT-PCR was used to compare the expression of mRNA species for tumor necrosis factor-a (TNF-α), interleukin (IL)-1β, 4, 5, 6, and 13.Results-Increased expression of IL-4 was found in women suicide victims and IL-13 in men suicide victims. Elevated but not significant cytokine expression was also observed for TNF-α in women suicide victims. • Limited information on psychiatric diagnoses and blood toxicology in the suicide group. Conclusion-To NIH Public Access

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Elevated cytokine expression in the orbitofrontal cortex of victims of suicide

Tonelli

Stiller

Rujescu

et al. 2007

Acta Psychiatr Scand

221

145

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“…The majority of the studies analyzed AR or AR-related proxies, one 21 and two studies also included AD. 19,20 Postolache et al 15 and Woo et al 16 both used ecological designs to test the association between suicide rates and seasonal pollen counts in the United States and Canada and in the United States. Postolache et al 15 originally found an increase in nonviolent suicide cases in young females during the peak-pollen period and older females during the postpollen period.…”

Section: Fatal Suicidal Behaviormentioning

confidence: 99%

“…The Finnish study found that individuals treated for atopic disorders died significantly more often during the first half of the year than during the second half of the year. 19 However, suicide rates in patients without allergy followed an even distribution throughout the year. The Danish study presented that 1.17% of suicides in their sample of patients treated in the hospital had a history of allergies (AR with and without bronchial asthma) compared with 0.79% of controls who did not die by suicide (incidence rate ratio 1.59 [95% CI 1.41-1.80]).…”

Section: Fatal Suicidal Behaviormentioning

confidence: 99%

Allergies and suicidal behaviors: A systematic literature review

Kõlves

Barker²,

Leo³

2015

allergy asthma proc

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“…A parallel set of discoveries stems from well-replicated findings that the incidence of suicide peaks during the spring, an initially baffling phenomenon later noted to covary with peak season for allergens (Postolache et al, 2008). Additional studies have directly linked allergic conditions to suicide completion (Qin et al, 2011; Timonen et al, 2004). Corroborative evidence is provided from an ecological study showing associations between intranasal corticosteroid anti-inflammatory therapy and lower suicide rates (Woo et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The role of cytokines in the pathophysiology of suicidal behavior

Ganança

Oquendo

Tyrka

et al. 2016

Psychoneuroendocrinology

181

128

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Objective Immune dysregulation has been implicated in depression and other psychiatric disorders. What is less clear is how immune dysregulation can affect risk of suicidal behavior. We reviewed the scientific literature concerning cytokines related to suicidal ideation, suicidal behavior and suicide, and surveyed clinical and neurobiological factors associated with cytokine levels that may modulate effects of inflammation on suicide risk. Methods We searched PubMed, Embase, Scopus and PsycINFO for relevant studies published from 1980 through February, 2015. Papers were included if they were written in English and focused on cytokine measurements in patients with suicidal behaviors. Results The literature search yielded 22 studies concerning cytokines and suicidal ideation, suicide attempts or suicide completion. The most consistent finding was elevated interleukin (IL)-6, found in 8 out of 14 studies, in CSF, blood, and postmortem brain. In one study, IL-6 in CSF was also found to be higher in violent than nonviolent attempters and to correlate with future suicide completion. Low plasma IL-2 was observed in 2 studies of suicide attempters, while divergent results were seen for tumor necrosis factor (TNF)-α, interferon (IFN)-γ, transforming growth factor (TGF)-β, IL-4, and soluble Il-2 receptors. Conclusions Given the complexity suggested by the heterogenous cytokine findings, putative mediators and moderators of inflammation on suicidal behavior merit further study. Elevated IL-6 was the most robust cytokine finding, associated with suicidal ideation and both nonfatal suicide attempts and suicides. Future studies should evaluate the predictive value of high IL-6, consider how this may alter brain function to impact suicidal behavior, and explore the potential beneficial effects of reducing IL-6 on suicide risk.

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Is seasonality of suicides stronger in victims with hospital-treated atopic disorders?

Cited by 42 publications

References 33 publications

Elevated cytokine expression in the orbitofrontal cortex of victims of suicide

Elevated cytokine expression in the orbitofrontal cortex of victims of suicide

Allergies and suicidal behaviors: A systematic literature review

The role of cytokines in the pathophysiology of suicidal behavior

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