Is sarcopenia primarily an age‐related or renin–angiotensin system‐related disorder?

Gürçay, Eda; Kara, Murat

doi:10.1111/ggi.13997

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…In light of the aforementioned data, it is paramount to consider RAS-related disorders (Table SI 1 ) ( 65 – 79 ) in the diagnosis and management of sarcopenia ( 80 ). The association between sarcopenia and hypertension also needs to be better understood ( 81 ). Among 99 variables, age, systolic arterial hypertension, mini-nutritional assessment, number of chronic diseases, and blood sodium level were found to be independent determinants of sarcopenia ( 82 ).…”

Section: Pathophysiology Of Sarcopeniamentioning

confidence: 99%

Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM

Kara¹,

Kaymak²,

Frontera³

et al. 2021

J Rehabil Med

107

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Sarcopenia is an important public health problem, characterized by age-related loss of muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and premature death. Muscle loss is mainly due to the loss of type II muscle fibres, and progressive loss of motor neurones is thought to be the primary underlying factor. Anterior thigh muscles undergo atrophy earlier, and the loss of anterior thigh muscle function may therefore be an antecedent finding. The aim of this review is to provide an in-depth (and holistic) neuromusculoskeletal approach to sarcopenia. In addition, under the umbrella of the International Society of Physical and Rehabilitation Medicine (ISPRM), a novel diagnostic algorithm is proposed, developed with the consensus of experts in the special interest group on sarcopenia (ISarcoPRM). The advantages of this algorithm over the others are: special caution concerning disorders related to the renin-angiotensin system at the case finding stage; emphasis on anterior thigh muscle mass and function loss; incorporation of ultrasound for the first time to measure the anterior thigh muscle; and addition of a chair stand test as a power/performance test to assess anterior thigh muscle function. Refining and testing the algorithm remains a priority for future research. LAY ABSTRACT Sarcopenia is an important public health problem, characterized by age-related loss of muscle mass and muscle function. The diagnostic recommendations published to date have addressed total or appendicular muscle mass. However, under the umbrella of the International Society of Physical and Rehabilitation Medicine (ISPRM), experts in the special interest group on sarcopenia (ISarcoPRM) developed a new algorithm, based on regional measurements and functional evaluations of the anterior thigh muscle, which is the most commonly and initially affected condition in sarcopenia. Unlike other suggestions, diseases associated with the renin-angiotensin system are emphasized in this algorithm, and ultrasound has been used for measurement of anterior thigh muscle mass.

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Section: Pathophysiology Of Sarcopeniamentioning

confidence: 99%

Diagnosing sarcopenia: Functional perspectives and a new algorithm from the ISarcoPRM

Kara¹,

Kaymak²,

Frontera³

et al. 2021

J Rehabil Med

107

View full text Add to dashboard Cite

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“…Drugs can also play a protective or causative role in the development of sarcopenia. Statins, sulfonylureas, glinides have a potential harmful effect on muscle metabolism; while ACE inhibitors, allopurinol, Vitamin D play a protective role on muscle function [45,46]. The muscle is formed of different types of muscle fibers: slow fibers (type I) and fast fibers (types IIa and IIb).…”

Section: Sarcopenia As Biological Substrate Of Physical Frailtymentioning

confidence: 99%

Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery

et al. 2021

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Frailty is the major expression of accelerated aging and describes a decreased resistance to stressors, and consequently an increased vulnerability to additional diseases in elderly people. The vascular aging related to frail phenotype reflects the high susceptibility for cardiovascular diseases and negative postoperative outcomes after cardiac surgery. Sarcopenia can be considered a biological substrate of physical frailty. Malnutrition and physical inactivity play a key role in the pathogenesis of sarcopenia. We searched on Medline (PubMed) and Scopus for relevant literature published over the last 10 years and analyzed the strong correlation between frailty, sarcopenia and cardiovascular diseases in elderly patient. In our opinion, a right food intake and moderate intensity resistance exercise are mandatory in order to better prepare patients undergoing cardiac operation.

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“…Although statistically insignificant (due to the small sample size), all non-survivors were overweight or obese, and the prevalence of chronic comorbidities was about two times more common in the non-survivors. As sarcopenia is primarily an age- and renin angiotensin system-related disorder (like hypertension, obesity, diabetes mellitus, and metabolic syndrome) ( 2 ); having older ages and chronic disease(s) of non-survivors might have led to sarcopenic obesity and indeed to mortality in COVID-19 ( 3 ). Yet, it is known that obesity and sarcopenia act synergistically to increase the risk of disability ( 4 ), and sarcopenic obesity was found to be an independent risk factor for mortality in the intensive care unit ( 5 ).…”

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confidence: 99%