Is salivary <scp>IgA</scp> level a potential biomarker for immunosuppression in <scp>HIV</scp>‐positive children? A systematic review and meta‐analysis

Javed, Fawad; Akram, Zohaib; Binshabaib, Munerah; ALHarthi, Shatha Subhi; Kellesarian, Sergio Varela; Vohra, Fahim

doi:10.1002/rmv.1933

Cited by 3 publications

(1 citation statement)

References 25 publications

(140 reference statements)

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“…SIgA is the main antigenic material found in saliva against oral pathogens [41]. The association between a reduction in CD4+ T-cell count and diminished SIgA is still debatable [42]. Additionally, other than candidiasis infections, the presence of caries, periodontitis, and other oral infections can also alter SIgA levels [43,44].…”

Section: Discussionmentioning

confidence: 99%

Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and Meta-Analysis

Lam

Zhou

Yiu

et al. 2022

IJERPH

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Oral health is an integral component of general health and well-being but might be undermined among children living with HIV (CLWH) due to the condition itself or the antiretroviral therapy (ART) received. This review summarises the current evidence and compares the oral health status of the CLWH who were treatment-naïve with those undergoing different ART medications. Fourteen studies were included in the final qualitative and quantitative analyses. This review identified no significant difference in the prevalence of caries, periodontal conditions, and tooth development between both groups. Orofacial opportunistic infections were more prevalent in the CLWH without ART. Children undergoing ART with a duration longer than 3 years had a significantly lower prevalence of oral candidiasis and CD4+ T-cell counts. However, due to the insufficient number of well-administered case–control studies with adequate sample size, the quality of the evidence in all outcomes was of very low certainty.

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Section: Discussionmentioning

confidence: 99%

Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and Meta-Analysis

Lam

Zhou

Yiu

et al. 2022

IJERPH

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Early-diagnosis of major depressive disorder: From biomarkers to point-of-care testing

Zhang

Diao

et al. 2023

TrAC Trends in Analytical Chemistry

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Pidotimod and Immunological Activation in Individuals Infected with HIV

Ucciferri

Falasca

Reale

et al. 2021

CHR

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Background: The improvements in HIV infection therapy and the large availability of antiretroviral drugs have led to an increased survival among HIV infected people, and a simultaneously to a raised morbidity and mortality due to notAIDS-related events in this group compared to the general population. An increased systemic inflammation and a persistent immune activation play a pivotal role in determining high rates of non-AIDS comorbidities. In the last years, many natural or synthetic immunomodulatory molecules acting by different mechanisms have been conceived. Pidotimod is a synthetic dipeptide molecule showing immunomodulatory properties. The aim of this pilot study was to evaluate the effects of Pidotimod supplementation on residual inflammation in HIV infected population. Methods: Forty HIV positive individuals under cART were enrolled: 30 were treated with Pidotimod supplementation (study group) and 10 served as control group (without Pidotimod supplementation). For all participants, Cystatin C, PCR, ESR, microalbuminuria, TNF-α, INF-γ, IL-4, IL-10, IL1β, IL-18 and IL-2 were measured at enrolment (T0), 4 weeks after of Pidotimod supplementation (T1), and 4 weeks after completing supplementation (T2). Results: In HIV positive participants treated with Pidotimod, the evaluation of cytokine levels showed that IL-10, IFN gamma, and IL-4 were significantly higher at enrolment compared to the control group. The increase under Pidotimod treatment persisted after supplementation suspension, while the pro-inflammatory cytokines levels were reduced. Salivary IgA also increased during 4 weeks of supplementation and persisted at 4 weeks after completing supplementation. On the other hand , the Cystatin C and microalbuminuria levels decreased over the time, at greater extent the Cystatin C serum levels. Conclusions: The study findings showed that the HIV population receiving Pidotimod achieved a rebalancing of proinflammatory and anti-inflammatory cytokines as well as a significant reduction in cystatin C levels. The treatment further allowed for an increase in salivary IgA levels at all the analyzed times, as secondary event to a remodulation of the immunological status obtained with pidotimod. This approach could represent a new way to design new intervention strategies aimed at improving the persistent immune activation status in the virologically suppressed HIV population.

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Is salivary IgA level a potential biomarker for immunosuppression in HIV‐positive children? A systematic review and meta‐analysis

Cited by 3 publications

References 25 publications

Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and Meta-Analysis

Impact of Antiretroviral Therapy on Oral Health among Children Living with HIV: A Systematic Review and Meta-Analysis

Early-diagnosis of major depressive disorder: From biomarkers to point-of-care testing

Pidotimod and Immunological Activation in Individuals Infected with HIV

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