Is routine calcium supplementation necessary in patients undergoing total thyroidectomy plus neck dissection?

Wu, Shengping; Gao, Li

doi:10.1007/s00595-010-4230-3

Cited by 13 publications

(9 citation statements)

References 17 publications

(17 reference statements)

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“…The following biochemical factors were not found to be associated with hypocalcaemia in any of the included studies: postoperative calcitonin, preoperative creatinine, preoperative cholesterol, preoperative albumin, preoperative thyroid hormone, preoperative phosphate and preoperative magnesium.…”

Section: Resultsmentioning

confidence: 86%

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Edafe

Antakia

Laskar

et al. 2014

British Journal of Surgery

558

491

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Section: Resultsmentioning

confidence: 86%

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Edafe

Antakia

Laskar

et al. 2014

British Journal of Surgery

558

491

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show abstract

“…In addition, the clinical value of postoperative phosphate in predicting transient hypocalcaemia is unclear, as the changes in phosphate seem to occur after the first postoperative day.…”

mentioning

confidence: 99%

Authors' reply: Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia (Br J Surg 2014; 101: 307–320)

Edafe

Antakia

Laskar

et al. 2014

British Journal of Surgery

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Authors' reply: Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia (Br J Surg 2014; 101: 307-320) SirThis is a systematic review aimed at identifying predictors of postthyroidectomy hypocalcaemia (PTH) that have been studied previously and published in the literature. The association between high postoperative phosphate and postoperative hypocalcaemia is presented in Table 1. This is not mentioned in the abstract and not detailed in the discussion as the focus was on factors identified as significant in multivariable analyses.All three papers referred to by the authors in their discussion on serum phosphate have been included in this review. We agree that phosphate is potentially a good predictor of PTH in patients without vitamin D deficiency 1 . However, no association was found between serum phosphate and PTH in patients with vitamin D deficiency 1 . Although relatively inexpensive, the use of phosphate would also require measurement of vitamin D levels.In addition, the clinical value of postoperative phosphate in predicting transient hypocalcaemia is unclear, as the changes in phosphate seem to occur after the first postoperative day 2 .In contrast to the authors' interpretation, Pattou and colleagues 3 did not find an association between early phosphate levels (within 5 days of surgery) and permanent hypocalcaemia. They did, however, find an association between delayed 'high phosphate' and permanent hypocalcaemia 3 , findings similar to those of Pisanu et al. 4 .All statements in the results and conclusion sections of the abstract are based on evidence presented in the text.

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“…Our results showed that preoperative serum magnesium levels were significantly higher in PoSH group compared to controls and postoperative serum magnesium levels were not different in the two groups. Other studies have also found no association between postoperative serum magnesium and post-thyroidectomy hypocalcaemia (25,26). In contrast, Brophy et al found similar preoperative serum magnesium levels in both groups, but lower postoperative serum magnesium levels in patients with PoSH (21).…”

Section: Discussionmentioning

confidence: 90%

Postoperative Hypoparathyroidism in Patients After Total Thyroidectomy - Experience of a Tertiary Center in Romania

Martin¹,

Parfeni²,

Mustata³

et al. 2019

chr

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şimedia declinului calciului serica fost semnificativ mai marela pacienţii cu disecţie centrală a gâtului şi limfadenectomie (1.94±0.59 vs. 1.68±0.56 mg/dl, p=0.033). Concluzii: Datele noastre indică o prevalenţă mare a PoSH, care este posibil să crească avand in vedere creşterea numărului de tiroidectomii efectuate.Cercetări suplimentare sunt necesare pentru a defini mai bine boala şi a stabili tratamentul şi măsurile preventive adecvate.

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Is routine calcium supplementation necessary in patients undergoing total thyroidectomy plus neck dissection?

Abstract: Symptomatic hypocalcemia develops within 3 days after surgery. An sCa level of less than 1.81 mmol/l can predict symptomatic hypocalcemia. Routine calcium supplements will not be necessary if the sCa level is higher than 1.81 mmol/l.

Cited by 13 publications

References 17 publications

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia

Authors' reply: Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia (Br J Surg 2014; 101: 307–320)

Postoperative Hypoparathyroidism in Patients After Total Thyroidectomy - Experience of a Tertiary Center in Romania

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