Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature

Thomson, Hannah; Labuschagne, Izelle; Greenwood, Lisa-Marie; Robinson, Emily; Sehl, Hannah; Suo, Chao; Lorenzetti, Valentina

doi:10.1007/s00213-021-05938-0

Cited by 9 publications

(10 citation statements)

References 87 publications

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“…These results are inconsistent with previous studies commonly showing seed-based RSFC differences between regions of different networks (Thomson et al, 2021). This could be attributed to the difference in methods as our study focussed on partial correlations -controlling for all other associations between networks -which might result in lower connectivity indices in general.…”

Section: Discussioncontrasting

confidence: 99%

“…These results add to a mixed evidence base in which studies with different methods have found evidence for increases as well as decreases in RSFC in the CUD compared to the control group between parietal regions and other brain regions (e.g. Thomson et al, 2021). However, within dSN network RSFC is rarely studied, and using a data-driven approach to identify RS networks (i.e.…”

Section: Discussionmentioning

confidence: 49%

“…Degenhardt et al, 2001) and experience more mental health problems (e.g. Van Ours and Williams, 2011) and these differences are common in similar studies (Thomson et al, 2021). Also, it is unclear to what extent some of the differences (e.g.…”

Section: Discussionmentioning

confidence: 98%

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Resting state functional connectivity in dependent cannabis users: the moderating role of cannabis attitudes

Kroon¹,

Toenders²,

Kuhns³

et al. 2023

Preprint

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Background. The global increase in lenient cannabis policy has been paralleled by reduced harm perception, which has been associated with cannabis use initiation and persistent use. However, it is unclear how cultural attitudes towards cannabis use might affect the brain processes underlying cannabis use. Methods. Resting state functional connectivity (RSFC) within and between the executive control network, salience network, and default mode network was assessed in 110 near-daily dependent cannabis users and 79 controls from The Netherlands and Texas, USA. Participants completed a questionnaire assessing the perceived benefits and harms of cannabis use from their personal, friends-family’s and country-state’s perspective and reported on their cannabis use (gram/week), DSM-5 cannabis use disorder (CUD) symptoms, and cannabis related problems. Results. RSFC within the dorsal salience network was lower in cannabis users than controls and was negatively associated with cannabis use in the cannabis group. Cultural attitudes – from personal, friends-family’s and country-state’s perspectives – moderated the associations of cannabis use, CUD symptoms, and cannabis use related problems with RSFC within the salience, executive control, and default mode networks. No group differences in between-network RSFC were observed, but personal perceived benefits and country-state perceived harms moderated the association between CUD symptoms and RSFC between the dorsal and ventral default mode network. Conclusions. This study highlights the importance of considering individual differences in the perceived harms and benefits of cannabis use as a factor in the associations between brain functioning and cannabis use, CUD symptoms, and cannabis use related problems.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 49%

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Resting state functional connectivity in dependent cannabis users: the moderating role of cannabis attitudes

Kroon¹,

Toenders²,

Kuhns³

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Furthermore, our study confirmed that PIU and addiction had similar neuronal activation patterns. The results of a systematic review of addiction showed that the changes of spontaneous neural activity in frontal and temporal regions were found in both substance addiction and behavior addiction ( 72 , 73 ). These abnormal functional activity changes in brain areas were mainly related to emotion and cognitive control.…”

Section: Discussionmentioning

confidence: 99%

Functional Neural Alterations in Pathological Internet Use: A Meta-Analysis of Neuroimaging Studies

et al. 2022

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Previous resting-state functional MRI (fMRI) studies found spontaneous neural activity in the brains of Pathological Internet Use (PIU) subjects. However, the findings were inconsistent in studies using different neuroimaging analyses. This meta-analytic study aimed to identify a common pattern of altered brain activity from different studies. Resting-state fMRI studies, based on whole-brain analysis methods published before July 1, 2021, were searched in multiple databases (PubMed, EMBASE, MEDLINE, and Web of Science). A voxel-based signed differential mapping (SDM) method was used to clarify brain regions, which showed anomalous activity in PIU subjects compared with healthy controls (HCs). Ten eligible publications consisting of 306 PIU subjects and 314 HCs were included in the SDM meta-analysis. Compared with HCs, subjects with PIU showed increased spontaneous neural functional activity in the left temporal pole of the superior temporal cortex, left amygdala, bilateral median cingulate cortex, and right insula. Meanwhile, a decreased spontaneous neural activity was identified in the left dorsolateral superior frontal gyrus and right middle frontal gyrus in the subjects with PIU. These abnormal brain regions are associated with cognitive executive control and emotional regulation. The consistent changes under different functional brain imaging indicators found in our study may provide important targets for the future diagnosis and intervention of PIU.Systematic Review Registration:www.crd.york.ac.uk/PROSPERO, identifier: CRD42021258119.

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“…One study on incarcerated adolescents found cannabis use to be associated with decreased low-frequency power in a number of networks including the DMN and the ECN (Thijssen et al, 2017). A recent meta-analysis of 21 cannabis user resting-state fMRI studies (Thomson et al, 2022) has identified a general pattern of increased connectivity in regular users, particularly in frontal–frontal, frontal–striatal and frontal–temporal region pairings. This analysis also found an association between effects observed in these region pairings and the various measures of cannabis exposure used in the 21 studies (e.g.…”

Section: Introductionmentioning

confidence: 99%

Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults

et al. 2023

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Background/aim: Cannabis use is highly prevalent in adolescents; however, little is known about its effects on adolescent brain function. Method: Resting-state functional magnetic resonance imaging was used in matched groups of regular cannabis users ( N = 70, 35 adolescents: 16–17 years old, 35 adults: 26–29 years old) and non-regular-using controls ( N = 70, 35 adolescents/35 adults). Pre-registered analyses examined the connectivity of seven major cortical and sub-cortical brain networks (default mode network, executive control network (ECN), salience network, hippocampal network and three striatal networks) using seed-based analysis methods with cross-sectional comparisons between user groups and age groups. Results: The regular cannabis use group (across both age groups), relative to controls, showed localised increases in connectivity only in the ECN analysis. All networks showed localised connectivity differences based on age group, with the adolescents generally showing weaker connectivity than adults, consistent with the developmental effects. Mean connectivity across entire network regions of interest (ROIs) was also significantly decreased in the ECN in adolescents. However, there were no significant interactions found between age group and user group in any of the seed-based or ROI analyses. There were also no associations found between cannabis use frequency and any of the derived connectivity measures. Conclusion: Regular cannabis use is associated with changes in connectivity of the ECN, which may reflect allostatic or compensatory changes in response to regular cannabis intoxication. However, these associations were not significantly different in adolescents compared to adults.

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Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature

Cited by 9 publications

References 87 publications

Resting state functional connectivity in dependent cannabis users: the moderating role of cannabis attitudes

Resting state functional connectivity in dependent cannabis users: the moderating role of cannabis attitudes

Functional Neural Alterations in Pathological Internet Use: A Meta-Analysis of Neuroimaging Studies

Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults

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