Is Resting Anterior EEG Alpha Asymmetry a Trait Marker for Depression?

Debener, Stefan; Beauducel, André; Nessler, Doreen; Brocke, Burkhard; Heilemann, Hubert; Kayser, Jürgen

doi:10.1159/000026630

Cited by 313 publications

(133 citation statements)

References 36 publications

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“…Henriques and Davidson [39] found that clinically depressed patients had relatively greater right-hemisphere activation than left-hemisphere activation, which was not seen in controls. The same asymmetry has been observed in multiple studies of persons with depression [40][41][42][43][44].…”

Section: Depression and Hemispheric Asymmetrysupporting

confidence: 78%

Brain Lateralization of Emotional Processing in Depression

Pereira¹,

Хан²

2017

Depression

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There are three major hypotheses regarding the lateralization of emotion in the brainthe right-hemisphere hypothesis (RHH), the valence hypothesis, and the approachwithdrawal hypothesis. The approach-withdrawal hypothesis, which is the most widely accepted, states that emotions that elicit approach behaviors are lateralized to the left hemisphere, while emotions that elicit withdrawal behaviors are lateralized to the right hemisphere. In line with this hypothesis, it has been found that persons with depression show left frontal hypoactivity and right frontal hyperactivity. This hemispheric asymmetry appears not to influence mood but rather emotional reactions to affective stimuli. That is, a person with such an asymmetry does not show a predominant negative mood, but rather heightened negative reactions to occurrences in the environment. The asymmetry may also be a biological marker of depression, with research evidence that it is found in remitted depressives and in infants of depressed mothers. Currently, research in this area focuses on identifying the mechanism underlying the link between the asymmetry and depression.

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Section: Depression and Hemispheric Asymmetrysupporting

confidence: 78%

Brain Lateralization of Emotional Processing in Depression

Pereira¹,

Хан²

2017

Depression

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“…Our results provide support for the notion that right DLPFC alterations may be involved in the generation of impairments in attentional disengagement from emotional information, a commonly observed problem in emotional disorders that is linked to sustained negative affect and emotional dysregulation (e.g., Sanchez et al, 2013). Specifically, attentional disengagement impairments observed in emotional disorders (De Raedt & Koster, 2010) may be lateralized to the right DLPFC, which would be related to hemispheric imbalances in this area, as commonly reported by previous research (e.g., Blackhart, Minnix, & Kline, 2006;Debener et al, 2000;Gotlib, 1998).…”

mentioning

confidence: 65%

Effects of tDCS over the right DLPFC on attentional disengagement from positive and negative faces: An eye-tracking study

Sánchez

Vanderhasselt

Baeken

et al. 2016

Cogn Affect Behav Neurosci

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The aim of this study was to increase insight in the neural substrates of attention processes involved in emotion regulation. The effects of right dorsolateral prefrontal cortex (i.e., DLPFC) stimulation on attentional processing of emotional information were evaluated. A novel attention task allowing a straightforward measurement of attentional engagement toward, and attentional disengagement away from emotional faces was used. A sample of healthy participants received 20 minutes of active and sham anodal transcranial direct current stimulation (i.e., tDCS) applied over the right DLPFC on 2 separate days and completed the attention task after receiving real or sham stimulation. Compared to sham stimulation, tDCS over the right DLPFC led to impairments in attentional disengagement from both positive and negative faces. Findings demonstrate a causal role of right DLPFC activity in the generation of attentional impairments that are implicated in emotional disturbances such as depression and anxiety.

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“…Beauducel et al, 2000), and further provide information about the homogeneity and trait-like stability of physiological measures (e.g. Debener et al, 2000).…”

Section: Methodsmentioning

confidence: 99%

Auditory novelty oddball allows reliable distinction of top–down and bottom–up processes of attention

Debener

Kranczioch

Herrmann

et al. 2002

International Journal of Psychophysiology

113

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An auditory novelty-oddball task, which is known to evoke a P3 event-related potential (ERP) in a target condition and a novelty-P3 ERP in response to task-irrelevant unique environmental sounds, was repeatedly applied to healthy participants (ns14) on two separate recording sessions, 7 days apart. Both target-P3 and novelty-P3 were internally consistent and test-retest reliable. Interestingly, novelty-P3 amplitude declined from the first to the second half of each recording session, whereas no systematic alteration between both sessions occurred. The target-P3 showed the opposite pattern, i.e. a reduced amplitude from the first to the second session, but no systematic change within each session. These findings suggest that novelty-P3 amplitude changes reflect habituation, whereas target-P3 session effects may indicate the adjusted amount of processing resources invested into the task. In general, the results support the interpretation of the novelty-P3 as indicating automatic, bottom-up related aspects of attention, whereas the target-P3, in the present paradigm, seems to reflect voluntary, top-down related aspects of attention. ᮊ

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Is Resting Anterior EEG Alpha Asymmetry a Trait Marker for Depression?

Cited by 313 publications

References 36 publications

Brain Lateralization of Emotional Processing in Depression

Brain Lateralization of Emotional Processing in Depression

Effects of tDCS over the right DLPFC on attentional disengagement from positive and negative faces: An eye-tracking study

Auditory novelty oddball allows reliable distinction of top–down and bottom–up processes of attention

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